DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32085 and FBXL6

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_036294.2	Gene:	FBXL6 / 26233	HGNCID:	13603	Length:	539	Species:	Homo sapiens

Alignment Length:	626	Identity:	130/626 - (20%)
Similarity:	197/626 - (31%)	Gaps:	242/626 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 ASNANPPQTPDKPSRGSSPSPGGITMPGGQSQVQNSTHHLLQQQQQQQQHMQLQQSQQQHLQLQA 167
            ||...|.|.|..||..:.|..|
Human    63 ASRRTPRQPPRGPSAAAKPKAG------------------------------------------- 84

  Fly   168 STLINSNHHVMVGPAP-PTGMPLGAPPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAA--- 228
               :.|.......||| ||..|...|.......|..::.:.|.|..|....| ...:|..|.
Human    85 ---LRSEAAAAPAPAPAPTPTPEEGPDAGWGDRIPLEILVQIFGLLVAADGP-MPFLGRAARVCR 145

  Fly   229 --QKAAASAGGTPLQLRKQLPNPHLHHPYGSMGINAASPLI---------MQHQLHPPPIHSIEQ 282
              |:||:              .|.|.|.     :..:|||:         .:.:|    :.|:|.
Human   146 RWQEAAS--------------QPALWHT-----VTLSSPLVGRPAKGGVKAEKKL----LASLEW 187

  Fly   283 LMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQ-----CRELR--QMPG 340
            ||.:         .||..:|..|    |.|:..::          |.|:     |..|.  ::.|
Human   188 LMPN---------RFSQLQRLTL----IHWKSQVH----------PVLKLVGECCPRLTFLKLSG 229

  Fly   341 CDRGKLYNSLIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLRCSSISDRGLETLLDHLQ 405
            |              |.:      ..|||.::..   |...:|||.|:.|.:....:.:.|:
Human   230 C--------------HGV------TADALVMLAK---ACCQLHSLDLQHSMVESTAVVSFLE--- 268

  Fly   406 SLFELELAGCNEVTEAG-----LW---ACLTPRIVSLSLADC---INIADEAVGAVAQLLPSLYE 459
                          |||     ||   :..|..|:...|..|   :.:.:.:.|.....:|  .:
Human   269 --------------EAGSRMRKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIP--LQ 317

  Fly   460 FSLQAYHVTDAALGYFSPKQSHSLSILRLQSCWEL---TNHGIVNIVHSLPHLTVLSL--SGCSK 519
            ..::|..           |....|.:|||.:...|   ...|:.. ....|.|..|.|  |.|:.
Human   318 LPVEALQ-----------KGCPQLQVLRLLNLMWLPKPPGRGVAP-GPGFPSLEELCLASSTCNF 370

  Fly   520 LTDDGVELIAENLQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYISTML 584
            ::::.:..:......||.|||..|.|||.|.|:.:.|  .:||:|      |:...|.....|:.
Human   371 VSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLPC--RELEQL------HLGLYGTSDRLTLA 427

  Fly   585 SLTALFL--RWCSQVRDFGL-----------------------QH--LCSMRNLQVLSLAGCPLL 622
            ...:.||  :||..:|:..|                       .|  |||      |:|.| ..:
Human   428 KEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAFLSTPGGSHPALCS------LNLRG-TRV 485

  Fly   623 TSSGLSSLIQLRHLQELELTNCPGASHELFDYLKEHLPRCL 663
            |.|.:||:|          :.|||..     ||.....|||
Human   486 TPSTVSSVI----------SGCPGLL-----YLNLESCRCL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	6/23 (26%)
		AMN1	383..600	CDD:187754	54/234 (23%)
		leucine-rich repeat	431..456	CDD:275381	4/27 (15%)
		leucine-rich repeat	457..482	CDD:275381	2/24 (8%)
		leucine-rich repeat	483..508	CDD:275381	6/27 (22%)
		leucine-rich repeat	509..534	CDD:275381	5/26 (19%)
		leucine-rich repeat	535..560	CDD:275381	12/24 (50%)
		leucine-rich repeat	561..585	CDD:275381	6/23 (26%)
		leucine-rich repeat	586..610	CDD:275381	10/50 (20%)
		leucine-rich repeat	636..661	CDD:275381	5/24 (21%)
FBXL6	NP_036294.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..111		17/93 (18%)
		F-box-like	113..163	CDD:289689	13/69 (19%)
		LRR 1	177..203		9/42 (21%)
		AMN1	185..398	CDD:187754	58/289 (20%)
		leucine-rich repeat	196..221	CDD:275381	7/38 (18%)
		LRR 2	204..229		5/34 (15%)
		leucine-rich repeat	222..247	CDD:275381	8/47 (17%)
		LRR 3	230..255		10/47 (21%)
		leucine-rich repeat	248..299	CDD:275381	15/67 (22%)
		LRR 4	281..307		4/25 (16%)
		leucine-rich repeat	300..329	CDD:275381	4/41 (10%)
		LRR 5	312..337		7/37 (19%)
		leucine-rich repeat	330..357	CDD:275381	6/27 (22%)
		LRR 6	341..365		6/24 (25%)
		AMN1	<357..508	CDD:187754	46/180 (26%)
		leucine-rich repeat	358..385	CDD:275381	5/26 (19%)
		LRR 7	368..393		6/24 (25%)
		leucine-rich repeat	386..409	CDD:275381	12/24 (50%)
		LRR 8	394..419		11/32 (34%)
		LRR 9	423..449		7/25 (28%)
		leucine-rich repeat	442..474	CDD:275381	3/31 (10%)
		LRR 10	453..481		5/33 (15%)
		leucine-rich repeat	475..499	CDD:275381	12/40 (30%)
		LRR 11	482..507		11/40 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810