DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7339 and POLR3H

DIOPT Version :9

Sequence 1:	NP_001261720.1	Gene:	CG7339 / 39310	FlyBaseID:	FBgn0036188	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001018060.1	Gene:	POLR3H / 171568	HGNCID:	30349	Length:	204	Species:	Homo sapiens

Alignment Length:	215	Identity:	120/215 - (55%)
Similarity:	155/215 - (72%)	Gaps:	17/215 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLAELKDNVRIAPDQFHLKLVDAVRDEIDRKLANKVLLNVGLCIALKDIVSLKDSIILPGDGA 65
            ||||.|:.|.|||.|.||..||.|::.:|:::||||||:.||||||.|.||..|:|:.:.|||||
Human     1 MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGA 65

  Fly    66 SHTEVLFRYVVFRPMVGTVITGKIRNCSREGVHVTLGFFDDILIPHAALQHPSRFDEAEQAWVWE 130
            |||:|.||.|||.|.:..::.|||:.||.|||||:||||||||||..:||.|::||||||.||||
Human    66 SHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWE 130

  Fly   131 YPLEDGAKHDLFMDVGEPIKFRVSREIFEETSPIGPPKTEAQTQQGASTSAAVASATSQEV---K 192
            |..|:|| |||:||.||.|:|||..|.|.:|||.||             |:|.|:.:|:|:   :
Human   131 YETEEGA-HDLYMDTGEEIRFRVVDESFVDTSPTGP-------------SSADATTSSEELPKKE 181

  Fly   193 TPYRIIGAINESGLGVLSWW 212
            .||.::|:|:|.|||:||||
Human   182 APYTLVGSISEPGLGLLSWW 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7339	NP_001261720.1	RPB7	1..212	CDD:224020	118/213 (55%)
		RNAP_III_Rpc25_N	2..81	CDD:239822	47/78 (60%)
		RNA_pol_Rbc25	79..212	CDD:285491	71/135 (53%)
POLR3H	NP_001018060.1	RNAP_III_Rpc25_N	2..81	CDD:239822	47/78 (60%)
		RNA_pol_Rbc25	83..201	CDD:400543	70/131 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..179		10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146937
Domainoid	1	1.000	148	1.000	Domainoid score	I4506
eggNOG	1	0.900	-	-		E1_COG1095
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6337
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3353
Isobase	1	0.950	-	0	Normalized mean entropy	S661
OMA	1	1.010	-	-		QHG54252
OrthoDB	1	1.010	-	-		D1430056at2759
OrthoFinder	1	1.000	-	-		FOG0004963
OrthoInspector	1	1.000	-	-		oto88597
orthoMCL	1	0.900	-	-		OOG6_101831
Panther	1	1.100	-	-	LDO	PTHR12709
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1195
SonicParanoid	1	1.000	-	-		X3501
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750