DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and SON

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_620305.3	Gene:	SON / 6651	HGNCID:	11183	Length:	2426	Species:	Homo sapiens

Alignment Length:	453	Identity:	83/453 - (18%)
Similarity:	144/453 - (31%)	Gaps:	140/453 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 SIATD-------VKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWE 445
            |:.||       .|...|:|.:.||              |...|..::.:||....|.|..:..:
Human    94 SVQTDPTDEIPTKKSKKHKKHKNKK--------------KKKKKEKEKKYKRQPEESESKTKSHD 144

  Fly   446 E---------FQR-----------------GARRSHQLPTGVSLPTVMESWMKQP---------- 474
            :         |.:                 |...:::.|..|..|.|:...:.:|
Human   145 DGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPAT 209

  Fly   475 -----GFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKN 534
                 .....:|..:.::|.|.:.......|.||:.:  ...||...:|...:.|.|. :..:..
Human   210 KTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFA--AAPVPTTTLVLKSSEPVVT-MSVEYQ 271

  Fly   535 SRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQ--------IPELSRIQ 591
            .:.:|:.....:||...::.|:..| .:|...|..|.:.||...:.:.:        .||.|.|:
Human   272 MKSVLKSVESTSPEPSKIMLVEPPV-AKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIE 335

  Fly   592 LVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWE------TALLNLEK--LQSIMRM----TT 644
            .:          ||| ...::|.|.:::.:.....|      |..|.|::  :.|.|.:    .|
Human   336 AL----------RLP-EQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPPAT 389

  Fly   645 GFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPV----------TTESSGTTESP-- 697
            .       |.:|..|.....|......|....|:|....:||          ..|..|.:.:|
Human   390 S-------MPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSVTPVP 447

  Fly   698 --------------------DTTESPDTAES----PDTTESSNTTESPDTTESSDTTESPDTT 736
                                :..|.|..|:.    |..|.:....|.|..|.:.:.||.|.||
Human   448 QLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTT 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	21/136 (15%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	48/242 (20%)
SON	NP_620305.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..56
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..155		14/74 (19%)
		PHA03247	<170..460	CDD:223021	55/311 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328		3/22 (14%)
		PHA03379	<340..673	CDD:223066	35/179 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..442		7/35 (20%)
		17 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM	726..895
		MSCRAMM_SdrC	<730..903	CDD:380146
		11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]	912..988
		14 X 6 AA repeats of [ED]-R-S-M-M-S	1006..1126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1144..1236
		3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]	1147..1179
		rne	<1289..1481	CDD:236766
		4 X 8 AA tandem repeats of V-L-E-SS-[AVT]-VT	1359..1390
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1645..1722
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1754..2054
		7 X 7 AA repeats of P-S-R-R-S-R-[TS]	1925..1994
		2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S	1934..2013
		3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R	2013..2039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2200..2220
		G-patch	2305..2349	CDD:396249
		DSRM_SF	2369..>2419	CDD:412133
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910