Protein Alignment CG6071 and AAP1

DIOPT Version :10

• Sequence 1: NP_648488.1
• Gene: CG6071 / 39308
• FlyBaseID: FBgn0036186
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 979
• Identity: 216/979 - (22%)
• Similarity: 385/979 - (39%)
• Gaps: 209/979 - (21%)

  Fly    13 LSAKLAESFVKPLRYNLTILTRLGSEDEQN----QFEGIVSIDIEATQPT-RVIYLNSLNITISR 72
            :|.::..:.|.||.|::|:        |.|    .|||.:.||::....: ..:.:|.|.|....
Yeast     1 MSREVLPNNVTPLHYDITL--------EPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHS 57

  Fly    73 QRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRS----GEIYTLNMLFSGNLDRSQQYGY 133
            .|.        ..:.|:::.   |..:..|..:..|..:    |....|.::|||.|:......|
Yeast    58 ARI--------EGVNAIEVN---KNENQQKATLVFPNGTFENLGPSAKLEIIFSGILNDQMAGFY 111

  Fly   134 FAGYYDK-TPRVFYSA-TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPY 196
            .|.|.|| |....|.| |::|...|...|||||:|..:..:.:|||.:.....|||| .|..:..
Yeast   112 RAKYTDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNM-DVRNETI 175

  Fly   197 KEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSG----PAAAGENITVWSRP----------HL 247
            ||.:.|  |||..:|.::|..|.:.:..|..|.|.    |      :.|:|.|          :|
Yeast   176 KEGKKY--TTFNTTPKMSTYLVAFIVADLRYVESNNFRIP------VRVYSTPGDEKFGQFAANL 232

  Fly   248 AEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGE-----D 306
            |.:..:..|.|.|:        .||||       |:|.|.:..::. .....|::.|..     |
Yeast   233 AARTLRFFEDTFNI--------EYPLP-------KMDMVAVHEFSAGAMENWGLVTYRVIDLLLD 282

  Fly   307 IVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDK--------E 363
            |.:|..:.::.:.|.:...:|.||.|.||.::..:..::..|...::|  ..:.:|        |
Yeast   283 IENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMS--WYSCNKFQPEWKVWE 345

  Fly   364 AYNTTHLSKTRLDVLYHDSLAKVKSIATDVKESGH-----QKLRKKKMCLLIHMLKVALGDKLFL 423
            .|.|.:|.:    .|..|||.....|...|..:..     ..:...|...|:.|:...||::.|:
Yeast   346 QYVTDNLQR----ALNLDSLRSSHPIEVPVNNADEINQIFDAISYSKGSSLLRMISKWLGEETFI 406

  Fly   424 KGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQ 488
            ||:.::..::...:|.:.:||:.....        :|..:.:||..|.|:.|||:|:|:  :.|.
Yeast   407 KGVSQYLNKFKYGNAKTGDLWDALADA--------SGKDVCSVMNIWTKRVGFPVLSVK--EHKN 461

  Fly   489 IVTITQSRYYQKYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLI 553
            .:|:||.||..........|....|:...:::.|......:..:|::  ..||.:    |::..|
Yeast   462 KITLTQHRYLSTGDVKEEEDTTIYPILLALKDSTGIDNTLVLNEKSA--TFELKN----EEFFKI 520

  Fly   554 NVDAAVPLRVFYDSYNLQLISEALRQ-DFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYL 617
            |.|.:   .:|..||:.:..::..:| :...:.:  |:.||.||.:||.||.......||:||..
Yeast   521 NGDQS---GIFITSYSDERWAKLSKQANLLSVED--RVGLVADAKALSASGYTSTTNFLNLISNW 580

  Fly   618 SNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINT 682
            .||.|.:|||..:.:|..|:|..       :|:  .:.::....|.||:.:..|.   ||:..|.
Yeast   581 KNEDSFVVWEQIINSLSALKSTW-------VFE--PEDILNALDKFTLDLVLNKL---SELGWNI 633

  Fly   683 KSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILY 747
                                                             ..|.:.:...|...|:
Yeast   634 -------------------------------------------------GEDDSFAIQRLKVTLF 649

  Fly   748 RLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESEND 812
            ..||....::..:.|.:.|:...: .:..:||...:.:|.....|.|.|.::..:.:::....:.
Yeast   650 SAACTSGNEKMQSIAVEMFEEYAN-GNKQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSS 713

  Fly   813 KERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEI 877
            :|:.|.|.:|....:...:::.||:.||             ..||..  .:|:..|.:..|.|.|
Yeast   714 EEKIIALRALGRFEDKELLERTLSYLLD-------------GTVLNQ--DFYIPMQGIRVHKKGI 763

  Fly   878 LR---------SKDVKLIL--TPFINAMSTK-----AEFSALNDHLHRNLPSSMVSGLSSTLESG 926
            .|         .:..|.:.  :|.:..:.|.     ..|.|| :.:.......:..|...||...
Yeast   764 ERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEAL-EKISAFYSRKVTKGFDQTLAQA 827

  Fly   927 LDRV 930
            ||.:
Yeast   828 LDTI 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..472	CDD:472708	117/490 (24%)
		ERAP1_C	550..930	CDD:463368	77/396 (19%)
		SSP160	691..>749	CDD:115579	3/57 (5%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	117/490 (24%)
		ERAP1_C	517..833	CDD:463368	77/398 (19%)