DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG32085 and FBXL5

DIOPT Version :9

Sequence 1:NP_729732.1 Gene:CG32085 / 39311 FlyBaseID:FBgn0052085 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_036293.1 Gene:FBXL5 / 26234 HGNCID:13602 Length:691 Species:Homo sapiens


Alignment Length:534 Identity:105/534 - (19%)
Similarity:160/534 - (29%) Gaps:231/534 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 HPPPIHSIEQLMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCR---- 333
            |.||     ::||.      .|.|.:|.|....:||.:|| ..|.::...|..|.|....|    
Human   207 HLPP-----EVMLS------IFSYLNPQELCRCSQVSMKW-SQLTKTGSLWKHLYPVHWARGDWY 259

  Fly   334 -----ELRQMPGCD--RGKLYNSLIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLRCSS 391
                 ||...|..:  :.:...|   |.||..      |||| |:..|...|.:   |:::..:.
Human   260 SGPATELDTEPDDEWVKNRKDES---RAFHEW------DEDA-DIDESEESAEE---SIAISIAQ 311

  Fly   392 ISDRGLETLLDHLQSLFELELAGCNEVTEAGLWACLTPRIVSLSLADCINIADEAVGAVAQLLPS 456
            :..|.|..|:.::     |...|.:              :.:|.||....::.:.|..:.:|.|:
Human   312 MEKRLLHGLIHNV-----LPYVGTS--------------VKTLVLAYSSAVSSKMVRQILELCPN 357

  Fly   457 LYEFSLQAYHVTDAALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLT 521
            |....|....::|:|...:|               |       :....||.|   |.||||.|:|
Human   358 LEHLDLTQTDISDSAFDSWS---------------W-------LGCCQSLRH---LDLSGCEKIT 397

  Fly   522 DDGVELIAENLQKL-------------RALDLSWCPR-ITDASLEYIAC---------------- 556
            |..:|.|:..|..|             :....:|..: ||..|.:..||                
Human   398 DVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNE 462

  Fly   557 -----------------------DLNQLEELTLDR-------CV--------------------- 570
                                   ||..:|:....|       ||                     
Human   463 HPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVG 527

  Fly   571 ---------HITDIGVGY-----------ISTMLSLTA--------------------------- 588
                     |.......|           :.||.||..                           
Human   528 LRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKS 592

  Fly   589 ----------LFLRWCSQVRDFGLQHLC---SMRNLQVLSLAGCPLLTSSGLSSLIQLRHLQELE 640
                      |.|..|.|:.|.||:.|.   .:..|:.|:|:||..:|.:||..|:         
Human   593 DQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLV--------- 648

  Fly   641 LTNCPGASHELFDY 654
             :.||..:.|.|.|
Human   649 -SACPSLNDEYFYY 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32085NP_729732.1 leucine-rich repeat 382..406 CDD:275381 4/23 (17%)
AMN1 383..600 CDD:187754 55/354 (16%)
leucine-rich repeat 431..456 CDD:275381 5/24 (21%)
leucine-rich repeat 457..482 CDD:275381 5/24 (21%)
leucine-rich repeat 483..508 CDD:275381 3/24 (13%)
leucine-rich repeat 509..534 CDD:275381 11/24 (46%)
leucine-rich repeat 535..560 CDD:275381 9/77 (12%)
leucine-rich repeat 561..585 CDD:275381 8/71 (11%)
leucine-rich repeat 586..610 CDD:275381 9/63 (14%)
leucine-rich repeat 636..661 CDD:275381 5/19 (26%)
FBXL5NP_036293.1 Hemerythrin-like 1..159
Hr_FBXL5 7..160 CDD:213984
F-box-like 205..249 CDD:289689 15/53 (28%)
leucine-rich repeat 332..357 CDD:275381 5/24 (21%)
LRR 1 340..364 4/23 (17%)
AMN1 354..>408 CDD:187754 21/78 (27%)
leucine-rich repeat 358..384 CDD:275381 6/47 (13%)
LRR 2 365..392 9/51 (18%)
leucine-rich repeat 385..435 CDD:275381 15/52 (29%)
LRR 3 393..418 8/24 (33%)
leucine-rich repeat 436..500 CDD:275381 9/63 (14%)
LRR 4 479..508 6/28 (21%)
leucine-rich repeat 501..537 CDD:275381 2/35 (6%)
leucine-rich repeat 538..583 CDD:275381 5/44 (11%)
LRR 5 576..607 2/30 (7%)
leucine-rich repeat 584..627 CDD:275381 8/42 (19%)
AMN1 <603..>654 CDD:187754 19/60 (32%)
LRR 6 608..635 9/26 (35%)
leucine-rich repeat 628..653 CDD:275381 10/34 (29%)
LRR 7 636..661 9/34 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1282076at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

Return to query results.
Submit another query.