DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and Kdm2b

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_038945396.1	Gene:	Kdm2b / 304495	RGDID:	1310217	Length:	1350	Species:	Rattus norvegicus

Alignment Length:	658	Identity:	135/658 - (20%)
Similarity:	230/658 - (34%)	Gaps:	168/658 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISAQGVVERASAELS-------KRINGLGLRSKHHHSSTSSGAGGAGDAASPAGATPTPAAPSGK 61
            :...|::.|.|.::.       ::...|..|.:.....||.|:........|.|::.:|...|..
  Rat   799 VPTDGILRRKSDDVHLRRKRKYEKPQELSARKRASTLQTSPGSSSHLSPRPPLGSSLSPWWRSSL 863

  Fly    62 TSVMERVTNALCGGGNSNSNSGSNSSNSNTSSASATAATSPASNANPP----------QTPDKP- 115
            |...:::            ..|...........|...|....|.||.|          ..|:.|
  Rat   864 TYFQQQL------------KPGKEDKLLRKKRRSWKNAEDRLSLANKPLRRFKQEPEDDLPEAPP 916

  Fly   116 -------SRGSSPSPG----GITMPGGQSQVQNSTHHLLQQQQQQQQHMQLQQSQQQHLQLQAST 169
                   ||.|||:.|    |...|..:.:|:......|..::..:   :|.:.....:|...||
  Rat   917 KTRESDQSRSSSPTAGPSTEGAEGPEEKRKVKMRRKRRLPNKELSK---ELSKELNHEIQKTEST 978

  Fly   170 LINSNHHVMVGPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQKAAAS 234
            |.:.||           .|:.:.|....:...:.::        :...|...:.|:
  Rat   979 LAHENH-----------QPIKSEPESENEEPKRPLS--------HCERPHRFSKGL--------- 1015

  Fly   235 AGGTPLQLRKQLPNPHLHHP---YGSMGINAASPLIMQ---HQLHPPPIH-SIEQLMLDD---RF 289
             .|||.:||..| .|.|..|   ......:.:.|..:|   |.:.||||. ..:.|.|||   ..
  Rat  1016 -NGTPRELRHSL-GPGLRSPPRVISRPPPSTSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHV 1078

  Fly   290 LSR-----FFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGKLYNS 349
            :.|     .|.|.|..:..:..:||..| :......|.|: .:....|:.:..:       :.:.
  Rat  1079 MHREVWMAVFSYLSHQDLCVCMRVCRTW-NRWCCDKRLWT-RIDLNHCKSITPL-------MLSG 1134

  Fly   350 LIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLRCSSISDRGLETLLDHLQSLFELELAG 414
            :|||.                     |:      ||.|..::||.:.|..|::.|..|.:|.|:|
  Rat  1135 IIRRQ---------------------PV------SLDLSWTNISKKQLSWLINRLPGLRDLVLSG 1172

  Fly   415 CNEVTEAGLWACLTPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQ 479
            |:.:..:.|.:...|.:.:|.:.....:.|      ||:...|..       .||.     .|.|
  Rat  1173 CSWIAVSALCSSSCPLLRTLDVQWVEGLKD------AQMRDLLSP-------PTDN-----RPGQ 1219

  Fly   480 SHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDGVELIAENLQKLRALDLSWCP 544
            ..:.|.||             |||.       |.|:|.. :||..:.||..::..|..|.||:|.
  Rat  1220 MDNRSKLR-------------NIVE-------LRLAGLD-ITDVSLRLIIRHMPLLSKLHLSYCN 1263

  Fly   545 RITDASLEYIAC----DLNQLEELTLDRCVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHL 605
            .:||.|:..:..    ..:.|.|:.|..|..:||..:.:.....::..:.||:|.||...|.:..
  Rat  1264 HVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQF 1328

  Fly   606 CSMRNLQV 613
            .:..::.|
  Rat  1329 IAEMSVSV 1336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	8/23 (35%)
		AMN1	383..600	CDD:187754	56/220 (25%)
		leucine-rich repeat	431..456	CDD:275381	4/24 (17%)
		leucine-rich repeat	457..482	CDD:275381	5/24 (21%)
		leucine-rich repeat	483..508	CDD:275381	6/24 (25%)
		leucine-rich repeat	509..534	CDD:275381	7/24 (29%)
		leucine-rich repeat	535..560	CDD:275381	8/28 (29%)
		leucine-rich repeat	561..585	CDD:275381	6/23 (26%)
		leucine-rich repeat	586..610	CDD:275381	6/23 (26%)
		leucine-rich repeat	636..661	CDD:275381
Kdm2b	XP_038945396.1	JmjC	151..226	CDD:214721
		cupin_RmlC-like	198..304	CDD:424065
		JHD	303..>338	CDD:407680
		CTD_KDM2B	476..584	CDD:412026
		zf-CXXC	<626..662	CDD:366873
		PHD_KDM2B	672..733	CDD:277114
		PTZ00449	<731..967	CDD:185628	33/182 (18%)
		F-box-like	1082..1120	CDD:403981	8/39 (21%)
		leucine-rich repeat	1116..1140	CDD:275381	5/52 (10%)
		AMN1	1132..1321	CDD:187754	59/254 (23%)
		leucine-rich repeat	1141..1164	CDD:275381	8/28 (29%)
		leucine-rich repeat	1165..1188	CDD:275381	6/22 (27%)
		leucine-rich repeat	1189..1228	CDD:275381	12/69 (17%)
		leucine-rich repeat	1229..1253	CDD:275381	9/31 (29%)
		leucine-rich repeat	1254..1283	CDD:275381	8/28 (29%)
		leucine-rich repeat	1284..1308	CDD:275381	6/23 (26%)
		leucine-rich repeat	1309..1333	CDD:275381	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810