DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIOK1 and RIO1

DIOPT Version :9

Sequence 1:	NP_648489.1	Gene:	RIOK1 / 39309	FlyBaseID:	FBgn0036187	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_014762.3	Gene:	RIO1 / 854286	SGDID:	S000005645	Length:	484	Species:	Saccharomyces cerevisiae

Alignment Length:	519	Identity:	188/519 - (36%)
Similarity:	276/519 - (53%)	Gaps:	98/519 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ASGGSQRVSSYQPNEKLLRRYSARINVEKYDPTTNMSAQAANRLVNFDRRDRTQVRDKHDRATAE 182
            :.|.|..:     |.:||.:||.:|..::               ::|.|...:  :||.:|||.|
Yeast    13 SQGASDHI-----NNQLLEKYSHKIKTDE---------------LSFSRAKTS--KDKANRATVE 55

  Fly   183 QVMDPRTRMILFKLLNRGMIQEINGCISTGKEANVYHAVSKNG------EE-------------- 227
            .|:||||...|..::.||:|.::|||:|||||||||||.:..|      ||
Yeast    56 NVLDPRTMRFLKSMVTRGVIADLNGCLSTGKEANVYHAFAGTGKAPVIDEETGQYEVLETDGSRA 120

  Fly   228 EFAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKHNPRKMVRTWAEKEMRNYLRMRNAGV-PVPEP 291
            |:|||||||||||||||::||.||||||:...:||||||::.|||||.||..|:..:|| |.|:|
Yeast   121 EYAIKIYKTSILVFKDRERYVDGEFRFRNSRSQHNPRKMIKIWAEKEFRNLKRIYQSGVIPAPKP 185

  Fly   292 ILLRSHVLVMRFCGR-DGWPAPKLKDVELSTSKARE----LYRDCVVIMWRIYNQCRLVHADLSE 351
            |.::::||||.|..| :|:.:|||||...   |.|:    .|...|..|..:|..||||||||||
Yeast   186 IEVKNNVLVMEFLSRGNGFASPKLKDYPY---KNRDEIFHYYHTMVAYMRLLYQVCRLVHADLSE 247

  Fly   352 FNILLQDGQLVIIDVSQSVEHDHPHSFDFLRKDCTNISEFFRKRAVATMTVKELFDFITDQTITT 416
            :|.::.|.:|.:||||||||.:||.|.||||.|..|::.:|.|..::....:.:|.|:..:|:
Yeast   248 YNTIVHDDKLYMIDVSQSVEPEHPMSLDFLRMDIKNVNLYFEKMGISIFPERVIFQFVISETL-- 310

  Fly   417 ENMEECLERISERIKDRDFDAISA---------------QEKIDEAVWQNTYIPKRLD--EVRHF 464
                       |:.|. |::.|||               |::.::.::::.::.:.|.  |.|.|
Yeast   311 -----------EKFKG-DYNNISALVAYIASNLPIKSTEQDEAEDEIFRSLHLVRSLGGLEERDF 363

  Fly   465 ER------DVAKA--KQGVQQNLIYGKITGLTSDLDVQQKPDVLQSSTAKEDDGSEAQTSGSEDE 521
            :|      |:.|:  ....::|.      ..:...:.........|.|.:..|..|..:||||::
Yeast   364 DRYTDGKFDLLKSLIAHDNERNF------AASEQFEFDNADHECSSGTEEFSDDEEDGSSGSEED 422

  Fly   522 DNSQDNDNDEDAKKFKNSARPREESPESKKARKKAVKDAKAEQRKVKVKKHVKKRKEKMGSMKK 585
            |..:....|:|..|....  .:.|..:.||.||:..||||.|:||.|||||:||:..|....||
Yeast   423 DEEEGEYYDDDEPKVLKG--KKHEDKDLKKLRKQEAKDAKREKRKTKVKKHIKKKLVKKTKSKK 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIOK1	NP_648489.1	RIO1	164..420	CDD:224632	131/281 (47%)
RIOK1	NP_648489.1	RIO1_euk	205..395	CDD:270698	110/215 (51%)
RIO1	NP_014762.3	RIO1_euk	78..291	CDD:270698	110/215 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346164
Domainoid	1	1.000	181	1.000	Domainoid score	I701
eggNOG	1	0.900	-	-		E1_COG1718
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6950
Inparanoid	1	1.050	290	1.000	Inparanoid score	I531
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54258
OrthoFinder	1	1.000	-	-		FOG0003427
OrthoInspector	1	1.000	-	-		oto100173
orthoMCL	1	0.900	-	-		OOG6_101068
Panther	1	1.100	-	-	LDO	PTHR45723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1102
SonicParanoid	1	1.000	-	-		X2320
TreeFam	0	0.000	Not matched by this tool.
	14	13.830