DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG32085 and Fbxl7

DIOPT Version :9

Sequence 1:NP_729732.1 Gene:CG32085 / 39311 FlyBaseID:FBgn0052085 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_795933.2 Gene:Fbxl7 / 448987 MGIID:3052506 Length:491 Species:Mus musculus


Alignment Length:630 Identity:137/630 - (21%)
Similarity:228/630 - (36%) Gaps:188/630 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 GGNSNSNSGSNSSNSNTSSASATAATSPASNANPPQTPDKPSRGSSPSPGGITMPGGQSQVQNST 139
            |.|:....||....|::.|:..:::|.        .||.|..|..:.|                 
Mouse     2 GANNGKQYGSEGKGSSSVSSDVSSSTD--------HTPTKAQRNVATS----------------- 41

  Fly   140 HHLLQQQQQQQQHMQLQQSQQQHLQLQASTLINSNHHVMVGPAPPTGMPLGAPPTPTVKSIAKQM 204
                                 :...|...||..        |:|    .|..||           
Mouse    42 ---------------------EDSDLSMRTLST--------PSP----ALICPP----------- 62

  Fly   205 NITIPGGGVNPGSPTFSTMGMVAAQKAAASAGGTPLQLRKQLPNPHLHHPYGSMGINAASPLIMQ 269
              |:||.....||.|           :::|..|..:.:....|...|.||...:   |:.|...|
Mouse    63 --TLPGFQNGRGSST-----------SSSSITGETVAMVHSPPPTRLTHPLIRL---ASRPQKEQ 111

  Fly   270 HQLHPPPIHSIEQLMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRE 334
            ..:...|.||:.|:          |.:....:....|:||.:|.:..: .||.|         |.
Mouse   112 ASIDRLPDHSMVQI----------FSFLPTNQLCRCARVCRRWYNLAW-DPRLW---------RT 156

  Fly   335 LRQMPGCDRGKLYNSLIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLRCSSISD--RGL 397
            :|                       |.|    :.::|..:..:.::.:      |....:  ..|
Mouse   157 IR-----------------------LTG----ETINVDRALKVLTRRL------CQDTPNVCLML 188

  Fly   398 ETLLDHLQSLFELELAGCNEVTEAGLW--ACLTPRIVSLSLADCINIADEAVGAVAQLLPSLYEF 460
            ||::          ::||..:|:.||:  |...|.:..|.::.|.||::|||..|..|.|:|...
Mouse   189 ETVI----------VSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHL 243

  Fly   461 SLQ------AYHVTDAALGYFSPKQSHSLSI--LRLQSCWELTNHGIVNIVHSLPHLTVLSLSGC 517
            .:.      ...:|..|....||.....:||  |.:..|:.|.:.|:..|......||.|.|..|
Mouse   244 DVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRC 308

  Fly   518 SKLTDDGVELIAENLQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYIST 582
            .:|||:|:..:......::.|.:|.|..::|..|..||...::|..|::..|..|||:|:.|::.
Mouse   309 VRLTDEGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAK 373

  Fly   583 MLS-LTALFLRWCSQVRDFGLQHLC-SMRNLQVLSLAGCPLLTSSGLSSL-IQLRHLQELELTNC 644
            ..| |..|..|.|..:.|.|:::|. :...|:.|.:..|||::.:||.|| :...:|:.|.|.:|
Mouse   374 YCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSC 438

  Fly   645 PG-------------------------ASHELFDYLKEHLPRCLI 664
            ..                         .|.|...::|.|..||:|
Mouse   439 ESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVI 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32085NP_729732.1 leucine-rich repeat 382..406 CDD:275381 4/25 (16%)
AMN1 383..600 CDD:187754 62/229 (27%)
leucine-rich repeat 431..456 CDD:275381 9/24 (38%)
leucine-rich repeat 457..482 CDD:275381 5/30 (17%)
leucine-rich repeat 483..508 CDD:275381 7/26 (27%)
leucine-rich repeat 509..534 CDD:275381 9/24 (38%)
leucine-rich repeat 535..560 CDD:275381 7/24 (29%)
leucine-rich repeat 561..585 CDD:275381 8/23 (35%)
leucine-rich repeat 586..610 CDD:275381 7/24 (29%)
leucine-rich repeat 636..661 CDD:275381 8/49 (16%)
Fbxl7NP_795933.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79 26/158 (16%)
F-box-like 114..160 CDD:289689 14/88 (16%)
leucine-rich repeat 129..151 CDD:275381 4/22 (18%)
leucine-rich repeat 154..187 CDD:275381 7/74 (9%)
AMN1 <185..366 CDD:187754 53/190 (28%)
LRR 1 185..210 9/34 (26%)
leucine-rich repeat 188..213 CDD:275381 9/34 (26%)
LRR 2 211..236 9/24 (38%)
leucine-rich repeat 214..234 CDD:275381 7/19 (37%)
LRR 3 237..262 4/24 (17%)
leucine-rich repeat 240..273 CDD:275381 5/32 (16%)
LRR 4 271..296 7/24 (29%)
leucine-rich repeat 274..299 CDD:275381 6/24 (25%)
AMN1 297..464 CDD:187754 45/166 (27%)
LRR 5 297..322 9/24 (38%)
leucine-rich repeat 300..325 CDD:275381 9/24 (38%)
LRR 6 323..348 7/24 (29%)
leucine-rich repeat 326..351 CDD:275381 7/24 (29%)
LRR 7 349..374 8/24 (33%)
leucine-rich repeat 352..377 CDD:275381 8/24 (33%)
LRR 8 375..400 8/24 (33%)
leucine-rich repeat 378..403 CDD:275381 7/24 (29%)
LRR 9 401..426 9/24 (38%)
leucine-rich repeat 404..429 CDD:275381 9/24 (38%)
LRR 10 427..452 4/24 (17%)
leucine-rich repeat 430..453 CDD:275381 4/22 (18%)
leucine-rich repeat 456..480 CDD:275381 4/23 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.