DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and fbxl5

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001288257.1	Gene:	fbxl5 / 322181	ZFINID:	ZDB-GENE-030131-900	Length:	679	Species:	Danio rerio

Alignment Length:	504	Identity:	103/504 - (20%)
Similarity:	156/504 - (30%)	Gaps:	197/504 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 LDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCR---------------- 333
            |....|.|.|::..|.:....||||..|.. :.|:...|..|.|....|
Zfish   211 LPQELLLRIFRFLGPQDLCRCAQVCSVWTQ-VTRTGSLWRHLYPVRWARGEYYSGPPGDLDLEPD 274

  Fly   334 -------------------------------ELRQMPGCDRGK-LYNSLIRRGFHALGLVGASDE 366
                                           |...:....|.| |.|.:|::...|:|    |..
Zfish   275 DDWIKSLQDDGRAYQEWDEDADVDESEEASAERSSISALQREKLLLNGIIQKLLPAVG----SSV 335

  Fly   367 DALDVVHSFPLASKHVHSLSLRCSSISDRGLETLLDHLQSLFE-------------LELAGCNEV 418
            .:|.:.:|..|:||.|..:...|.:::...| |..|...|.|:             |:|:||:::
Zfish   336 RSLSLAYSSTLSSKMVRQMLSLCPNLTHLDL-TQTDVSDSAFDSWCALGACGTLQHLDLSGCDKI 399

  Fly   419 TEAGLWACLTPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQSHSL 483
            |:.      |.:|:|:.|.|             ...||.....|||            |.....:
Zfish   400 TDR------TLKILSVGLGD-------------SSTPSPAHKLLQA------------PPSPIRI 433

  Fly   484 SILRLQ----SCWELT------NHGIVNIVHSLPHLTVLSLSGCS----------KLTDDGVELI 528
            ...|||    ||.:|.      ..|                |||.          ||.|  :|..
Zfish   434 EEPRLQPMGRSCQDLIFKRRPGGRG----------------SGCGPTHIWVLDPVKLAD--IEDA 480

  Fly   529 AENLQK-------------LRALDLSWCPRIT-----------------DASLEYIACDLNQLEE 563
            |:..::             ..||..|.|.|.:                 ||...:.:|..:....
Zfish   481 ADWSRRGGVASQEIGCGGISEALSASCCCRRSQRRGFRTGLSSSPWQYGDALCGHSSCCSSDAAA 545

  Fly   564 LTLDRCVHITDIGVGYIST---------------------MLSLTALFLRWCSQVRDFGLQHLC- 606
            |.....:..|. |...:.|                     ..:|..|.|..|.|:.|.||:.:|
Zfish   546 LRTQSDLQATG-GSAELRTKCWFEGQSCAEHHNRTDQSGAQRALRFLSLSGCHQITDLGLRCVCL 609

  Fly   607 --SMRNLQVLSLAGCPLLTSSGL------SSLIQLRHLQELELTNCPGA 647
              .:..|:.|:|:||||:|.:||      |..:.:.|....:..|.|.|
Zfish   610 RGGLPLLEHLNLSGCPLITGAGLQEVVSASPALNIEHFYYCDNINGPHA 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	5/23 (22%)
		AMN1	383..600	CDD:187754	54/300 (18%)
		leucine-rich repeat	431..456	CDD:275381	4/24 (17%)
		leucine-rich repeat	457..482	CDD:275381	4/24 (17%)
		leucine-rich repeat	483..508	CDD:275381	7/34 (21%)
		leucine-rich repeat	509..534	CDD:275381	8/34 (24%)
		leucine-rich repeat	535..560	CDD:275381	8/41 (20%)
		leucine-rich repeat	561..585	CDD:275381	4/44 (9%)
		leucine-rich repeat	586..610	CDD:275381	9/26 (35%)
		leucine-rich repeat	636..661	CDD:275381	3/12 (25%)
fbxl5	NP_001288257.1	Hemerythrin-like. /evidence=ECO:0000250	1..159
		Hr_FBXL5	7..155	CDD:213984
		F-box-like	208..252	CDD:289689	12/41 (29%)
		AMN1	313..>410	CDD:187754	28/107 (26%)
		LRR 1	316..342		8/29 (28%)
		leucine-rich repeat	335..360	CDD:275381	7/24 (29%)
		LRR 2	343..367		7/24 (29%)
		leucine-rich repeat	361..387	CDD:275381	5/26 (19%)
		LRR 3	368..395		5/26 (19%)
		leucine-rich repeat	388..422	CDD:275381	12/52 (23%)
		LRR 4	396..426		10/48 (21%)
		leucine-rich repeat	423..447	CDD:275381	9/35 (26%)
		leucine-rich repeat	510..574	CDD:275381	8/64 (13%)
		LRR 5	565..595		3/29 (10%)
		AMN1	566..>644	CDD:187754	20/77 (26%)
		leucine-rich repeat	588..615	CDD:275381	9/26 (35%)
		LRR 6	596..623		9/26 (35%)
		leucine-rich repeat	616..641	CDD:275381	11/24 (46%)
		LRR 7	624..649		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010