DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32085 and CG9003

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	170/757 - (22%)
Similarity:	268/757 - (35%)	Gaps:	237/757 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSISAQGVVERASAELSKRINGLGLRSKHHHSSTSSGAGGAGDAASPAGATPTPAAPSGKTSVME 66
            :|.:..||:|......:    |.|..|.::...:||.:||||      |:......|||.:|:
  Fly     3 ASSAETGVMEVGGTSGT----GTGSSSSNNGGGSSSNSGGAG------GSIELLCPPSGSSSI-- 55

  Fly    67 RVTNALCGGGNSNSNSGSNSSNSNTSSASATAATSPASNANPPQTPDKPSRGSSPSPGGITMPGG 131
                  .|..:.:||||::.|:|.|.|.:.::||..::|......|.....|:          ||
  Fly    56 ------SGSASFSSNSGASGSSSQTHSTAVSSATDRSNNNGNNHNPSLQLNGN----------GG 104

  Fly   132 QSQVQ-----NSTHHLLQQQQQQQQHMQLQQSQQQHLQLQASTLINSNHHVMV------------ 179
            .:..|     ||..|..........::....|....   ..|...|:||...:
  Fly   105 SNTRQHSSGSNSRQHSSSSSNSNSSNISPPPSSSSS---SRSNNNNNNHSSNIISGFCSTIWRSA 166

  Fly   180 --GPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNP------------GSPTFSTMGMVAAQK 230
              |.|.|...||                   |...:||            .|.|...:|:...|:
  Fly   167 TFGSATPVINPL-------------------PAVSINPKIMESSSDSCSLSSSTTPDVGLADQQR 212

  Fly   231 AAASA-------------GGTPL--QLRKQLPNPHLHHPYGSMGINAASPLIMQHQLHPPPIHSI 280
            ..|.:             |.|.|  :|.||||.
  Fly   213 NMAGSAQDQSEDQSQTFLGATELDDELIKQLPK-------------------------------- 245

  Fly   281 EQLMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLL---PTLQCRELRQMPGCD 342
                   ..|.|.|.|.........||||           :||:.|.   .:.|...|.......
  Fly   246 -------EVLLRVFSYLDVVSLCRCAQVC-----------KYWNVLALDGSSWQKINLFDFQRDI 292

  Fly   343 RGKLYNSLIR--RGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLR-CSSISDRGLETLLDHL 404
            .|.:..::.:  |||                          :.||||| |.|:.|:.:.||.:|.
  Fly   293 EGPVIENISQRCRGF--------------------------LKSLSLRGCQSVGDQSVRTLANHC 331

  Fly   405 QSLFELELAGCNEVTEAGLWA----CLTPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAY 465
            .::..|:|:.|.::|:....:    |  .::.:::|..|.||.|.::..::...|:|.|.::...
  Fly   332 HNIEHLDLSDCKKITDISTQSISRYC--SKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWC 394

  Fly   466 HVTD-----------AALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSK 519
            |:..           ..|..||.|           .|.::.::.|:.:....|.|.||:|..|..
  Fly   395 HLISENGVEALARGCVKLRKFSSK-----------GCKQINDNAIMCLAKYCPDLMVLNLHSCET 448

  Fly   520 LTDDGVELIAENLQKLRALDLSWCPRITDA-------------SLEYIAC-------------DL 558
            :||..:..:|.|..||:.|.:|.|..:||.             :||...|             :.
  Fly   449 ITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNC 513

  Fly   559 NQLEELTLDRCVHITDIGVGYIST-MLSLTALFLRWCSQVRDFGLQHL----CSMRNLQVLSLAG 618
            ..||.:.|:.|..|||:.:.:::| ..||..|.|..|..:.|.|::||    |:...|.||.|..
  Fly   514 KYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHLTTGSCAAEILSVLELDN 578

  Fly   619 CPLLTSSGLSSLIQLRHLQELELTNCPGASHELFDYLKEHLP 660
            |||:|...|..|:...:||.:||.:|...:......||.|||
  Fly   579 CPLITDRTLEHLVSCHNLQRIELFDCQLITRTAIRKLKNHLP 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	11/24 (46%)
		AMN1	383..600	CDD:187754	64/259 (25%)
		leucine-rich repeat	431..456	CDD:275381	5/24 (21%)
		leucine-rich repeat	457..482	CDD:275381	7/35 (20%)
		leucine-rich repeat	483..508	CDD:275381	2/24 (8%)
		leucine-rich repeat	509..534	CDD:275381	9/24 (38%)
		leucine-rich repeat	535..560	CDD:275381	9/50 (18%)
		leucine-rich repeat	561..585	CDD:275381	8/24 (33%)
		leucine-rich repeat	586..610	CDD:275381	9/27 (33%)
		leucine-rich repeat	636..661	CDD:275381	10/25 (40%)
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	16/94 (17%)
		leucine-rich repeat	280..307	CDD:275381	4/26 (15%)
		AMN1	<308..453	CDD:187754	39/157 (25%)
		leucine-rich repeat	308..327	CDD:275381	8/18 (44%)
		leucine-rich repeat	334..359	CDD:275381	5/26 (19%)
		leucine-rich repeat	360..385	CDD:275381	5/24 (21%)
		leucine-rich repeat	386..411	CDD:275381	3/24 (13%)
		AMN1	<409..586	CDD:187754	52/187 (28%)
		leucine-rich repeat	412..437	CDD:275381	6/35 (17%)
		leucine-rich repeat	438..463	CDD:275381	9/24 (38%)
		leucine-rich repeat	464..515	CDD:275381	9/50 (18%)
		leucine-rich repeat	516..541	CDD:275381	8/24 (33%)
		leucine-rich repeat	542..561	CDD:275381	6/18 (33%)
		leucine-rich repeat	571..595	CDD:275381	10/23 (43%)
		leucine-rich repeat	596..621	CDD:275381	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I1756
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47209
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.890