DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and APE2

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_012765.3	Gene:	APE2 / 853699	SGDID:	S000001640	Length:	952	Species:	Saccharomyces cerevisiae

Alignment Length:	978	Identity:	217/978 - (22%)
Similarity:	380/978 - (38%)	Gaps:	223/978 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPT-RVIYLNSLNITISRQRTWIYRWASGRK 85
            |.||.|:||:    ..:.:..:|||.|.|:::...|. ..:.||:::..|           ...|
Yeast   106 VVPLHYDLTV----EPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDI-----------HSAK 155

  Fly    86 IGALQIKRIIKKTSLIKIVIELPLRS-----GEIYTLNMLFSGNLDRSQQYGYFAGYYDK-TPRV 144
            ||.:....||.:..........|..:     |..: |::.|:|.|:.:....|.|.|.|| |...
Yeast   156 IGDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAF-LDIKFTGILNDNMAGFYRAKYEDKLTGET 219

  Fly   145 FYSA-TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEE--KPYKEIENYVSTT 206
            .|.| |::||..|...|||||:|..:..:.||||.|.....||||....|  |..|::     |.
Yeast   220 KYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKDGKKV-----TL 279

  Fly   207 FMGSPPLATQQVMWTLHQLEKVYSGPAAAGEN----ITVWSRPHLAEKLAKVPEMTPNLFSKYET 267
            |..:|.::|..|.:.:.:|:.|.|      :|    :.|::.|...:......::|....:.:|.
Yeast   280 FNTTPKMSTYLVAFIVAELKYVES------KNFRIPVRVYATPGNEKHGQFAADLTAKTLAFFEK 338

  Fly   268 LFA--YPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYG--EDIVDSGQNGLESLQETLAELV- 326
            .|.  ||||       |:|:|.:..::. .....|::.|.  :.::|...:.|:.:|. :||:|
Yeast   339 TFGIQYPLP-------KMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQR-VAEVVQ 395

  Fly   327 ---ARQWNGLLVNLEDSDEEYVRNG----INYYLSVQVMAMDK--EAYNTTHLSKTRLDVLYH-- 380
               |.||.|.||.::..:..::..|    :::|...:.....|  |.|.|        |.|.|
Yeast   396 HELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVT--------DTLQHAL 452

  Fly   381 --DSLAKVKSIATDVKESGH-----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSA 438
              |||.....|...||::..     ..:...|...|:.|:...||::.|:||:.::..::...:|
Yeast   453 SLDSLRSSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNA 517

  Fly   439 SSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLD 503
            .:::||:.....        :|..:.:||..|.|:.|||:::|. :|....:|..|:||......
Yeast   518 KTEDLWDALADA--------SGKDVRSVMNIWTKKVGFPVISVS-EDGNGKITFRQNRYLSTADV 573

  Fly   504 NSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRD----ILELSHIANPEDWLLINVDAAVPLRVF 564
            ....|....||...::.            ||..|    :.|.|.....||.....|::. ...::
Yeast   574 KPDEDKTIYPVFLALKT------------KNGVDSSVVLSERSKTIELEDPTFFKVNSE-QSGIY 625

  Fly   565 YDSYNLQLISEALRQ-DFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWET 628
            ..||..:..::..:| |...:.:  |:.||.|..:||.||.......||::|..:||.|.:||:.
Yeast   626 ITSYTDERWAKLGQQADLLSVED--RVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQ 688

  Fly   629 ALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGT 693
            .:.::..::|..               |.||  |.|.::|..          .||..:    ||.
Yeast   689 IINSISSMKSTW---------------LFEP--KETQDALDN----------FTKQLI----SGM 722

  Fly   694 TESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKEC 758
            |.....                       ..:|||:.       |...|...::..||.....:.
Yeast   723 THHLGW-----------------------EFKSSDSF-------STQRLKVTMFGAACAARDADV 757

  Fly   759 LTDAQQRFQAAMDQKSSS--SIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNS 821
            ...|.:.|   .|..|.:  :||..|:.||.....|.|...::..|..::.:..::.|:...|.|
Yeast   758 EKAALKMF---TDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPISNDEKLAALRS 819

  Fly   822 LSCTTEYWAMQKLLSWALDS------------------------------------KKVPRTMTA 850
            |....|...:::.|.:..|.                                    |::|..:
Yeast   820 LGRFKEPKLLERTLGYLFDGTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGL-- 882

  Fly   851 SLLSAVLRSPLGYYVGKQFLIDHSKEILRSKDVK---LILTPFINAMSTKAEF-----SALNDHL 907
            |:|.:|:......:...| .||..|:...:|..|   ..|...::.:::||::     ..:|.:|
Yeast   883 SMLGSVVTLGTSGFTSMQ-KIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWVNRDRDVVNKYL 946

  Fly   908 HRN 910
            ..|
Yeast   947 KEN 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	121/489 (25%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/407 (19%)
APE2	NP_012765.3	PepN	90..941	CDD:223385	214/968 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910