DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and fbxl13

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_002933148.2	Gene:	fbxl13 / 100496930	XenbaseID:	XB-GENE-6042355	Length:	808	Species:	Xenopus tropicalis

Alignment Length:	605	Identity:	120/605 - (19%)
Similarity:	232/605 - (38%)	Gaps:	169/605 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 QHMQLQQSQQQHLQLQASTLINSNHHVMVGPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNP 215
            ::..::::::|.|.|:..  :..|||...                .::||.:|.:.
Frog   118 EYCSMRKARKQELNLKLQ--VADNHHAHT----------------LLRSIVRQWDY--------- 155

  Fly   216 GSPTFSTMGMVAAQKAAASAGGTPLQ-------LRKQLPNPHLH-------------------HP 254
                     .|..:|...|...|.::       ::|.|...|..                   ..
Frog   156 ---------WVKYRKQQQSVAATKIKKVFNDAFMKKILKAWHAETQDSKKKREYFERLERGDMDD 211

  Fly   255 YGSMGINAASPLIMQHQLHPPPIHSIEQLMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRS 319
            ||:..   :|||.....       ::.|  |..:.:.:.|.:....:....||||..|: .:.::
Frog   212 YGNFN---SSPLREGED-------NVSQ--LPPKAVLKIFSFVDLIDLARSAQVCRSWK-IISQN 263

  Fly   320 PRYWSGL-------------------------------------LPTL----QCRELRQMPGCDR 343
            ...||.:                                     .||.    :|:.|:.:...:.
Frog   264 SSLWSSIDFSSVRQYVQDKFVVNTLRKCRLYVIRLNFRSCSSLHWPTFKAIGECKNLQDLNLSEC 328

  Fly   344 GKLYNSLIR---RGFHALGLVGASDEDALDVVHSFPLASK---HVHSLSLR-CSSISDRGLETLL 401
            ..|.:..||   .|..||..:..|..|..:.  :..:.|:   ::..|||. |...:|:||:
Frog   329 IHLNDESIRIICEGCPALLYLNISHTDVTNA--TLRIVSRCLLNLQFLSLAYCRKFTDKGLQ--- 388

  Fly   402 DHLQS------LFELELAGCNEVTEAG--LWACLTPRIVSLSLADCINIADEAVGAVAQLLPSLY 458
             :|.|      |..|:|:||.:::..|  ..|.....:..|.:.|...:.|:.:.|:.:...::.
Frog   389 -YLGSGKGCPKLIYLDLSGCTQISVDGFTFLAAGCNSLQQLKINDMFTLTDKCITALLEKCQNIL 452

  Fly   459 EFS-LQAYHVTDAALGYFSPKQSHSLSILRLQSCWELTNHGI-------VNIVH----------- 504
            ..| |.:.|::|.|....:  |...|:.:|::....:|:..|       .|:.|
Frog   453 SISLLGSPHLSDVAFKVLA--QGRKLAKIRIEGNNRITDSSIKAICKFCANLNHIYVADCQKITD 515

  Fly   505 -------SLPHLTVLSLSGCSKLTDDGVELIAENLQ--KLRALDLSWCPRITDASLEYIACDLNQ 560
                   .|.::|:|:::.|.:::|.||..:.|...  |:|.|:|:.|.|::|.||..||...:.
Frog   516 VSLKAISVLKNITILNVADCIRISDPGVRQVLEGPSGTKIRELNLTNCIRVSDLSLLRIAQKCHN 580

  Fly   561 LEELTLDRCVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHLCSMRNLQVLSLAGCPLLTSS 625
            |..|:|..|.::||.|...:..|.||.::.|.. :.:.|.||..|.:...::.||::.|..::..
Frog   581 LTYLSLRYCENLTDSGFELLGNMASLISIDLSG-TNITDQGLSALGAHSTIKELSVSECFGISDI 644

  Fly   626 GLSSLI-QLRHLQELELTNC 644
            |:.... |.|.|::|:|::|
Frog   645 GIQKFCQQSRDLEQLDLSHC 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	8/24 (33%)
		AMN1	383..600	CDD:187754	62/253 (25%)
		leucine-rich repeat	431..456	CDD:275381	4/24 (17%)
		leucine-rich repeat	457..482	CDD:275381	6/25 (24%)
		leucine-rich repeat	483..508	CDD:275381	7/49 (14%)
		leucine-rich repeat	509..534	CDD:275381	7/26 (27%)
		leucine-rich repeat	535..560	CDD:275381	10/24 (42%)
		leucine-rich repeat	561..585	CDD:275381	8/23 (35%)
		leucine-rich repeat	586..610	CDD:275381	6/23 (26%)
		leucine-rich repeat	636..661	CDD:275381	4/9 (44%)
fbxl13	XP_002933148.2	Sfi1	<103..>206	CDD:369887	16/123 (13%)
		F-box-like	227..271	CDD:372399	10/46 (22%)
		leucine-rich repeat	242..266	CDD:275381	5/24 (21%)
		leucine-rich repeat	267..287	CDD:275381	2/19 (11%)
		leucine-rich repeat	295..308	CDD:275381	0/12 (0%)
		AMN1	318..580	CDD:187754	61/269 (23%)
		leucine-rich repeat	320..345	CDD:275381	5/24 (21%)
		leucine-rich repeat	346..370	CDD:275381	4/25 (16%)
		leucine-rich repeat	371..391	CDD:275381	7/23 (30%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	4/24 (17%)
		leucine-rich repeat	451..475	CDD:275381	6/25 (24%)
		leucine-rich repeat	476..501	CDD:275381	4/24 (17%)
		leucine-rich repeat	502..520	CDD:275381	1/17 (6%)
		leucine-rich repeat	527..554	CDD:275381	7/26 (27%)
		AMN1	538..697	CDD:187754	40/128 (31%)
		leucine-rich repeat	555..580	CDD:275381	10/24 (42%)
		leucine-rich repeat	581..605	CDD:275381	8/23 (35%)
		leucine-rich repeat	606..626	CDD:275381	6/20 (30%)
		leucine-rich repeat	630..655	CDD:275381	5/24 (21%)
		AMN1	656..>753	CDD:187754	4/9 (44%)
		leucine-rich repeat	656..681	CDD:275381	4/9 (44%)
		leucine-rich repeat	682..707	CDD:275381
		leucine-rich repeat	708..733	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010