DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and pof2

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_596079.1	Gene:	pof2 / 2540355	PomBaseID:	SPBC25B2.11	Length:	463	Species:	Schizosaccharomyces pombe

Alignment Length:	414	Identity:	92/414 - (22%)
Similarity:	158/414 - (38%)	Gaps:	128/414 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 YFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGKLYNSLIRRGFHALGL 360
            |....|.|..:.||..||:.          ::|||..:.:.|    :..:|.|.     |..|
pombe    14 YLEADELRCKSTVCTSWRNF----------IIPTLWEKVVFQ----NEAQLNNF-----FDTL-- 57

  Fly   361 VGASDEDALDVVHSFPLASKHVHSLSLRCSSI----SDRGLETLLDHLQSLFELELAGCNEVTEA 421
                 :.:.||.:.|....|      |.||.:    :|:.| .|:.....:..|.|:||..::|
pombe    58 -----QYSKDVSYYFRYLRK------LNCSRVRKFLTDKHL-MLMTLATGISRLNLSGCTRISE- 109

  Fly   422 GLWACLTPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQSHSLSIL 486
                   |.|..| |...:|:.......:..|..::.|:      ::|         ...:|..|
pombe   110 -------PLIGKL-LYQNLNLVTINFSNIFSLPANILEY------ISD---------NCPNLKAL 151

  Fly   487 RLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDGVELIAE--------------------- 530
            .:.:|..:.:.|:|.|:...|:|..|.:..|.||||..:::::|
pombe   152 NIGNCGLVEDTGMVQIIKRCPYLNRLIIPNCRKLTDVSLQILSEKEDLIELDISGCEGFHNADTL 216

  Fly   531 --------------------------------NLQKLRALDLSWCPRITDASLEYIACDLNQLEE 563
                                            .|..:|||.|:..|.:.|:.:|.|.|..::|..
pombe   217 SRLVSRNRGLKELSMDGCTELSHFITFLNLNCELDAMRALSLNNLPDLKDSDIELITCKFSKLNS 281

  Fly   564 LTLDRCVHITDIGVGYISTML-------SLTALFLRWCSQVRDFGLQHLC-SMRNLQVLSLAGCP 620
            |.|.:|:.:||      |::|       |||.|.|..|.::.|.|:|.|. |.:|:..:...||.
pombe   282 LFLSKCIGLTD------SSLLSLTKLSQSLTTLHLGHCYEITDIGVQCLLKSCKNITYIDFGGCL 340

  Fly   621 LLTSSGLSSLIQLRHLQELELTNC 644
            .|:...:|::.:|.:||.:.|..|
pombe   341 RLSDIAVSAIAKLPYLQRVGLVKC 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	6/27 (22%)
		AMN1	383..600	CDD:187754	58/280 (21%)
		leucine-rich repeat	431..456	CDD:275381	5/24 (21%)
		leucine-rich repeat	457..482	CDD:275381	2/24 (8%)
		leucine-rich repeat	483..508	CDD:275381	6/24 (25%)
		leucine-rich repeat	509..534	CDD:275381	9/77 (12%)
		leucine-rich repeat	535..560	CDD:275381	9/24 (38%)
		leucine-rich repeat	561..585	CDD:275381	8/30 (27%)
		leucine-rich repeat	586..610	CDD:275381	10/24 (42%)
		leucine-rich repeat	636..661	CDD:275381	4/9 (44%)
pof2	NP_596079.1	F-box-like	2..45	CDD:289689	10/40 (25%)
		leucine-rich repeat	96..121	CDD:275381	9/33 (27%)
		leucine-rich repeat	122..141	CDD:275381	2/24 (8%)
		AMN1	<143..292	CDD:187754	30/157 (19%)
		leucine-rich repeat	148..173	CDD:275381	6/24 (25%)
		leucine-rich repeat	174..225	CDD:275381	8/50 (16%)
		leucine-rich repeat	226..278	CDD:275381	10/51 (20%)
		AMN1	<278..428	CDD:187754	29/93 (31%)
		leucine-rich repeat	279..304	CDD:275381	8/30 (27%)
		leucine-rich repeat	305..330	CDD:275381	10/24 (42%)
		leucine-rich repeat	331..355	CDD:275381	5/23 (22%)
		leucine-rich repeat	356..382	CDD:275381	4/9 (44%)
		leucine-rich repeat	383..408	CDD:275381
		leucine-rich repeat	409..427	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47209
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900