Protein Alignment RIOK1 and RIOK3

DIOPT Version :10

• Sequence 1: NP_648489.1
• Gene: RIOK1 / 39309
• FlyBaseID: FBgn0036187
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_003822.2
• Gene: RIOK3 / 8780
• HGNCID: 11451
• Length: 519
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 159/462 - (34%)
• Similarity: 249/462 - (53%)
• Gaps: 82/462 - (17%)

  Fly    10 DAEEDEEDLRSSEWTNDFKNLTLKHEIFKDIKLTPKEDCDDLAQVIATANEEDEPEDEEPEEYDE 74
            |.|.|.:..|..:..|....:::..|.::  |:.|.||.|                    ...||
Human    89 DREYDAQLRREEKKFNGDSKVSISFENYR--KVHPYEDSD--------------------SSEDE 131

  Fly    75 DDYDDIGDDYDTYEEAYTGFNKLHVQPQLTNASGGGSGGGAGGASGGSQRVSSYQPNEKLLRRYS 139
            .|:.|..|  |.|..|         :|..|...         |..|..:.:::........|:.:
Human   132 VDWQDTRD--DPYRPA---------KPVPTPKK---------GFIGKGKDITTKHDEVVCGRKNT 176

  Fly   140 ARINVEKYDPT------TNMSAQAANRLVN-------FDRRDRTQVRDKHDRATAEQVMDPRTRM 191
            ||  :|.:.|.      ..|..:.:|.:.|       .:.|...::.:|.:.:|||:.:||:||:
Human   177 AR--MENFAPEFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRL 239

  Fly   192 ILFKLLNRGMIQEINGCISTGKEANVYHAVSKNGEE----------EFAIKIYKTSILVFKDRDK 246
            :::|::|.||::.|.||||||||:.|:||...:.|:          |.|||::||::..||:|||
Human   240 LMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDK 304

  Fly   247 YVSGEFRFRHGYCKHNPRKMVRTWAEKEMRNYLRMRNAGVPVPEPILLRSHVLVMRFCGRDGWPA 311
            |:..:|||:..:.|.||||::|.||||||.|..||:.||:|.|..:||:.|:|||.|.|.|..||
Human   305 YIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPA 369

  Fly   312 PKLKDVELSTSKARELYRDCVVIMWRIYNQCRLVHADLSEFNILLQDGQLVIIDVSQSVEHDHPH 376
            ||||:|:|::.:.:|.|...:.:|.::|::|.||||||||:|:|...|::.:||||||||..|||
Human   370 PKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPH 434

  Fly   377 SFDFLRKDCTNISEFFRKRAV-ATMTVKELFDFITDQTITTENMEECLERISERIKDRDFDA-IS 439
            ..:||.:||.|:|:||:|..| ..::.:|||:.::...||.:|             :.||.| |.
Human   435 GLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADN-------------EADFLAEIE 486

  Fly   440 AQEKIDE 446
            |.||::|
Human   487 ALEKMNE 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIOK1	NP_648489.1	RIO1_euk	205..395	CDD:270698	99/199 (50%)
RIOK3	NP_003822.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..159		16/77 (21%)
		RIO3_euk	253..453	CDD:270697	99/199 (50%)