DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and TMA108

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	1008	Identity:	194/1008 - (19%)
Similarity:	361/1008 - (35%)	Gaps:	280/1008 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIGAL 89
            |::|....|....||...||: :.|.|:........|.....::.||:.        :|:.:.
Yeast    40 LKFNPNSTTLASIEDSFTQFK-LHSKDLIVLSAHATIGSTKFDLKISQD--------TGKHLS-- 93

  Fly    90 QIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNL-----DRSQQYGYF-AGYYDK---TPRVF 145
                |....|.|::..:.||      .|::.:.|.:     ...:.:|.| ..:.|:   |....
Yeast    94 ----IFNSESPIQLSNDCPL------ILSVQYVGKIRDIKTHHDKTFGIFKTNFMDRKTGTANNH 148

  Fly   146 YSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVE-----EKPYKEIENYVST 205
            ..||..:|..|..:|||.|:|..::.:.:.:..|.:|.|:|| .|||     :...|.:..:..|
Yeast   149 VVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSN-TPVEMVEALDSSQKHLVKFAKT 212

  Fly   206 TFMGSPPLATQQVM-WTLHQLEKVYSGPAAAGEN---ITV---WSRPHLAEKLAKVPEMTPNLFS 263
                  ||.|..|. :::..||.:.:.....|:.   :::   |...:.|..|..|.:..|.|.|
Yeast   213 ------PLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIYAPWDIANAAFTLDTVQKYLPLLES 271

  Fly   264 KYETLFAYPLPKGADWGGKVDHVVLPRYTEM-YSGQGIMVYGEDIVDSGQNGL------ESLQET 321
            .::.  .||||       |:|.|:||..::| ....|::....:.:....|.|      |..|:.
Yeast   272 YFKC--PYPLP-------KLDFVLLPYLSDMAMENFGMITIQLNHLLIPPNALANETVREQAQQL 327

  Fly   322 LAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAM--DKEAYNTT--HLSKTRLDVLYHDS 382
            :...:..||.|..::.:..:..:.......:|:..::..  |...|.|:  :|.:.....:..|
Yeast   328 IVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWTSEPYLLQQVEPTMCRD- 391

  Fly   383 LAKVKSIATDVKESGHQKLRKK------------------KMCLLIHMLKVALGDKLFLKGLQEF 429
                   |.||......::.::                  |..:::..|::|.|:....|||:..
Yeast   392 -------AADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLESV 449

  Fly   430 F---KRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPL--LTVQRDDAKQI 489
            |   |.:...|....::|....:..:..       ::...:.||.:.||.|:  :.|:..|.|..
Yeast   450 FEDTKTFHARSVKPMDIWNHIGKFLKSQ-------NITNFVSSWTRTPGLPVVKVEVEEKDGKTQ 507

  Fly   490 VTITQSRYYQKYLDNSSND-----CWWVPVAYIV-------RNLTLPQVEWLGCQKNSRDILELS 542
            ..:||.|:..: |.....|     .:.||:..::       :|:.|..    ...|....||.::
Yeast   508 TKLTQHRFINQ-LSTEEKDQLEDVPYQVPLFGVLPDGKMDTKNVLLTD----RTLKFDYPILVIN 567

  Fly   543 HIA---------NPEDWLLINVDAAVPLRVFYDSYNLQLISEA-LRQDFTQIPELSRIQLVDDAL 597
            |:|         :.|.:.|||           |....:.:||. ||:.|..:.:....:...:::
Yeast   568 HLAQGYYRVSYESEECYALIN-----------DKITEETLSEIDLRKIFLDLSQFIGDEGFQNSI 621

  Fly   598 SLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMT-TGFRIFKLYMQKLIEPAF 661
            .|....::     ||.|:..|.:.:...|:.....||.||:|.|.: |..::.....:|::.|.|
Yeast   622 HLHGLFKI-----LNHIASPSTKIASKYWDPLSKGLEVLQTIDRASLTSSKLQSFLKKKIVIPLF 681

  Fly   662 KTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTES 726
                                                                  |..:.|.  ..
Yeast   682 ------------------------------------------------------NKIDWPH--GE 690

  Fly   727 SDTTESPDTTKSDLSLSAILY------RLA--CQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIR 783
            .|.:.:|...|   .:|.:|:      :.|  ||...|..|            |...||:|.|:.
Yeast   691 FDKSTNPHELK---VMSQVLFLNKNSAKCAELCQIYFKHLL------------QGPRSSVPLELV 740

  Fly   784 EIVL------------------------CRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSC 824
            ..:|                        |.||.|    |.|.:.|     :|..|.::|:.:.:.
Yeast   741 NSILVVVSQHCANIKQWKKIFDLVKRSSCTGITN----HVINMYD-----QNSSETAMLIQNGAI 796

  Fly   825 TTEYWAMQKLLSWALDSKKVPRTM---TASLLSAVLRSPL-GY-YVGKQFLIDHSK---EILRSK 881
            .:        |.:.|||..|.:|:   |:::.|..:...| |: |..|:.|..:.|   :::|..
Yeast   797 ES--------LGFCLDSDIVKKTLNFITSNIESEGMELALFGFNYNFKKRLNKNEKPQDQVVRET 853

  Fly   882 DVKLILTPFIN-AMSTKAEFSALNDHLHRNLPS 913
            ..:..:..|.. |.....:.:...||||:.|.|
Yeast   854 IWEWYMGNFDQWARKATRKGTTTGDHLHKALRS 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	99/504 (20%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/406 (19%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	194/1008 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910