DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIOK1 and RIOK1

DIOPT Version :9

Sequence 1:	NP_648489.1	Gene:	RIOK1 / 39309	FlyBaseID:	FBgn0036187	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_011513235.2	Gene:	RIOK1 / 83732	HGNCID:	18656	Length:	580	Species:	Homo sapiens

Alignment Length:	594	Identity:	290/594 - (48%)
Similarity:	382/594 - (64%)	Gaps:	56/594 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EEDLRSSEWTNDFKNLTLKHEIFKDIKLTPKED---CDDLAQVIATANEEDEPEDEEPEEYDEDD 76
            :::.::.|  :.||.:.|.....:|:|...::|   .:|| |.....|.|.|.||||.|.||:||
Human    18 QQNWKTGE--HGFKEMELIGSENRDLKTVKEKDDILFEDL-QDNVNENGEGEIEDEEEEGYDDDD 79

  Fly    77 YDDIGDDYDTYEEAYTGFNKLHVQPQLTNASG----GGSGGGAGGASGGSQRVSSYQPNEKLLRR 137
                 ||:|..|    |..||        |.|    |||...|...:..|.......|.:|:||:
Human    80 -----DDWDWDE----GVGKL--------AKGYVWNGGSNPQANRQTSDSSSAKMSTPADKVLRK 127

  Fly   138 YSARINVEKYDPTTNMSAQAANRLVNFDRR---DRTQVRDKHDRATAEQVMDPRTRMILFKLLNR 199
            :..:||::|    .|::....|::....|:   |..:::||.||||.|||:||||||||||:|.|
Human   128 FENKINLDK----LNVTDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTR 188

  Fly   200 GMIQEINGCISTGKEANVYHAVSKNGEEEFAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKHNPR 264
            |:|.|||||||||||||||||.:.|||.. |||||||||||||||||||||||||||||||.|||
Human   189 GIITEINGCISTGKEANVYHASTANGESR-AIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPR 252

  Fly   265 KMVRTWAEKEMRNYLRMRNAGVPVPEPILLRSHVLVMRFCGRDGWPAPKLKDVELSTSKARELYR 329
            |||:|||||||||.:|:..|.:|.||||:||||||||.|.|:|..|||.||:|:||.|||||||.
Human   253 KMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYL 317

  Fly   330 DCVVIMWRIYNQCRLVHADLSEFNILLQDGQLVIIDVSQSVEHDHPHSFDFLRKDCTNISEFFRK 394
            ..:..|.|:|...|||||||||||:|...|.:.||||||||||||||:.:||||||.|:::||.:
Human   318 QVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMR 382

  Fly   395 RAVATMTVKELFDFITDQTITTENMEECLERISERIKDRDFDAISAQEKIDEAVWQNTYIPKRLD 459
            .:||.|||:|||:|:||.:||.|||:..|.:..|....|..:..|:|:.:||.|::..|||:.|:
Human   383 HSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYIPRTLN 447

  Fly   460 EVRHFERD---VAKAKQ------GVQQNLIYGKITGLTSDLD-VQQKPDVLQSSTAKEDDGSEAQ 514
            ||:::|||   :.|.|:      ..|.|::|..:|||..||. ||:.|.:|      |:...|..
Human   448 EVKNYERDMDIIMKLKEEDMAMNAQQDNILYQTVTGLKKDLSGVQKVPALL------ENQVEERT 506

  Fly   515 TSGSEDEDNSQDNDNDEDAKKFKNSARPREESPE---SKKARKKAVKDAKAEQRKVKVKKHVKKR 576
            .|.|||..:|:.:|.|.:.:  .:.|||::.:.:   .||.|||.||:|:.|:||.|:.||||||
Human   507 CSDSEDIGSSECSDTDSEEQ--GDHARPKKHTTDPDIDKKERKKMVKEAQREKRKNKIPKHVKKR 569

  Fly   577 KEKMGSMKK 585
            |||....||
Human   570 KEKTAKTKK 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIOK1	NP_648489.1	RIO1	164..420	CDD:224632	178/258 (69%)
RIOK1	NP_648489.1	RIO1_euk	205..395	CDD:270698	137/189 (72%)
RIOK1	XP_011513235.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158946
Domainoid	1	1.000	273	1.000	Domainoid score	I1797
eggNOG	1	0.900	-	-		E1_COG1718
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6950
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1392
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54258
OrthoDB	1	1.010	-	-		D1238900at2759
OrthoFinder	1	1.000	-	-		FOG0003427
OrthoInspector	1	1.000	-	-		oto91309
orthoMCL	1	0.900	-	-		OOG6_101068
Panther	1	1.100	-	-	LDO	PTHR45723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1102
SonicParanoid	1	1.000	-	-		X2320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800