DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and Fbxl17

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_056609.1	Gene:	Fbxl17 / 50758	MGIID:	1354704	Length:	701	Species:	Mus musculus

Alignment Length:	704	Identity:	143/704 - (20%)
Similarity:	235/704 - (33%)	Gaps:	196/704 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 AGATPTPAAPSGKTSVMERVTNALCGGGNSNSNSGSNSSNSNTSSASATAATSPASNANPPQTPD 113
            |.|:|.||||..:.... |....||                 ....|..|..|......||.:|.
Mouse    39 AKASPQPAAPRSRDCFF-RGPCMLC-----------------FIVHSPGAPASAGLEEEPPLSPP 85

  Fly   114 KPSRGSSPSPGGITMPGGQSQVQN------------STHHLLQQQQQQQQHMQLQQSQQQHLQLQ 166
            .|    .|..|.......|...:.            :...||..............|..:.|.|.
Mouse    86 PP----PPRDGAYAAVSSQHLARRYAALAAEDCAAAARRFLLSSAAAAAAAASSPASCCKELGLA 146

  Fly   167 ASTLINSNHHVM----VGP--------------APPTGMPLGAPPTPTVKSIAKQMNITIP---- 209
            |:.........:    |||              |||...|...|.| .::.:.|:....:|
Mouse   147 AAAAWEQQGRSLFLAGVGPVRFLGPLAAVQLFRAPPAPPPQAEPAT-ALEMVCKRKGAGVPACTP 210

  Fly   210 ----------------------GGGVN-----------------------PGSPTFSTMGMVAAQ 229
                                  |||.:                       |.||......:|||.
Mouse   211 CKQPRCGCGGCGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPPPLCPAPASPASECAPIVAAA 275

  Fly   230 KAAASAGGTPLQLRKQLP------------NPHLHHPYGSMGINAASPLIMQHQLHPPPIHSIEQ 282
            .....||||.....:|.|            ||                 ...|:..||.|..|.|
Mouse   276 GDTVRAGGTAPSSAQQQPESGDADCQEPPENP-----------------CDCHREPPPEIPDINQ 323

  Fly   283 LMLDDRFLSRFFQYFSPYERRILAQ-VCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGKL 346
              |....|.:.|...|..||.:.|. ||..||| |....::|            :|:....|.::
Mouse   324 --LPPSILLKIFSNLSLNERCLSASLVCKYWRD-LCLDFQFW------------KQLDLSSRQQV 373

  Fly   347 YNSLIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLS-------------------LRCSSI 392
            .:.|:.:       :.:..::.:::..|      ...|||                   .||..:
Mouse   374 TDELLEK-------IASRSQNIIEINIS------DCRSLSDSGVCVLAFKCPGLLRYTAYRCKQL 425

  Fly   393 SDRGLETLLDHLQSLFELELAGCNEVTEAGL--WACLTPRIVSLSLADCINIADEAVGAVAQLLP 455
            ||..:..:..|...|.::.:...:::|:.||  .......:..:....|..|:||.:..:|:...
Mouse   426 SDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSRCRELKDIHFGQCYKISDEGMIVIAKSCL 490

  Fly   456 SLYEFSLQAYH-VTDAALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSK 519
            .|....:|... |||.::..|: :....|..:....| .:|:.|::::. .|.:|:.|.|...::
Mouse   491 KLQRIYMQENKLVTDQSVKAFA-EHCPELQYVGFMGC-SVTSKGVIHLT-KLRNLSSLDLRHITE 552

  Fly   520 LTDDGVELIAENLQKLRALD--LSWCPRITDASLEYIACDLNQLEELTLDRCVHITD---IGVGY 579
            |.::.|..|.:..:.|.:|:  |:|.  |.|..:|.||.:...|:||.|..| .|||   |.:|.
Mouse   553 LDNETVMEIVKRCKNLSSLNLCLNWI--INDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGR 614

  Fly   580 ISTMLSLTALFLRWCSQVRDFGLQHLC-SMRNLQVLSLAGCPLLTSSGLSSLIQ 632
            .|  :::..:.:.||.::.|.|...:. |.::|:.|.|..|..:....:..|:|
Mouse   615 YS--VTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNELTVEQLVQ 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	8/42 (19%)
		AMN1	383..600	CDD:187754	56/243 (23%)
		leucine-rich repeat	431..456	CDD:275381	5/24 (21%)
		leucine-rich repeat	457..482	CDD:275381	6/25 (24%)
		leucine-rich repeat	483..508	CDD:275381	5/24 (21%)
		leucine-rich repeat	509..534	CDD:275381	6/24 (25%)
		leucine-rich repeat	535..560	CDD:275381	9/26 (35%)
		leucine-rich repeat	561..585	CDD:275381	11/26 (42%)
		leucine-rich repeat	586..610	CDD:275381	5/24 (21%)
		leucine-rich repeat	636..661	CDD:275381
Fbxl17	NP_056609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..93		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..250		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..321		12/58 (21%)
		F-box-like	321..368	CDD:289689	17/61 (28%)
		leucine-rich repeat	362..387	CDD:275381	4/43 (9%)
		leucine-rich repeat	388..413	CDD:275381	4/30 (13%)
		AMN1	411..573	CDD:187754	33/164 (20%)
		leucine-rich repeat	414..439	CDD:275381	5/24 (21%)
		leucine-rich repeat	440..465	CDD:275381	4/24 (17%)
		leucine-rich repeat	466..491	CDD:275381	5/24 (21%)
		leucine-rich repeat	492..517	CDD:275381	6/25 (24%)
		leucine-rich repeat	545..567	CDD:275381	5/21 (24%)
		leucine-rich repeat	568..593	CDD:275381	9/26 (35%)
		leucine-rich repeat	594..618	CDD:275381	11/26 (42%)
		leucine-rich repeat	619..644	CDD:275381	5/24 (21%)
		leucine-rich repeat	645..670	CDD:275381	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810