DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and KDM2A

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_036440.1	Gene:	KDM2A / 22992	HGNCID:	13606	Length:	1162	Species:	Homo sapiens

Alignment Length:	585	Identity:	117/585 - (20%)
Similarity:	199/585 - (34%)	Gaps:	193/585 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 CGGGNSNSNSGSNSSNSNTSSASATAATSPASNANPPQTPDKPSRGS------SP-SPGGI---T 127
            |...:|:..:.......:...|.......|..:.:.|.||...|..|      .| ||.|:   :
Human   675 CYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRS 739

  Fly   128 MPGGQSQVQNSTHHLLQQQQQQQQHMQLQQSQQQHLQLQAS--TLINSNHHVMVGPAPPTGMPLG 190
            .||...    |.||...:.::.:        ::|.|:|||:  |::....:      .|:|.
Human   740 SPGAGP----SDHHSASRDERFK--------RRQLLRLQATERTMVREKEN------NPSGK--- 783

  Fly   191 APPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQKAAASAGGTPLQLRKQ---LPNPHLH 252
                   |.:::.....|.|..:.           |..|:......||.:..:.|   ..:.:|.
Human   784 -------KELSEVEKAKIRGSYLT-----------VTLQRPTKELHGTSIVPKLQAITASSANLR 830

  Fly   253 HPYGSMGINAASP-LIMQHQLHPPPIHSIEQLM-------------------------------- 284
            |          || :::||.....|....|:.:
Human   831 H----------SPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWA 885

  Fly   285 --LDDRFLSR-----FFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCD 342
              .|:.::.|     .|:|.|..|.....:||..|    |:    |        |        ||
Human   886 QDGDESWMQREVWMSVFRYLSRRELCECMRVCKTW----YK----W--------C--------CD 926

  Fly   343 RGKLYNSLIRRGFHALGLVGASDEDALD-VVHSFPLASKHVHSLSLRCSSISDRGLETLLDHLQS 406
            : :|:..:      .|....|....||. ::...|:      ||.|..::||.:.|..|::.|..
Human   927 K-RLWTKI------DLSRCKAIVPQALSGIIKRQPV------SLDLSWTNISKKQLTWLVNRLPG 978

  Fly   407 LFELELAGCNEVTEAGLWACLTPRIVSLSLADCINIADEAVGAV------------AQLLPSLYE 459
            |.:|.||||:....:.|.....|.:.:|.|...:.|.|..:..:            ...|.::.:
Human   979 LKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTD 1043

  Fly   460 FSLQAYHVTDAALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDG 524
            |.|....:|||.              |||             |:..:|.|:.|.||.||.|||..
Human  1044 FRLAGLDITDAT--------------LRL-------------IIRHMPLLSRLDLSHCSHLTDQS 1081

  Fly   525 VELI----AENLQKLRALDLSWCPRITDASLEYI-------ACDLNQLEELTLDRCVH-ITDIGV 577
            ..|:    :.....|..|:::.|.::||.:|.|:       ..||...:::|...|.| |:|:.:
Human  1082 SNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHFISDLSI 1146

Fly 578 577
Human 1147 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	8/23 (35%)
		AMN1	383..600	CDD:187754	55/219 (25%)
		leucine-rich repeat	431..456	CDD:275381	5/36 (14%)
		leucine-rich repeat	457..482	CDD:275381	5/24 (21%)
		leucine-rich repeat	483..508	CDD:275381	4/24 (17%)
		leucine-rich repeat	509..534	CDD:275381	10/28 (36%)
		leucine-rich repeat	535..560	CDD:275381	9/31 (29%)
		leucine-rich repeat	561..585	CDD:275381	5/18 (28%)
		leucine-rich repeat	586..610	CDD:275381
		leucine-rich repeat	636..661	CDD:275381
KDM2A	NP_036440.1	cupin_like	199..299	CDD:328732
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..389
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..557
		zf-CXXC	<576..609	CDD:251032
		PHD_KDM2A	619..675	CDD:277113	117/585 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..789		24/112 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..887		3/47 (6%)
		F-box-like	896..934	CDD:315592	13/68 (19%)
		leucine-rich repeat	930..954	CDD:275381	4/29 (14%)
		AMN1	932..1138	CDD:332986	56/244 (23%)
		leucine-rich repeat	955..978	CDD:275381	8/28 (29%)
		LRR 1	961..982		6/20 (30%)
		leucine-rich repeat	979..1002	CDD:275381	7/22 (32%)
		LRR 2	984..1010		8/25 (32%)
		leucine-rich repeat	1003..1040	CDD:275381	5/36 (14%)
		leucine-rich repeat	1041..1065	CDD:275381	9/50 (18%)
		LRR 3	1048..1073		11/51 (22%)
		leucine-rich repeat	1066..1095	CDD:275381	10/28 (36%)
		LRR 4	1074..1103		8/28 (29%)
		leucine-rich repeat	1096..1120	CDD:275381	7/23 (30%)
		LRR 5	1104..1128		7/23 (30%)
		leucine-rich repeat	1121..1140	CDD:275381	4/18 (22%)
		LRR 6	1129..1156		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810