DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Erap1

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_006231762.1	Gene:	Erap1 / 80897	RGDID:	708542	Length:	954	Species:	Rattus norvegicus

Alignment Length:	1039	Identity:	217/1039 - (20%)
Similarity:	410/1039 - (39%)	Gaps:	258/1039 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRK 85
            ::.|:.|:|.|...|.:    ..|.|...::|..:|||..|.::|..:.||:        |:.|:
  Rat    46 YITPIHYDLMIHANLST----LTFWGKTEVEITVSQPTSTIIMHSHQLQISK--------ATLRR 98

  Fly    86 IGALQIKRIIKKTSL----------IKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDK 140
             ||   :.::.:..|          :.::...||.:|.:||:.:.::.||..:     |.|:|..
  Rat    99 -GA---EEMLPEEPLKLMEYSAHEQVALLTAQPLLAGSVYTVIITYAANLSEN-----FHGFYKS 154

  Fly   141 TPRV------FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKE- 198
            |.|.      ..:||:.||..|...|||||:|..:..::|.:..|.:::|:||||.|:.....|
  Rat   155 TYRTQEGERRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVTVAEG 219

  Fly   199 -IENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLF 262
             ||::...|.    .::|..|.:.:...:.| |....:|..::|::.|....:.....:....|.
  Rat   220 LIEDHFDITV----KMSTYLVAFIISDFKSV-SKMTKSGVKVSVYAVPDKINQADYALDAAVTLL 279

  Fly   263 SKYETLFA--YPLPKGADWGGKVDHVVLPRYTEMYSGQ----GIMVYGED--IVDSGQNGLES-- 317
            ..||..|:  ||||       |.|...:|   :..||.    |:..|.|.  :.|..::...|
  Rat   280 EFYEDYFSIPYPLP-------KQDLAAIP---DFQSGAMENWGLTTYRESALLYDKEKSSASSKL 334

  Fly   318 -LQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLS-------------VQVM---------- 358
             :..|::..:|.||.|.||.:|..::.::..|...::.             :|::
  Rat   335 GITMTVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVMQILTANHQNEPED 399

  Fly   359 --------------------AMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDVKESGHQKLRK 403
                                ||:.:|.|::|...|.:     ::.|:::.:..:|.       .:
  Rat   400 LSGRAMERTEEEYFFGKCFNAMEVDALNSSHPVSTPV-----ENPAQIREMFDEVS-------YE 452

  Fly   404 KKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEF-------------------QR 449
            |..|:| :||:..|....|.:|:.::.::|:..:..:::||...                   |.
  Rat   453 KGACIL-NMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQH 516

  Fly   450 GARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQ---RDDAKQIVTITQSRYYQKYLDNSSNDC-- 509
            .:..||.....:.:.::|.:|..|.||||:|:.   |:     |.:.|..|.:      .::|
  Rat   517 SSSTSHWRQEVIDIKSMMNTWTLQKGFPLITITVRGRN-----VHLKQEHYMK------GSECFP 570

  Fly   510 -----WWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPE--DWLLINVDAAVPLRVFYDS 567
                 |.||:.:|.......|...|   |...|::.|     ||  :|:..||.......|.|..
  Rat   571 ETGSLWHVPLTFITSKSDSVQRFLL---KTKTDVIIL-----PEAVEWIKFNVGMNGYYIVHYGD 627

  Fly   568 YNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVL-VWE--TA 629
            .....::..|::..|.|....|..|:::|..|...|:|.....|::|.||.|||.:: :::  ..
  Rat   628 DGWASLNGLLKEAHTTISSNDRASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMPIFQGLNE 692

  Fly   630 LLNLEKL---QSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESS 691
            |:.:.||   :.::.:.|.|:.|.|.:.|.:                      || |...|.|.|
  Rat   693 LIPMYKLMEKRDMVEVETQFKDFLLRLLKDL----------------------IN-KQTWTDEGS 734

  Fly   692 GTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIK 756
                                                         .|:..|.:.|..|||....:
  Rat   735 ---------------------------------------------VSERMLRSQLLLLACVHRYQ 754

  Fly   757 ECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNS 821
            .|:..|::.|:.......:.|:|.::...|...|.:|  ...|..:...:..|.:..|:|.:..|
  Rat   755 LCVQRAERYFREWKASNGNMSLPIDVTLAVFAVGAQN--TEGWDFLYSKYQSSLSSTEKSQIEFS 817

  Fly   822 LSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEI-----LRSK 881
            |..:.:...:|.||..:...:.:.......:|:.:.|:|:||.:..:||.::..:|     |.|.
  Rat   818 LCISQDPEKLQWLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWNKIVQKFELGSS 882

  Fly   882 DVKLILTPFINAMSTKA---EFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLLK 942
            .:..::....|..||:|   |.......|.:|  .|.:..:..|:|:..:.:.|.:. .||.::
  Rat   883 SIAHMVMGTTNQFSTRARLEEVKGFFSSLKKN--GSQLRCVQQTIETIEENIRWMDK-NFDKIR 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	115/542 (21%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	77/391 (20%)
Erap1	XP_006231762.1	Peptidase_M1	42..454	CDD:279741	98/455 (22%)
		M1_APN_2	50..544	CDD:189008	115/542 (21%)
		ERAP1_C	611..927	CDD:288671	76/387 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850