DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and Lrrc29

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001355337.1	Gene:	Lrrc29 / 234684	MGIID:	2443262	Length:	621	Species:	Mus musculus

Alignment Length:	599	Identity:	149/599 - (24%)
Similarity:	222/599 - (37%)	Gaps:	159/599 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 QLQQSQQQHLQLQASTLINSNHHVMVGPAPPT-----GMPLGAPPTPTVKSIAKQMNITIPGGGV 213
            |:.||...||.....:|       .:|...||     .:.||.|       :.:.::::
Mouse    83 QVLQSVAYHLGPHLESL-------CLGGGSPTEASFLALILGCP-------VLRTLDLS------ 127

  Fly   214 NPGSPTFSTMGMVAAQKAAAS------AGGTPLQLR-----KQLPNPHLHHPYGSMGINAASPLI 267
              |..:..|.|.:.||...|.      :|...|.|.     ..|...||...:.|:...:.:...
Mouse   128 --GCNSLFTSGTLLAQPETAQCVREALSGLRDLNLAGLRDLTDLSFNHLSSCFPSLERLSLAYCH 190

  Fly   268 MQHQLHP------PPIHSIEQLMLDDRFLSRFFQY--------------FSPYERRILAQVC-IK 311
            :..:|.|      |.:.|..||...:  |.:|.:.              ..|...:.|.||. :|
Mouse   191 LSFELSPTWGSISPQVSSPSQLSFHN--LLKFIKERAGTLRALDLSGTGLPPEALQALGQVTGLK 253

  Fly   312 WRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGKLYNSLIRRGFHALGLVGASD--EDALDVVHS 374
            ..:....|.|..|....|:.|   ||.|              |..:|.|.|.||  :.||..|..
Mouse   254 LEELYLHSCRDLSSEAVTILC---RQQP--------------GLTSLDLSGCSDLTDGALLAVSR 301

  Fly   375 FPLASKHVHSLSL-RCSSISDRGLETL--LDHLQSLFELELAGCNEVTEAGLWACL-----TPR- 430
               ..:|:..||| :...::|.|...|  |..|||   |::|.|..|:...|...|     .||
Mouse   302 ---GLRHLRHLSLKKLQRLTDAGCAALGALRELQS---LDMAECCLVSGRELAQVLGSVRRAPRA 360

  Fly   431 IVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQSHSLSILRLQSCWELT 495
            :.||.||.|.::.|   .:|..::|:|                      ..||.:|.|.||..||
Mouse   361 LTSLRLAYCSSLKD---ASVLSMIPAL----------------------GPSLKVLDLSSCMALT 400

  Fly   496 NHGIVNIVHSLPHLTVLSLSGCSKLTDDGVELIAE------------------------------ 530
            |..:..|...|.||:||.|:.|.:|.|.|:..:.|
Mouse   401 NQTMQAICTYLIHLSVLRLAWCKELQDWGLLGLKEPSDEPVLSPQLHQKVDNEAPDPQEPSSEPQ 465

  Fly   531 -----NLQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIG-VGYISTMLSLTAL 589
                 .||.|:.|||:.|.::|||||..: ....||.:|:|......||.| |.......||..|
Mouse   466 GSSLLMLQALQELDLTACSKLTDASLAKV-LQFPQLRQLSLSLLPAFTDTGLVAVARGCPSLERL 529

  Fly   590 FLRWCSQVRDFGLQHLCSM-RNLQVLSLAGCPLLTSSGLSSLIQ-LRHLQELELTNCPGASHELF 652
            .|..||.:.|.|......: ..||.|:|:.|..||...|.::.| .:.|:.|::..|||.:....
Mouse   530 TLSHCSHLSDEGWAQAARLWPRLQHLNLSSCSQLTEQTLDTIGQACKQLRVLDVAMCPGINMAAV 594

  Fly   653 DYLKEHLPRCLIIE 666
            .:.:..||:...|:
Mouse   595 RHFQAQLPQVTCIQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	8/26 (31%)
		AMN1	383..600	CDD:187754	74/261 (28%)
		leucine-rich repeat	431..456	CDD:275381	7/24 (29%)
		leucine-rich repeat	457..482	CDD:275381	1/24 (4%)
		leucine-rich repeat	483..508	CDD:275381	10/24 (42%)
		leucine-rich repeat	509..534	CDD:275381	10/59 (17%)
		leucine-rich repeat	535..560	CDD:275381	10/24 (42%)
		leucine-rich repeat	561..585	CDD:275381	7/24 (29%)
		leucine-rich repeat	586..610	CDD:275381	7/24 (29%)
		leucine-rich repeat	636..661	CDD:275381	6/24 (25%)
Lrrc29	NP_001355337.1	F-box-like	3..38	CDD:372399
		leucine-rich repeat	70..83	CDD:275381	149/599 (25%)
		LRR_RI	<118..360	CDD:393385	62/281 (22%)
		leucine-rich repeat	121..154	CDD:275381	6/40 (15%)
		leucine-rich repeat	155..180	CDD:275381	5/24 (21%)
		leucine-rich repeat	181..227	CDD:275381	8/47 (17%)
		leucine-rich repeat	228..248	CDD:275381	2/19 (11%)
		AMN1	240..428	CDD:187754	68/235 (29%)
		leucine-rich repeat	254..277	CDD:275381	6/25 (24%)
		leucine-rich repeat	280..305	CDD:275381	8/27 (30%)
		leucine-rich repeat	306..360	CDD:275381	17/56 (30%)
		leucine-rich repeat	331..356	CDD:275381	9/27 (33%)
		leucine-rich repeat	361..387	CDD:275381	9/50 (18%)
		leucine-rich repeat	388..413	CDD:275381	10/24 (42%)
		leucine-rich repeat	414..474	CDD:275381	10/59 (17%)
		AMN1	<475..589	CDD:187754	39/114 (34%)
		leucine-rich repeat	475..525	CDD:275381	18/50 (36%)
		leucine-rich repeat	526..551	CDD:275381	7/24 (29%)
		leucine-rich repeat	552..577	CDD:275381	9/24 (38%)
		leucine-rich repeat	578..603	CDD:275381	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900