DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and NPEPPS

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens

Alignment Length:	967	Identity:	214/967 - (22%)
Similarity:	382/967 - (39%)	Gaps:	198/967 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            |.|:.|:|.:...|    ....|||.:....:..|.|..|.:|..:|.|.   |..|......:|
Human    58 VSPINYSLCLKPDL----LDFTFEGKLEAAAQVRQATNQIVMNCADIDII---TASYAPEGDEEI 115

  Fly    87 GALQIKRIIKKTSLIKIVIELP--LRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVFYSA- 148
            .|....   .:....|:.:..|  |::| ..||.:.|.|.|:...:..|.:.|...:..|.|:|
Human   116 HATGFN---YQNEDEKVTLSFPSTLQTG-TGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAV 176

  Fly   149 TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPL 213
            |:.|...|...|||:|:|..:..::|:||..:..||||||..::.|||.:.||.|...|..:|.:
Human   177 TQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVM 241

  Fly   214 ATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLF--AYPLPKG 276
            :|..|.:.:.:.:.|.: .:..|..:.|::....||:.....|:.......|:..|  .||||
Human   242 STYLVAFVVGEYDFVET-RSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLP-- 303

  Fly   277 ADWGGKVDHVVLPRYTE-MYSGQGIMVYGED--IVDSGQNGLESLQETLAELV----ARQWNGLL 334
                 |:|.:.:..:.. .....|::.|.|.  ::|. :|...|.::.:|.:|    |.||.|.|
Human   304 -----KIDLIAIADFAAGAMENWGLVTYRETALLIDP-KNSCSSSRQWVALVVGHELAHQWFGNL 362

  Fly   335 VNLEDSDEEYVRNGI--------------NYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAK 385
            |.:|.....::..|.              .|.:..|.::.|          .||...|  |:|..
Human   363 VTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSAD----------YTRAQEL--DALDN 415

  Fly   386 VKSIATDVKESGH--------QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKE 442
            ...|...|   ||        ..:...|...:|.||...:|||.|.||:..:..::...:|::::
Human   416 SHPIEVSV---GHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATED 477

  Fly   443 LWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAK--QIVTITQSRYYQ--KYLD 503
            |||..:..        :|..:..||.:|.||.||||:.|:.:..:  :::.::|.::..  .|:
Human   478 LWESLENA--------SGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYV- 533

  Fly   504 NSSNDC--WWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYD 566
              ..||  |.||:.  :.....|....|....:..::..:.....|:.|:.:|:......|..|.
Human   534 --GEDCPQWMVPIT--ISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYS 594

  Fly   567 SYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALL 631
            |..|:.:...:|.  ..:|.:.|:.|.:|..||:.:|.:.....|.|:....||.:..||.....
Human   595 SAMLESLLPGIRD--LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSC 657

  Fly   632 NLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTES 696
            ||..|.:::..|.    |...:|:.::..|                      ||: .|..|....
Human   658 NLGILSTLLSHTD----FYEEIQEFVKDVF----------------------SPI-GERLGWDPK 695

  Fly   697 PDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLAC----QFEIKE 757
            |                                        .:..|.|:|..|..    :...|.
Human   696 P----------------------------------------GEGHLDALLRGLVLGKLGKAGHKA 720

  Fly   758 CLTDAQQRFQAAMDQKS--SSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLN 820
            .|.:|::||:..::.|.  |:.:...:...||..|....|:   ||:: :..:::..:|::.:..
Human   721 TLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLD---IMLK-LHKQADMQEEKNRIER 781

  Fly   821 SLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVL-RSPLGYYVGKQFLIDHSKEI------- 877
            .|..|.....:||:|::||..:..|:. |.|::..|. .|..|.....:|:.|:.:|:
Human   782 VLGATLLPDLIQKVLTFALSEEVRPQD-TVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGG 845

  Fly   878 -LRSKDVKL-ILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNW 932
             |.|:.:|: .|||.|                    |:...:.:..:.|.|..|::|
Human   846 FLISRLIKVQWLTPVI--------------------PALWDAEVGRSPEVGSSRLSW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	120/485 (25%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	75/393 (19%)
NPEPPS	XP_016880861.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820