DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and FBXL4

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001265645.1	Gene:	FBXL4 / 26235	HGNCID:	13601	Length:	621	Species:	Homo sapiens

Alignment Length:	525	Identity:	126/525 - (24%)
Similarity:	197/525 - (37%)	Gaps:	135/525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 TVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQKAAASAGGTPLQLRKQLPNPHLHHPYGSMGI 260
            |:.::|...|: .|..|....:..|.|.|....|..:||     |..::..||      :.|...
Human    74 TMWNLAGVPNV-FPSSGDFTQTAVFRTYGTWWDQCPSAS-----LPFKRTPPN------FQSQDY 126

  Fly   261 NAASPLIMQHQLHPPPIHSIEQLMLDDRFLSRFFQYFSPYERRILAQVC------------IKWR 313
               ..|..:.|::|..:|.:|             .|......||||  |            ::|.
Human   127 ---VELTFEQQVYPTAVHVLE-------------TYHPGAVIRILA--CSANPYSPNPPAEVRWE 173

  Fly   314 DTLYRSPRYWSGLLPTLQCRELRQMPGCDRG-KLYNSLIRRGFHALGLVGASDEDALDVVHSFPL 377
                   ..||.....:...:.||...|.:. ....:|||...::..|...::.||: |:|.  :
Human   174 -------ILWSERPTKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYTELDAV-VLHG--V 228

  Fly   378 ASKHVHSLSLRCSSISDRGLE---------TLLDHLQSLFELELAGCNEVTEAGLWACLTPRIVS 433
            ..|.|  |||:.|.|....:|         ..:|.|...|...:.|  |....|.:..|...::.
Human   229 KDKPV--LSLKTSLIDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLG--EGPNNGYFDKLPYELIQ 289

  Fly   434 -----LSLADCINIADEAVGAVAQLL------PSLY-EFSLQAY--HVTDAALGYFSPKQSHSLS 484
                 |:|.|...:|.     ..:||      |..| ..:||.|  .:.|.:|.:.   ||....
Human   290 LILNHLTLPDLCRLAQ-----TCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFL---QSRCTL 346

  Fly   485 ILRLQSCWELTNHGIVNIVHSLPHLTV-------LSLSGCSKLTDDGVELIAENLQKLRALDLSW 542
            :..|...| ..|.|.:::......|.|       |.||....|.:..:|:|:|....|:||:||.
Human   347 VQWLNLSW-TGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSS 410

  Fly   543 CPRITDASLEYIA--CDL----------------------NQLEELTLDRCVHITDIGVGYISTM 583
            |.::...:..:||  |.|                      ::|:.|:|..||.|.|..|  |::|
Human   411 CDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDV--IASM 473

  Fly   584 LSLTALFLR----W-CSQVRDFGLQHL---CSMRNLQVLSLAGCPLLTSS-GLSSLI--QLRHLQ 637
            :......||    | |..:.:.|:..|   |.:  |:.|.|..||.|.|| |..:.:  ||.:||
Human   474 IGAKCKKLRTLDLWRCKNITENGIAELASGCPL--LEELDLGWCPTLQSSTGCFTRLAHQLPNLQ 536

  Fly   638 ELELT 642
            :|.||
Human   537 KLFLT 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	9/32 (28%)
		AMN1	383..600	CDD:187754	65/275 (24%)
		leucine-rich repeat	431..456	CDD:275381	6/35 (17%)
		leucine-rich repeat	457..482	CDD:275381	8/27 (30%)
		leucine-rich repeat	483..508	CDD:275381	4/24 (17%)
		leucine-rich repeat	509..534	CDD:275381	9/31 (29%)
		leucine-rich repeat	535..560	CDD:275381	10/48 (21%)
		leucine-rich repeat	561..585	CDD:275381	10/23 (43%)
		leucine-rich repeat	586..610	CDD:275381	7/31 (23%)
		leucine-rich repeat	636..661	CDD:275381	5/7 (71%)
FBXL4	NP_001265645.1	F-box-like	280..318	CDD:315592	7/42 (17%)
		leucine-rich repeat	295..317	CDD:275381	6/26 (23%)
		leucine-rich repeat	318..346	CDD:275381	8/30 (27%)
		leucine-rich repeat	347..376	CDD:275381	6/29 (21%)
		LRR 1	376..397		5/20 (25%)
		leucine-rich repeat	377..398	CDD:275381	6/20 (30%)
		AMN1	394..601	CDD:332986	46/152 (30%)
		LRR 2	402..421		6/18 (33%)
		leucine-rich repeat	403..427	CDD:275381	8/23 (35%)
		LRR 3	427..448		1/20 (5%)
		leucine-rich repeat	428..452	CDD:275381	1/23 (4%)
		LRR 4	452..474		9/23 (39%)
		leucine-rich repeat	453..480	CDD:275381	10/28 (36%)
		LRR 5	480..501		5/20 (25%)
		leucine-rich repeat	481..506	CDD:275381	7/24 (29%)
		LRR 6	504..524		9/21 (43%)
		leucine-rich repeat	507..534	CDD:275381	11/26 (42%)
		LRR 7	532..558		6/10 (60%)
		leucine-rich repeat	535..560	CDD:275381	5/7 (71%)
		LRR 8	559..583
		leucine-rich repeat	561..586	CDD:275381
		LRR 9	584..609
		leucine-rich repeat	587..612	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810