DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7339 and RPC25

DIOPT Version :9

Sequence 1:	NP_001261720.1	Gene:	CG7339 / 39310	FlyBaseID:	FBgn0036188	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_012778.1	Gene:	RPC25 / 853713	SGDID:	S000001627	Length:	212	Species:	Saccharomyces cerevisiae

Alignment Length:	216	Identity:	84/216 - (38%)
Similarity:	133/216 - (61%)	Gaps:	7/216 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLAELKDNVRIAPDQFHLKLVDAVRDEIDRKLANKVLLNVGLCIALKDIVSLKDSIILPGDGA 65
            ||:|:::.|.|||.|||||...:.|:..:::.|.|||::.||||||.:.|::::::..:.||||:
Yeast     1 MFILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPNVGLCITIYDLLTVEEGQLKPGDGS 65

  Fly    66 SHTEVLFRYVVFRPMVGTVITGKIRNCSREGVHVT-LGFFDDILIPHAALQHPSRFDEAEQAWVW 129
            |:..|.||.|||:|.:|.::||.|..|:.||:.|: ||.||||.||...|.....:...|.||:|
Yeast    66 SYINVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCYYTPEESAWIW 130

  Fly   130 EYPLEDGAKHDLFMDVGEPIKFRVSREIFEETSPIGPPKTEAQTQ-QGASTSAAVASATSQEVKT 193
              |:::..|  |:.||.|.|:||:.||:|.:..|..|.:.|.:.: |..:........|.|..|.
Yeast   131 --PMDEETK--LYFDVNEKIRFRIEREVFVDVKPKSPKERELEERAQLENEIEGKNEETPQNEKP 191

  Fly   194 P-YRIIGAINESGLGVLSWWD 213
            | |.::|:....|:|::|||:
Yeast   192 PAYALLGSCQTDGMGLVSWWE 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7339	NP_001261720.1	RPB7	1..212	CDD:224020	82/213 (38%)
		RNAP_III_Rpc25_N	2..81	CDD:239822	35/78 (45%)
		RNA_pol_Rbc25	79..212	CDD:285491	47/135 (35%)
RPC25	NP_012778.1	rpoE	1..184	CDD:129540	73/186 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343695
Domainoid	1	1.000	91	1.000	Domainoid score	I1763
eggNOG	1	0.900	-	-		E1_COG1095
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6337
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1015
Isobase	1	0.950	-	0	Normalized mean entropy	S661
OMA	1	1.010	-	-		QHG54252
OrthoFinder	1	1.000	-	-		FOG0004963
OrthoInspector	1	1.000	-	-		oto99059
orthoMCL	1	0.900	-	-		OOG6_101831
Panther	1	1.100	-	-	LDO	PTHR12709
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1195
SonicParanoid	1	1.000	-	-		X3501
TreeFam	1	0.960	-	-
	16	15.740