Protein Alignment CG6071 and AOPEP

DIOPT Version :9

• Sequence 1: NP_648488.1
• Gene: CG6071 / 39308
• FlyBaseID: FBgn0036186
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_001372995.1
• Gene: AOPEP / 84909
• HGNCID: 1361
• Length: 859
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 99/596 - (16%)
• Similarity: 192/596 - (32%)
• Gaps: 219/596 - (36%)

  Fly   159 VFPCFDDPRFRTPYNITLVHDRKYVAL----SNMPPVEEKPYKEIEN---YV-----STTFMGSP 211
            :|||.:.|...:.:..|:.....:|.|    ::..|.:  .::|..:   ||     ::||..:.
Human   281 LFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQ--LWEECSSWYYYVTMPMPASTFTIAV 343

  Fly   212 PLATQQVM--WTLHQL--EKVYSGPAAAGENITVWSR------------------PH-------- 246
            ...|:..|  |:.:.|  |:.:|...|...::.|.|.                  ||
Human   344 GCWTEMKMETWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCL 408

  Fly   247 ---LAEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTE---------MYSGQG 299
               ..|.|.::  :.|.|.:.:..|.|:|.       .::|.:::|....         |:..|.
Human   409 TGACQETLLRL--IPPCLSAAHSVLGAHPF-------SRLDVLIVPANFPSLGMASPHIMFLSQS 464

  Fly   300 IMVYGEDIVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYL----------- 353
            |:..|..:..:          .|...:|..|.||.:...|..||::..|...:|
Human   465 ILTGGNHLCGT----------RLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQL 519

  Fly   354 -----------------------------SVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSI 389
                                         .:||:...|:  .|.|.|.:...|:.|.
Human   520 APYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKD--KTGHTSDSGASVIKHG-------- 574

  Fly   390 ATDVKESGHQKLRKKKMCLLIHMLK---------VALGDKLFLKGLQEFFKRYANSSASSKELWE 445
                       |..:|:.:.:|.||         ..|||:.:...|::|...:......|::..:
Human   575 -----------LNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQ 628

  Fly   446 EFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCW 510
            ..........:|.  :|:..:.:.|::..|.| ..:||:                  ..:..:|.
Human   629 MLLENIPEEKRLE--LSVENIYQDWLESSGIP-KPLQRE------------------RRAGAECG 672

  Fly   511 WVPVAYIVRNLTLPQVEWLGCQKNSRD------------------ILELSHIANPE--------- 548
                  :.|.:.....:|:|..:..|.                  :|.|.|:...:
Human   673 ------LARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKLLPDQLVLLLEHLLEQKTLSPRTLQS 731

  Fly   549 ---DWLLINVDAAVPLR--------VFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWS 602
               .:.|.:.||.|..|        .|..:|  :.:...|::|..:..:.|.|:|:     |:|.
Human   732 LQRTYHLQDQDAEVRHRWCELIVKHKFTKAY--KSVERFLQEDQERPQQDSFIRLL-----LAWG 789

  Fly   603 GRLPYNVTLNV 613
            .||  .:||::
Human   790 TRL--ELTLDI 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	70/420 (17%)
		ERAP1_C	551..929	CDD:288671	18/71 (25%)
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:417498	68/414 (16%)
		Nucleolar localization signal. /evidence=ECO:0000250|UniProtKB:Q8BXQ6	689..699		1/9 (11%)
		Leuk-A4-hydro_C	721..>771	CDD:401171	8/51 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155424
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830