DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_038962809.1	Gene:	Fbxl13 / 100125363	RGDID:	1642425	Length:	823	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	108/532 - (20%)
Similarity:	191/532 - (35%)	Gaps:	194/532 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 MLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGL-------------LPTLQ---- 331
            :|.|:.:.:.|.|.:..:....:||...|...:.|. ..|:.:             :.|||
  Rat   244 VLPDQAVVQIFVYLTFKDLVSCSQVNRSWMSMIQRG-SLWNSIDFSTVKNIADRCVVTTLQKWRL 307

  Fly   332 ----------------------CRELRQM-----------------PGCDRGKLYNS-------- 349
                                  |:.|:::                 .||. |.||.:
  Rat   308 NVLRLNFRGCVLRAKTLKSVSHCKNLQELNVSDCPSFTDESMRHISEGCP-GVLYLNLSNTTITN 371

  Fly   350 ----LIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLR-CSSISDRGLE--TLLDHLQSL 407
                |:.|.||                        ::.:|||. |...:|:||:  .|.:....|
  Rat   372 RTMRLLPRYFH------------------------NLQNLSLAYCRKFTDKGLQYLNLGNGCHKL 412

  Fly   408 FELELAGCNEVTEAGLW----ACLTPRIVSLSLADCINIADEAVGAVAQLLPSLYE-FSLQAYHV 467
            ..|:|:||.:::..|..    :|  ..|:.|::.|...:.|..|..:.:..|.:.. ..:.:.|:
  Rat   413 IYLDLSGCTQISVQGFRNIANSC--TGIMHLTINDMPTLTDNCVKVLVEKCPRISSVVFIGSPHI 475

  Fly   468 TDAALGYFS---------------------------PKQSH---------------SLSILRLQS 490
            :|.|....|                           |..||               |||:|:..:
  Rat   476 SDCAFKALSACDLKKIRFEGNKRITDACFKSVDRNYPGISHIYMVDCKGLTDSSLKSLSVLKQLT 540

  Fly   491 CWELTN-------------HGIVNIVHSLPHLTVLSLSGCSKLTDDGVELIAENLQKLRALDLSW 542
            ...|||             .|..::     .|..|:|:.||.|.|..|..::|....|..|:|..
  Rat   541 VLNLTNCVRIGDIGLRQFFDGPASV-----KLRELNLANCSLLGDTSVIRLSERCPNLHYLNLRN 600

  Fly   543 CPRITDASLEYIACDLN-----------------------QLEELTLDRCVHITDIGV-GYISTM 583
            |..:||.::||||..|:                       :|.|::|..||:|||.|: .:..|.
  Rat   601 CEHLTDLAIEYIASMLSLISIDLSGTLISNEGLAILSRHRKLREVSLSECVNITDFGIRAFCKTS 665

  Fly   584 LSLTALFLRWCSQVRDFGLQHL---CSMRNLQVLSLAGCPLLTSSGLSSL-IQLRHLQELELTNC 644
            |:|..|.:.:|:|:.|..::.:   |:  .:..|.:||||.:|..|:..| .:..:|..|:::.|
  Rat   666 LALEHLDVSYCAQLTDDIIKTIAIFCT--RITSLHIAGCPKITDGGMEILSARCHYLHILDISGC 728

  Fly   645 PGASHELFDYLK 656
            ...:.::...|:
  Rat   729 VQLTDQILQDLQ 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	8/26 (31%)
		AMN1	383..600	CDD:187754	71/303 (23%)
		leucine-rich repeat	431..456	CDD:275381	5/24 (21%)
		leucine-rich repeat	457..482	CDD:275381	7/67 (10%)
		leucine-rich repeat	483..508	CDD:275381	7/37 (19%)
		leucine-rich repeat	509..534	CDD:275381	9/24 (38%)
		leucine-rich repeat	535..560	CDD:275381	11/47 (23%)
		leucine-rich repeat	561..585	CDD:275381	10/24 (42%)
		leucine-rich repeat	586..610	CDD:275381	6/26 (23%)
		leucine-rich repeat	636..661	CDD:275381	4/21 (19%)
Fbxl13	XP_038962809.1	Sfi1	<134..>214	CDD:400658
		F-box-like	242..286	CDD:403981	9/42 (21%)
		leucine-rich repeat	257..270	CDD:275381	2/12 (17%)
		leucine-rich repeat	282..308	CDD:275381	4/25 (16%)
		AMN1	308..477	CDD:187754	33/195 (17%)
		leucine-rich repeat	309..332	CDD:275381	1/22 (5%)
		leucine-rich repeat	333..358	CDD:275381	3/25 (12%)
		leucine-rich repeat	359..383	CDD:275381	6/47 (13%)
		leucine-rich repeat	384..402	CDD:275381	7/17 (41%)
		leucine-rich repeat	412..437	CDD:275381	7/26 (27%)
		leucine-rich repeat	438..463	CDD:275381	5/24 (21%)
		leucine-rich repeat	464..486	CDD:275381	4/21 (19%)
		leucine-rich repeat	488..513	CDD:275381	0/24 (0%)
		leucine-rich repeat	514..534	CDD:275381	3/19 (16%)
		AMN1	525..733	CDD:187754	56/214 (26%)
		leucine-rich repeat	539..563	CDD:275381	4/23 (17%)
		leucine-rich repeat	567..592	CDD:275381	9/24 (38%)
		leucine-rich repeat	593..617	CDD:275381	10/23 (43%)
		leucine-rich repeat	618..641	CDD:275381	0/22 (0%)
		leucine-rich repeat	642..667	CDD:275381	10/24 (42%)
		leucine-rich repeat	668..693	CDD:275381	6/26 (23%)
		leucine-rich repeat	694..719	CDD:275381	8/24 (33%)
		leucine-rich repeat	720..745	CDD:275381	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820