DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and Amn1

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001106895.1	Gene:	Amn1 / 232566	MGIID:	2442933	Length:	258	Species:	Mus musculus

Alignment Length:	295	Identity:	70/295 - (23%)
Similarity:	115/295 - (38%)	Gaps:	98/295 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 SKHVHSLSLRCSSISDRGLETLLDHLQSLFELELAGCNEVTEAGLWACLTPRIVSLSLADCINIA 443
            |:::..:....|:|.||.::.          :.:.|  .:|::.:...|.|.:..|.|..|
Mouse    23 SRYISDIKYLPSNIKDRLIKI----------MSIRG--RITDSNISEVLHPEVQRLDLRSC---- 71

  Fly   444 DEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQSHSLSILRLQSCWE----LTNHGIVNIVH 504
                                  .::|.||.:..  :...|..|.|:||.|    :|:.||..:..
Mouse    72 ----------------------DISDVALQHLC--KCRKLKALNLKSCREHRNSITSEGIKAVAS 112

  Fly   505 SLPHLTVLSLSGCSKLTDDGVELIAENLQKLRALDLSWCPRITDASLE-------YIAC-DLN-- 559
            |...|..:.|.||..:||:||..:|.|...|:.:||..|..|||.||.       ::.| |::
Mouse   113 SCSDLHEIYLKGCCSVTDEGVLALALNCHLLKIIDLGGCLGITDVSLHALGKNCPFLQCVDISTT 177

  Fly   560 -----------------QLEELTLDRCVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHLCS 607
                             ||||:.:..|:::||..|     ..:|||     |.::        |
Mouse   178 QVSDNGVVALVSGPCAKQLEEINMRYCINLTDKAV-----EAALTA-----CPRI--------C- 223

  Fly   608 MRNLQVLSLAGCPLLTSSG---LSSLIQLRHLQEL 639
                 :|...||||:|...   |..||..|.|:::
Mouse   224 -----ILLFHGCPLITDRSQEVLEQLIGSRKLKQV 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	4/23 (17%)
		AMN1	383..600	CDD:187754	57/247 (23%)
		leucine-rich repeat	431..456	CDD:275381	3/24 (13%)
		leucine-rich repeat	457..482	CDD:275381	3/24 (13%)
		leucine-rich repeat	483..508	CDD:275381	10/28 (36%)
		leucine-rich repeat	509..534	CDD:275381	10/24 (42%)
		leucine-rich repeat	535..560	CDD:275381	11/51 (22%)
		leucine-rich repeat	561..585	CDD:275381	7/23 (30%)
		leucine-rich repeat	586..610	CDD:275381	5/23 (22%)
		leucine-rich repeat	636..661	CDD:275381	1/4 (25%)
Amn1	NP_001106895.1	leucine-rich repeat	15..38	CDD:275381	3/14 (21%)
		AMN1	37..257	CDD:187754	67/281 (24%)
		leucine-rich repeat	63..86	CDD:275381	6/50 (12%)
		leucine-rich repeat	87..116	CDD:275381	10/28 (36%)
		leucine-rich repeat	117..142	CDD:275381	10/24 (42%)
		leucine-rich repeat	143..168	CDD:275381	9/24 (38%)
		leucine-rich repeat	169..195	CDD:275381	2/25 (8%)
		leucine-rich repeat	196..221	CDD:275381	11/34 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900