DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and APM1

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_195035.2	Gene:	APM1 / 829446	AraportID:	AT4G33090	Length:	879	Species:	Arabidopsis thaliana

Alignment Length:	994	Identity:	221/994 - (22%)
Similarity:	388/994 - (39%)	Gaps:	229/994 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRK 85
            |..|.||:|    ||..:.....|.|.|:||::....||.|.||:.:::::.........:|.:.
plant    13 FAVPKRYDL----RLNPDLIACTFTGTVAIDLDIVADTRFIVLNAADLSVNDASVSFTPPSSSKA 73

  Fly    86 IGALQIKRIIKKTSLIKIVIE----LPLRSGEIY-----TLNMLFSGNLDRSQQYGYFAGYYDKT 141
            :.|.::           ::.|    |.|..|||.     .|.:.|:|.|:...:..|.:.|....
plant    74 LAAPKV-----------VLFEEDEILVLEFGEILPHGVGVLKLGFNGVLNDKMKGFYRSTYEHNG 127

  Fly   142 PRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTT 206
            .:...:.|:.||..|...|||:|:|..:..:.|||......|||||||.:|||..   .|....:
plant   128 EKKNMAVTQFEPADARRCFPCWDEPACKATFKITLEVPTDLVALSNMPIMEEKVN---GNLKIVS 189

  Fly   207 FMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAE--KLA-KVPEMTPNLFSKYETL 268
            :..||.::|..|...:...:.| ....:.|..:.|:.:...|:  |.| .|...|.:||.:|
plant   190 YQESPIMSTYLVAIVVGLFDYV-EDHTSDGIKVRVYCQVGKADQGKFALHVGAKTLDLFKEY--- 250

  Fly   269 FA--YPLPKGADWGGKVDHVVLPRYT----EMYSGQGIMVYGE-----DIVDSGQNGLESLQETL 322
            ||  ||||       |:|.:.:|.:.    |.|   |::.|.|     |...|..:..:.:...:
plant   251 FAVPYPLP-------KMDMIAIPDFAAGAMENY---GLVTYRETALLYDEQHSAASNKQRVATVV 305

  Fly   323 AELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDK---EAYNTTHLSKTRLDVLYHDSLA 384
            |..:|.||.|.||.:|.....::..|...::|  .:|.|.   |....|.......:.|..|.|.
plant   306 AHELAHQWFGNLVTMEWWTHLWLNEGFATWVS--YLATDSLFPEWKIWTQFLDESTEGLRLDGLE 368

  Fly   385 KVKSIATDVKESGH-----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELW 444
            :...|..:|..:..     ..:..:|...:|.||:..||.::|.|.|..:.|.:|.|:|.:::||
plant   369 ESHPIEVEVNHAAEIDEIFDAISYRKGASVIRMLQSYLGAEVFQKSLAAYIKNHAYSNAKTEDLW 433

  Fly   445 EEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDC 509
            ...:.|        :|..:..:|.||.||.|:|:::.:..|.|  :.:.|||:...  .:.....
plant   434 AALEAG--------SGEPVNKLMSSWTKQKGYPVVSAKIKDGK--LELEQSRFLSS--GSPGEGQ 486

  Fly   510 WWVPVAYIVRNLTLPQVEWLGCQKNSRDILEL--SHIANPED-------WLLINVDAAVPLRVFY 565
            |.|||.....:....:...|..:..:.|:.||  ..||:..|       |:.||||.|...||.|
plant   487 WIVPVTLCCGSYEKRKNFLLESKSGAYDLKELLGCSIADGSDKINGTCSWIKINVDQAGFYRVKY 551

  Fly   566 DSYNLQLISEALRQ--DFTQIPELSRIQLVDDALSL----------------SWSGRLPYNVTLN 612
            |    ..::..||.  :...:..:.|..::||:.:|                ::...|.|.|..|
plant   552 D----DSLAAGLRNATESQSLTSIDRYGILDDSFALTMARQQSLASLLTLCSAYKKELDYTVLSN 612

  Fly   613 VISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSE 677
            :|:        :.::...:..:..|.:|   :|.:.|.:       ..|:.....|....:.|.
plant   613 LIA--------ISYKVVKIGADANQELM---SGIKHFFI-------GVFQFAAGKLGWDPKQGE- 658

  Fly   678 IPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSL 742
                                                                      :..|..|
plant   659 ----------------------------------------------------------SHLDAML 665

  Fly   743 SAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIRE----IVLCRGIRNGLEVHWIMVR 803
            ...:......|...|.|.:|.:||.|.:..:::..:|.:||.    .|:.|..::....:..::|
plant   666 RGEVLTALAVFGHDETLKEAVRRFDAFLADRNTPLLPPDIRRAAYVAVMQRANKSDKSGYESLLR 730

  Fly   804 DMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAV-----------L 857
             ::.|::..:|::.:|.||:...:...:|.:|::.| |.:|........||.|           |
plant   731 -VYRETDLSQEKTRILGSLASCPDPTIVQDVLNFVL-SDEVRNQDALYGLSGVSWEGREVAWKWL 793

  Fly   858 RSP---LGYYVGKQFLIDHSKEILRSKDVKLILTPFINAMSTK--AEFSALNDHLHRNLPSSMVS 917
            :..   :|...|..|||        ::.:..:::||.:....|  .||.|.     |:.||
plant   794 QEKWEYIGNTWGSGFLI--------TRFISAVVSPFASFEKAKEVEEFFAT-----RSKPS---- 841

  Fly   918 GLSSTLESGLDRV----NW 932
             ::.||:..::||    ||
plant   842 -MARTLKQSIERVHINANW 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	125/482 (26%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	72/415 (17%)
APM1	NP_195035.2	M1_APN-Q_like	18..453	CDD:341064	122/476 (26%)
APM1	NP_195035.2	ERAP1_C	536..855	CDD:403137	75/419 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920