DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_011248071.1	Gene:	Fbxl13 / 320118	MGIID:	2443416	Length:	889	Species:	Mus musculus

Alignment Length:	446	Identity:	103/446 - (23%)
Similarity:	193/446 - (43%)	Gaps:	84/446 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 LIMQHQLH--------PPPIH---SIEQLMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTL--Y 317
            ||.:|:|.        ..||.   |:..:.:::|.:: |.....|.:..:...:.:.::|.:  .
Mouse   201 LISKHELQLKKWKFKLGKPISLEGSLSDIAVENRRIA-FDISVLPEQAILQIFLYLTFKDMMACS 264

  Fly   318 RSPRYWSGLLPTLQCRELRQMPGCDRGKLYNSLIRRGFHALGLVGASDEDALDVVHSFPLASKHV 382
            |..|.|..::              .||.|:||:   .|..:..:  :|:..:..:..:.|   :|
Mouse   265 RVNRSWMAMI--------------QRGSLWNSI---DFSTVKNI--ADKCVVTTLQKWRL---NV 307

  Fly   383 HSLSLRCSSISDRGLETLLDHLQSLFELELAGCNEVTEAGL----WACLTPRIVSLSLADCINIA 443
            ..|:.|......:.|:. :.|.::|.||.::.|...|:..:    ..|  |.::.|:|:: ..|.
Mouse   308 LRLNFRGCDFRTKTLKA-VSHCKNLQELNVSDCQSFTDESMRHISEGC--PGVLYLNLSN-TTIT 368

  Fly   444 DEAVGAVAQLLPSLYEFSLQAY--HVTDAALGYFS-PKQSHSLSILRLQSCWELTNHGIVNIVHS 505
            :..:..:.:...:|...|| ||  ..||..|.|.: ....|.|..|.|..|.:::..|..||..|
Mouse   369 NRTMRLLPRYFHNLQNLSL-AYCRKFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRNIASS 432

  Fly   506 LPHLTVLSLSGCSKLTDDGVELIAENLQKLRALDLSWCPRITDASLEYI-ACDLNQLE------- 562
            ...:..|:::....|||:.|:::.|...::.::.|...|.|:|::.:.: :|||.::.
Mouse   433 CTGIVHLTINDMPTLTDNCVKVLVEKCPRISSVVLIGSPHISDSAFKALSSCDLKKIRFEGNKRI 497

  Fly   563 ----ELTLDR------------CVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHL----CS 607
                ..::||            |..:||..:..:|.:..||.|.|..|.::.|.||:|.    .|
Mouse   498 SDACFKSIDRNYPGINHIYMVDCKGLTDSSLKSLSLLKQLTVLNLTNCIRIGDIGLKHFFDGPAS 562

  Fly   608 MRNLQVLSLAGCPLLTSSGLSSLIQLR----HLQELELTNCPGASHELFDYLKEHL 659
            :| |:.|:|..|.||   |.||:|:|.    :|..|.|.||...:....:|:...|
Mouse   563 IR-LRELNLTNCSLL---GDSSVIRLSERCPNLHYLNLRNCEHLTDLAIEYIASML 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	5/23 (22%)
		AMN1	383..600	CDD:187754	56/247 (23%)
		leucine-rich repeat	431..456	CDD:275381	3/24 (13%)
		leucine-rich repeat	457..482	CDD:275381	9/27 (33%)
		leucine-rich repeat	483..508	CDD:275381	8/24 (33%)
		leucine-rich repeat	509..534	CDD:275381	6/24 (25%)
		leucine-rich repeat	535..560	CDD:275381	7/25 (28%)
		leucine-rich repeat	561..585	CDD:275381	6/46 (13%)
		leucine-rich repeat	586..610	CDD:275381	10/27 (37%)
		leucine-rich repeat	636..661	CDD:275381	7/24 (29%)
Fbxl13	XP_011248071.1	F-box-like	240..284	CDD:372399	10/60 (17%)
		leucine-rich repeat	255..268	CDD:275381	2/12 (17%)
		leucine-rich repeat	280..306	CDD:275381	5/33 (15%)
		AMN1	306..475	CDD:187754	42/173 (24%)
		leucine-rich repeat	307..330	CDD:275381	5/23 (22%)
		leucine-rich repeat	331..356	CDD:275381	6/26 (23%)
		leucine-rich repeat	357..381	CDD:275381	3/24 (13%)
		leucine-rich repeat	382..409	CDD:275381	9/27 (33%)
		leucine-rich repeat	410..435	CDD:275381	8/24 (33%)
		leucine-rich repeat	436..461	CDD:275381	6/24 (25%)
		leucine-rich repeat	462..484	CDD:275381	4/21 (19%)
		AMN1	473..605	CDD:187754	38/135 (28%)
		leucine-rich repeat	486..511	CDD:275381	3/24 (13%)
		leucine-rich repeat	512..536	CDD:275381	4/23 (17%)
		leucine-rich repeat	537..564	CDD:275381	10/26 (38%)
		leucine-rich repeat	565..590	CDD:275381	11/27 (41%)
		leucine-rich repeat	591..610	CDD:275381	5/18 (28%)
		leucine-rich repeat	617..645	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810