Protein Alignment CG6071 and ERAP2

DIOPT Version :9

• Sequence 1: NP_648488.1
• Gene: CG6071 / 39308
• FlyBaseID: FBgn0036186
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_001123612.1
• Gene: ERAP2 / 64167
• HGNCID: 29499
• Length: 960
• Species: Homo sapiens
• Alignment Length: 1001
• Identity: 224/1001 - (22%)
• Similarity: 389/1001 - (38%)
• Gaps: 215/1001 - (21%)

  Fly    20 SFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGR 84
            |.|.||.|:|.:...|.|.|    |.....|::..:..|:.|.|:|.::.|:.
Human    71 SVVIPLHYDLFVHPNLTSLD----FVASEKIEVLVSNATQFIILHSKDLEITN------------ 119

  Fly    85 KIGALQIK---RIIKKTSLIKIVI-----ELPLRSGEIYTLNMLFSGNLDRSQQYG-YFAGYYDK 140
              ..||.:   |.:|....:|::.     ::.|...|..|.::.:...:|...:.| .|.|:|..
Human   120 --ATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKS 182

  Fly   141 TPRVFYSATRL------EPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVE--EKPYK 197
            |.|.....||:      ||..|...|||||:|.|:..::|.:..:.:::||||||.|:  |....
Human   183 TYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGG 247

  Fly   198 EIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLF 262
            .:|::..||...|..|.. .::...|.|    ||..::|..:::::.|....:.....:.:..|.
Human   248 LLEDHFETTVKMSTYLVA-YIVCDFHSL----SGFTSSGVKVSIYASPDKRNQTHYALQASLKLL 307

  Fly   263 SKYETLF--AYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGE-----DIVDSGQNGLESLQ 319
            ..||..|  .|||       .|:|.:.:|.:.. .....|::.|.|     |...|..:....:.
Human   308 DFYEKYFDIYYPL-------SKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVT 365

  Fly   320 ETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLS-VQVMAMDKEAYNTTHLSKTRLDVLYHDSL 383
            ..:|..:|.||.|.||.:|..::.:::.|...|:. :.|.|...|.....:......:|:..|||
Human   366 RVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSL 430

  Fly   384 AKVKSIA------TDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKE 442
            ...:.|:      |.::|...:....|..|:| :|||..||::.|.||:.::.|:::..:|.:.:
Human   431 NSSRPISKPAETPTQIQEMFDEVSYNKGACIL-NMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDD 494

  Fly   443 LWEEFQRGARRSHQLPTGV-------------------SLPTVMESWMKQPGFPLLTVQRDDAKQ 488
            ||.........|.....||                   .:..:|.:|..|.|.|||.|::|...
Human   495 LWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCS- 558

  Fly   489 IVTITQSRYYQ--------------KYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDIL 539
             :.:.|.|:.|              :||       |.:|:.|...:..:.....|   |:..|.|
Human   559 -LRLQQERFLQGVFQEDPEWRALQERYL-------WHIPLTYSTSSSNVIHRHIL---KSKTDTL 612

  Fly   540 ELSHIANPE--DWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWS 602
            :|     ||  .|:..|||:.....|.|:.:....:...|.|:.|.:....|:.|:.|...|..:
Human   613 DL-----PEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGA 672

  Fly   603 GRLPYNVTLNVISYLSNETSVLVWETALL-NLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLN 666
            |||..:..|::..||.:|||    ..||| .|..|:|...|          |.:
Human   673 GRLTLDKALDMTYYLQHETS----SPALLEGLSYLESFYHM----------MDR----------- 712

  Fly   667 SLSTKARTGSEIPINTK-------SPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTT 724
                  |..|:|..|.|       .||....|.:.:.
Human   713 ------RNISDISENLKRYLLQYFKPVIDRQSWSDKG---------------------------- 743

  Fly   725 ESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCR 789
                       :..|..|.:.|.:|||......|:..|.:.|...|:.....:||.::.:||...
Human   744 -----------SVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSV 797

  Fly   790 GIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLS 854
            |.:.  ...|..:.:.:..|.:..|::.:|.:||.:.....:.||:...::.|.:.....|:||.
Human   798 GAQT--TAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLH 860

  Fly   855 AVLRSPLGYYVGKQFLIDHSKEILR-----SKDVKLILTPFINAMSTKAEFSALNDHLHR----- 909
            |:.|.|.|..:...|:.::...:|:     |.|:::|::      .|.|.||: .|.|..
Human   861 AIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIIS------GTTAHFSS-KDKLQEVKLFF 918

  Fly   910 ---NLPSSMVSGLSSTLESGLDRVNW 932
               ....|.:....:.||:....:.|
Human   919 ESLEAQGSHLDIFQTVLETITKNIKW 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	117/502 (23%)
		ERAP1_C	551..929	CDD:288671	82/398 (21%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	98/416 (24%)
		M1_APN_2	76..548	CDD:189008	117/502 (23%)
		Substrate binding	334..338		0/3 (0%)
		ERAP1_C	621..938	CDD:288671	82/395 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155368
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850