DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and FBXL13

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001381423.1	Gene:	FBXL13 / 222235	HGNCID:	21658	Length:	825	Species:	Homo sapiens

Alignment Length:	502	Identity:	113/502 - (22%)
Similarity:	198/502 - (39%)	Gaps:	133/502 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 MLDDRFLSRFFQYFSPYERRILAQVCIKWR-----DTLYRSPRYWS--GLLP------TLQCREL 335
            :|.:|.:.:.|.|.|..:..|..||...|.     ::|:.:..:.|  .::|      |||...|
Human   247 LLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRL 311

  Fly   336 R----QMPGC-DRGKLYNSLIR-RGFHALGLVGA---SDEDALDVVHSFP--------------- 376
            .    ...|| .|.|.:.|:.. |....|.:...   :||....:....|
Human   312 NVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNR 376

  Fly   377 ---LASKHVH---SLSLR-CSSISDRGLE--TLLDHLQSLFELELAGCNEVTEAGLW----ACLT 428
               |..:|.|   :|||. |...:|:||:  .|.:....|..|:|:||.:::..|..    :|
Human   377 TMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSC-- 439

  Fly   429 PRIVSLSLADCINIADEAVGAVAQL-----------LPSLYEFSLQAY--------------HVT 468
            ..|:.|::.|...:.|..|.|:.:.           .|.:.:.:.:|.              .||
Human   440 TGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVT 504

  Fly   469 DAALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDGVELIAEN-- 531
            ||:. .|..|...:||.:.:..|..:|:..:.:: ..|..||||:|:.|.::.|.|::...:.
Human   505 DASF-KFIDKNYPNLSHIYMADCKGITDSSLRSL-SPLKQLTVLNLANCVRIGDMGLKQFLDGPA 567

  Fly   532 LQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYISTMLSLTALFLRW--- 593
            ..::|.|:||.|.|::|||:..::.....|..|:|..|.|:|..|:|||..:.||.::.|..
Human   568 SMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDI 632

  Fly   594 ---------------------CSQVRDFGLQHLCSMR---------------------------N 610
                                 |.::.|.|:|..|...                           |
Human   633 SNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCIN 697

  Fly   611 LQVLSLAGCPLLTSSGLSSL-IQLRHLQELELTNCPGASHELFDYLK 656
            |..||:||||.:|.|.:..| .:..:|..|:::.|...:.::.:.|:
Human   698 LTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQ 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	9/29 (31%)
		AMN1	383..600	CDD:187754	66/277 (24%)
		leucine-rich repeat	431..456	CDD:275381	6/35 (17%)
		leucine-rich repeat	457..482	CDD:275381	7/38 (18%)
		leucine-rich repeat	483..508	CDD:275381	5/24 (21%)
		leucine-rich repeat	509..534	CDD:275381	8/26 (31%)
		leucine-rich repeat	535..560	CDD:275381	9/24 (38%)
		leucine-rich repeat	561..585	CDD:275381	10/23 (43%)
		leucine-rich repeat	586..610	CDD:275381	7/74 (9%)
		leucine-rich repeat	636..661	CDD:275381	4/21 (19%)
FBXL13	NP_001381423.1	Sfi1	<112..>224	CDD:400658
		F-box-like	245..289	CDD:403981	10/41 (24%)
		leucine-rich repeat	285..312	CDD:275381	5/26 (19%)
		AMN1	312..497	CDD:187754	36/186 (19%)
		leucine-rich repeat	313..336	CDD:275381	5/22 (23%)
		leucine-rich repeat	337..362	CDD:275381	3/24 (13%)
		leucine-rich repeat	363..387	CDD:275381	2/23 (9%)
		leucine-rich repeat	388..406	CDD:275381	7/17 (41%)
		leucine-rich repeat	416..441	CDD:275381	7/26 (27%)
		leucine-rich repeat	442..491	CDD:275381	8/48 (17%)
		leucine-rich repeat	468..490	CDD:275381	2/21 (10%)
		leucine-rich repeat	492..515	CDD:275381	6/23 (26%)
		leucine-rich repeat	518..542	CDD:275381	5/24 (21%)
		AMN1	529..737	CDD:187754	51/208 (25%)
		leucine-rich repeat	543..570	CDD:275381	8/26 (31%)
		leucine-rich repeat	571..596	CDD:275381	9/24 (38%)
		leucine-rich repeat	597..645	CDD:275381	13/47 (28%)
		leucine-rich repeat	646..671	CDD:275381	5/24 (21%)
		leucine-rich repeat	672..697	CDD:275381	0/24 (0%)
		leucine-rich repeat	698..723	CDD:275381	10/24 (42%)
		leucine-rich repeat	724..749	CDD:275381	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820