DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and AMN1

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001106873.1	Gene:	AMN1 / 196394	HGNCID:	27281	Length:	258	Species:	Homo sapiens

Alignment Length:	340	Identity:	73/340 - (21%)
Similarity:	132/340 - (38%)	Gaps:	102/340 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 PYERRI--LAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGKLYNSLIRRGFHALGLV 361
            |..||:  |..:|: | ..:....||.:.:.|         :|...:.:|...:..:|
Human     2 PRPRRVSQLLDLCL-W-CFMKNISRYLTDIKP---------LPPNIKDRLIKIMSMQG------- 48

  Fly   362 GASDEDALDVVHSFPLASKHVHSLSLRCSSISDRGLETLLDHLQSLFELELAGCNEVTEAGLWAC 426
            ..:|.:..:::|      ..|.:|.||...|||..|            |.|:.|.::.:..|
Human    49 QITDSNISEILH------PEVQTLDLRSCDISDAAL------------LHLSNCRKLKKLNL--- 92

  Fly   427 LTPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQSHSLSILRLQSC 491
                  :.|..:.:::..|.:.|||.....|:|.|                          |:.|
Human    93 ------NASKGNRVSVTSEGIKAVASSCSYLHEAS--------------------------LKRC 125

  Fly   492 WELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDGVELIAENLQKLRALDLSWCPRITDASLEYIA- 555
            ..||:.|:|.:..:...|.::.|.||..:||..:..:.:|...|:.:|.| ..:::|:.:..:.
Human   126 CNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFS-ATQVSDSGVIALVS 189

  Fly   556 --CDLNQLEELTLDRCVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHLCSMRNLQVLSLAG 618
              | ..:|||:.:..||::||   |.:..:|:       :|.|:|              :|...|
Human   190 GPC-AKKLEEIHMGHCVNLTD---GAVEAVLT-------YCPQIR--------------ILLFHG 229

  Fly   619 CPLLTSSGLSSLIQL 633
            |||:|......|.||
Human   230 CPLITDHSREVLEQL 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	8/23 (35%)
		AMN1	383..600	CDD:187754	49/219 (22%)
		leucine-rich repeat	431..456	CDD:275381	5/24 (21%)
		leucine-rich repeat	457..482	CDD:275381	3/24 (13%)
		leucine-rich repeat	483..508	CDD:275381	6/24 (25%)
		leucine-rich repeat	509..534	CDD:275381	7/24 (29%)
		leucine-rich repeat	535..560	CDD:275381	5/27 (19%)
		leucine-rich repeat	561..585	CDD:275381	8/23 (35%)
		leucine-rich repeat	586..610	CDD:275381	3/23 (13%)
		leucine-rich repeat	636..661	CDD:275381
AMN1	NP_001106873.1	AMN1	37..257	CDD:187754	63/294 (21%)
		leucine-rich repeat	63..86	CDD:275381	11/34 (32%)
		leucine-rich repeat	87..116	CDD:275381	6/37 (16%)
		leucine-rich repeat	117..142	CDD:275381	9/50 (18%)
		leucine-rich repeat	143..168	CDD:275381	7/24 (29%)
		leucine-rich repeat	169..195	CDD:275381	5/27 (19%)
		leucine-rich repeat	196..221	CDD:275381	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810