DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and Fbxl17

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_038939705.1	Gene:	Fbxl17 / 316663	RGDID:	1309773	Length:	739	Species:	Rattus norvegicus

Alignment Length:	751	Identity:	140/751 - (18%)
Similarity:	236/751 - (31%)	Gaps:	288/751 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SPAGATPTPAAPSGKTSVMERVTNALCGGGNSNSNSGSNSSNSNTSSASATAATSPAS-NANPPQ 110
            :||.|:|.||||..:.... |....||                  ....:..|.:||. ...||.
  Rat    37 TPAKASPQPAAPRSRDCFF-RGPCMLC------------------FIVHSPGAPAPAGLEEEPPL 82

  Fly   111 TPDKPSRGSSPSPGGITMPGGQSQVQNSTHHLLQQQQQQQQHMQLQQSQQQHLQLQASTLINSN- 174
            :|  |.|           .|..:.|  |:.||.::............:::..|...|:...:|:
  Rat    83 SP--PPR-----------DGAYATV--SSQHLARRYAALAAEDCAAAARRFLLSSAAAAAASSSP 132

  Fly   175 ----------------------HHVMVGP----APPTGMPL--GAP------PTPTVKSIAKQMN 205
                                  ....|||    .||..:.|  |:|      ||..::.:.|:..
  Rat   133 ASCCKELGLAAAAAWEQQGRSLFLAGVGPVRFLGPPAAVQLFRGSPAPPQAEPTTVLEMVCKRKG 197

  Fly   206 ITIP--------------------------GGGVN-----------------------PGSPTFS 221
            ..:|                          |||.:                       |.||...
  Rat   198 AGVPACTPCKQPRCGGGGCGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPPPLCPAPASPASE 262

  Fly   222 TMGMVAAQKAAASAGGTPLQLRKQLP------------NP---HLHHPYGSMGINAASPLIMQHQ 271
            ...:.||...|..||||.....:|.|            ||   |...|.....||...|.|:
  Rat   263 CAPIEAAAGDAVRAGGTAPSSAQQQPESGDSDCQEPPENPCDCHREPPPEIPDINQLPPSIL--- 324

  Fly   272 LHPPPIHSIEQLMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELR 336
                 :.....|.||:|.||             .:.||..||| |....::|..|
  Rat   325 -----LKIFSNLSLDERCLS-------------ASLVCKYWRD-LCLDFQFWKQL---------- 360

  Fly   337 QMPGCDRGKLYNSLIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLRCSSISDRGLETLL 401
                                                           .||.| ..::|..||.:.
  Rat   361 -----------------------------------------------DLSSR-QQVTDELLEKIA 377

  Fly   402 DHLQSLFELELAGCNEVTEAGLWACL----TPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSL 462
            ...|::.|:.::.|..::::|:  |:    .|.::..:...|..::|.::.|||...|     .|
  Rat   378 SRSQNIVEINISDCRSMSDSGV--CVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCP-----LL 435

  Fly   463 QAYHVTDAALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDGVEL 527
            |..||.:..                     :||:.|:..:......|..:....|.|::|:|:.:
  Rat   436 QKVHVGNQD---------------------KLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMVV 479

  Fly   528 IAENLQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYISTMLSLTALFLR 592
            ||::..||:.:.:.....:||.|::..|.....|:.:....| .:|..||.:::.:.:|::|.||
  Rat   480 IAKSCLKLQRIYMQENKLVTDQSVKAFAEHCPDLQCVGFMGC-SVTSKGVIHLTKLRNLSSLDLR 543

  Fly   593 WCSQV------------RDFGLQHLC---------------SMRNLQVLSLAGCPLL------TS 624
            ..:::            ::....:||               ..::|:.|.|..|.:.      .|
  Rat   544 HITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQSLKELYLVSCKITDYGQRGNS 608

  Fly   625 SGLSSLIQLRHLQELELTNCPGASHELFDYLKEHLP 660
            ....:.:...|||     :||..   |.:.|.|.||
  Rat   609 GAAGTAVPSHHLQ-----HCPAG---LQEDLGESLP 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	6/23 (26%)
		AMN1	383..600	CDD:187754	47/232 (20%)
		leucine-rich repeat	431..456	CDD:275381	5/24 (21%)
		leucine-rich repeat	457..482	CDD:275381	4/24 (17%)
		leucine-rich repeat	483..508	CDD:275381	3/24 (13%)
		leucine-rich repeat	509..534	CDD:275381	7/24 (29%)
		leucine-rich repeat	535..560	CDD:275381	5/24 (21%)
		leucine-rich repeat	561..585	CDD:275381	5/23 (22%)
		leucine-rich repeat	586..610	CDD:275381	6/50 (12%)
		leucine-rich repeat	636..661	CDD:275381	9/25 (36%)
Fbxl17	XP_038939705.1	F-box-like	316..361	CDD:403981	18/123 (15%)
		leucine-rich repeat	357..382	CDD:275381	8/82 (10%)
		leucine-rich repeat	383..408	CDD:275381	4/26 (15%)
		AMN1	406..568	CDD:187754	36/188 (19%)
		leucine-rich repeat	409..434	CDD:275381	6/29 (21%)
		leucine-rich repeat	435..460	CDD:275381	7/45 (16%)
		leucine-rich repeat	461..486	CDD:275381	7/24 (29%)
		leucine-rich repeat	487..512	CDD:275381	5/24 (21%)
		leucine-rich repeat	513..536	CDD:275381	5/23 (22%)
		leucine-rich repeat	537..562	CDD:275381	4/24 (17%)
		leucine-rich repeat	563..588	CDD:275381	2/24 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810