DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIOK1 and riok-1

DIOPT Version :9

Sequence 1:	NP_648489.1	Gene:	RIOK1 / 39309	FlyBaseID:	FBgn0036187	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001021570.2	Gene:	riok-1 / 171883	WormBaseID:	WBGene00019698	Length:	506	Species:	Caenorhabditis elegans

Alignment Length:	572	Identity:	241/572 - (42%)
Similarity:	334/572 - (58%)	Gaps:	98/572 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NLTLKHEIFKDIKL-TPKEDCDDLAQVIATANEEDEPEDEEPEEYDED-DYDDIGDDYDTYEEAY 91
            ||.::: |.:|:.: |.....||..:......|:.|..::..|:||.| |||   ||...:.||.
Worm     8 NLNIQN-ILEDVDIDTASSSSDDEPEQAVVKQEKLEAGEQIEEQYDTDSDYD---DDIVEFAEAT 68

  Fly    92 TGFNKLHVQPQLTNASGGGSGGGAGGASGGSQRVSSYQPNEKLLRRYSARINVEKYDPTTNMSAQ 156
            ..|.|      ..||:                |:::..||   ..|....::||::..|:
Worm    69 GDFTK------KLNAA----------------RLNTIGPN---AARNRLTVDVERHADTS----- 103

  Fly   157 AANRLVNFDRRDRTQVRDKHDRATAEQVMDPRTRMILFKLLNRGMIQEINGCISTGKEANVYHAV 221
                    :.|.|.:|:|:.||||.|||:|||||::||:||.||.:..|:||||||||||||||.
Worm   104 --------EDRKRKRVKDRADRATVEQVLDPRTRLVLFRLLQRGTLLNIDGCISTGKEANVYHAT 160

  Fly   222 SKNGEEEFAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKHNPRKMVRTWAEKEMRNYLRMRNAGV 286
            ..  :.:.||||||||||.||||::||:||||:||||||.||||||..||||||||..||...|:
Worm   161 GT--DNDLAIKIYKTSILTFKDRERYVTGEFRYRHGYCKSNPRKMVAVWAEKEMRNLARMHEVGL 223

  Fly   287 PVPEPILLRSHVLVMRFCGRDGWPAPKLKDVELSTSKARELYRDCVVIMWRIYNQCRLVHADLSE 351
            |||:|.||:.|||||.|.|:||||||.||:..||...|..:|...|..|.|:|.:|:||||||||
Worm   224 PVPKPHLLKGHVLVMDFLGKDGWPAPLLKNANLSQEDAEPMYVGLVRDMRRLYRECKLVHADLSE 288

  Fly   352 FNILLQDGQLVIIDVSQSVEHDHPHSFDFLRKDCTNISEFFRKRAVATMTVKELFDFITDQTITT 416
            ||:|:.||:|.|||||||||.||||:.:|||.||.|:::|||:..|..::|:.||:.|.|..:::
Worm   289 FNMLVHDGKLWIIDVSQSVEQDHPHALEFLRMDCNNVNKFFRELGVPVLSVRRLFEVIVDPLMSS 353

  Fly   417 ENMEECLERISERIKDRDFDAISAQEKIDEAVWQNTYIPKRLDEVRHFERDVAKAKQGVQQNLIY 481
            :.||..:|  .||:      .::::   |::::.|.:||.:|:.|.|||||...||:||:.|
Worm   354 KEMETIIE--EERV------LVNSE---DDSLFMNAFIPHKLEHVLHFERDGKLAKEGVEAN--- 404

  Fly   482 GKITGLTSDLDVQQKPDVLQSSTAKEDDGSEAQTSGSEDEDNSQDNDNDEDAKKF-KNSARP--- 542
            .....:.|.:|:             :.||.      .|:.|:|.|||::|:.||. |..|.|
Worm   405 NPFQNIVSKIDL-------------KGDGF------GEEHDDSDDNDDEENGKKSRKKRAEPTEE 450

  Fly   543 ---------------REESPESKKARKKAVKDAKAEQRKVKVKKHVKKRKEK 579
                           |||:.|.:|.||.|||:.|.||||.|:.||:|||..:
Worm   451 EIQEKERKIAMHTRNREETAEERKERKAAVKEEKREQRKEKIPKHLKKRAHR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIOK1	NP_648489.1	RIO1	164..420	CDD:224632	152/255 (60%)
RIOK1	NP_648489.1	RIO1_euk	205..395	CDD:270698	124/189 (66%)
riok-1	NP_001021570.2	RIO1	98..334	CDD:224632	147/250 (59%)
riok-1	NP_001021570.2	RIO1_euk	144..330	CDD:270698	122/187 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166474
Domainoid	1	1.000	247	1.000	Domainoid score	I1184
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6950
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1084
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54258
OrthoDB	1	1.010	-	-		D1238900at2759
OrthoFinder	1	1.000	-	-		FOG0003427
OrthoInspector	1	1.000	-	-		oto18182
orthoMCL	1	0.900	-	-		OOG6_101068
Panther	1	1.100	-	-	LDO	PTHR45723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910