DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32085 and zgc:158376

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001093617.1	Gene:	zgc:158376 / 100101643	ZFINID:	ZDB-GENE-070720-8	Length:	818	Species:	Danio rerio

Alignment Length:	776	Identity:	169/776 - (21%)
Similarity:	256/776 - (32%)	Gaps:	286/776 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KRINGLGLRSKH---------------HHSSTSSGAG-GAGDAASPAGATPTPAAPSGKTSVMER 67
            |:|.  |.|.||               :..::|||.| |:|.||:.|..:.:....|.:...:||
Zfish   194 KKIK--GAREKHLKKKVKPNSSDSSEANGPNSSSGGGHGSGTAAASALLSASQDQRSHQREKLER 256

  Fly    68 VTNALC-------GGGNSNSNSGSNSSNSNTSSASATAATSPASNA------------------- 106
            . ..:|       ...:|:|:|..:.|.|::.|.|..||:.|:|.|
Zfish   257 F-KRMCQLLERVRDSSSSSSSSSESDSESDSDSPSPIAASEPSSPAYGGSARERNRRLAELGFSA 320

  Fly   107 -----------------NPPQ----------------TPDK-----------PSRGSSPSPGGIT 127
                             ..||                .|::           |:..:||.|...|
Zfish   321 SEESEGESVAEVEVEGVEEPQRRRGDGARVRRAALEPEPEEEEEGVGDHRAAPAAPASPQPNTQT 385

  Fly   128 MP------------------GGQSQVQNSTHHLLQQQQQQQQHMQLQQSQQQHLQLQASTLINSN 174
            .|                  .||......|....:||:::..|              :|...|..
Zfish   386 PPFTHTHSTGTDGLPSSKRTNGQDARNGRTRVGREQQEKENAH--------------SSAAPNHR 436

  Fly   175 HHVMVGPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQKAAASAGGTP 239
            |   |.||..:.|..|.....:..| .|..:..:..|..| ||..|:....:|....|:.....|
Zfish   437 H---VKPARGSKMRGGGRQGQSAAS-GKSSSAAVSSGTAN-GSTGFTNPAPLAGASLASHRSQQP 496

  Fly   240 --------LQLRKQLPNPHLHHPYGSMGINAASPLIMQ-HQLHPPPI----HSIEQLMLD----- 286
                    |..|..:|.|           :...||.|: |.:.|||.    |.   |.||
Zfish   497 RVVPPRSQLVKRSSVPVP-----------SPPRPLQMERHLVRPPPACPEPHC---LPLDSGATH 547

  Fly   287 ----DRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGK-- 345
                |.:| |.||:.:..:..:..:||..|        ..|        |.:.|.....|..:
Zfish   548 VLPRDVWL-RVFQHLNQRQLCVCMRVCRTW--------SRW--------CCDKRLWTRIDLSRQR 595

  Fly   346 -----LYNSLIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLRCSSISDRGLETLLDHLQ 405
                 :.:|:|||.                     |:|      |:|..::||.:.|..|::.||
Zfish   596 SITPPMLSSIIRRQ---------------------PVA------LNLGFTNISKKQLMWLINRLQ 633

  Fly   406 SLFELELAGCNEVTEAGLWACLTPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDA 470
            .|.||.|:||:       |:.::  .:..|:..|:.:.|  :..|..|
Zfish   634 GLLELNLSGCS-------WSSVS--ALCQSVCPCLRLLD--LSRVEDL----------------- 670

  Fly   471 ALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDGV-ELIAENLQK 534
                   |.||...:|...|....:.|| .|......::|.|.|||..  ..||| .|:...|..
Zfish   671 -------KDSHLKELLAPPSNDTRSAHG-ENRGGRFQNVTELRLSGLE--VSDGVSRLLVRYLPH 725

  Fly   535 LRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYISTMLSLTALFLRWCSQVRD 599
            |..||||.|.:|||.::..:...|:.|.|                     |||.:.|..|::|.|
Zfish   726 LTKLDLSQCSQITDQTIHTLTSALSPLRE---------------------SLTHINLAGCAKVTD 769

  Fly   600 FGLQHLCSMRNLQVLSLAGCPLLTSSGLSSLIQLRHLQELELTNCPGASHELFDYLKEHLP 660
            ..:..|....:||.|.|..|.||....            .:|.:.|.|..:| :.|:.|.|
Zfish   770 QCVPLLRRCASLQTLDLRSCLLLAPDA------------SQLHSFPAAPEQL-NTLQTHTP 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	7/23 (30%)
		AMN1	383..600	CDD:187754	56/217 (26%)
		leucine-rich repeat	431..456	CDD:275381	5/24 (21%)
		leucine-rich repeat	457..482	CDD:275381	2/24 (8%)
		leucine-rich repeat	483..508	CDD:275381	5/24 (21%)
		leucine-rich repeat	509..534	CDD:275381	10/25 (40%)
		leucine-rich repeat	535..560	CDD:275381	10/24 (42%)
		leucine-rich repeat	561..585	CDD:275381	2/23 (9%)
		leucine-rich repeat	586..610	CDD:275381	7/23 (30%)
		leucine-rich repeat	636..661	CDD:275381	7/25 (28%)
zgc:158376	NP_001093617.1	zf-CXXC	<21..55	CDD:251032
		PHD_FXL19	65..126	CDD:277115
		F-box-like	549..592	CDD:289689	12/59 (20%)
		leucine-rich repeat	559..583	CDD:275381	6/39 (15%)
		leucine-rich repeat	586..610	CDD:275381	5/44 (11%)
		AMN1	591..792	CDD:187754	69/286 (24%)
		leucine-rich repeat	611..633	CDD:275381	7/27 (26%)
		leucine-rich repeat	635..658	CDD:275381	8/31 (26%)
		leucine-rich repeat	659..700	CDD:275381	11/67 (16%)
		leucine-rich repeat	701..725	CDD:275381	10/25 (40%)
		leucine-rich repeat	726..755	CDD:275381	12/49 (24%)
		leucine-rich repeat	756..780	CDD:275381	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910