Protein Alignment CG6071 and RNPEP

DIOPT Version :9

• Sequence 1: NP_648488.1
• Gene: CG6071 / 39308
• FlyBaseID: FBgn0036186
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_064601.3
• Gene: RNPEP / 6051
• HGNCID: 10078
• Length: 650
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 103/568 - (18%)
• Similarity: 194/568 - (34%)
• Gaps: 167/568 - (29%)

  Fly   160 FPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEK-PYKEIENYVSTTFMGSPPLATQQVMWTLH 223
            |||||.|..:..|:..:.....:.|:.:....|:: |.|..       |....|:.:..:...:.
Human   179 FPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKFF-------FQMCQPIPSYLIALAIG 236

  Fly   224 QLEKVYSGPAAAGENITVWSRPHL------------------AEKLAKVPEMTPNLFSKYETLFA 270
            .|.....||.:     .||:.|.|                  .|||     ..|.::.:|:.||
Human   237 DLVSAEVGPRS-----RVWAEPCLIDAAKEEYNGVIEEFLATGEKL-----FGPYVWGRYDLLF- 290

  Fly   271 YPLPKGADWGGKVDHVVLPRYTEMYSGQGIMVYGEDIVDSGQNGLESLQETLAELVARQWNGLLV 335
              :|....:|| :::..|...|.      .::.|:          .||.:.:...::..|.|.||
Human   291 --MPPSFPFGG-MENPCLTFVTP------CLLAGD----------RSLADVIIHEISHSWFGNLV 336

  Fly   336 NLEDSDEEYVRNGINYYLSVQVMAM-------DKEAYNTTHLSKTRLDVLYHDS-LAKVK---SI 389
            ...:..|.::..|...|...::..:       ..||.....|.:..:|:...:: |.|::   ..
Human   337 TNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEP 401

  Fly   390 ATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEF------- 447
            ..|..::.::...:|..|.:.::..: :||:   .....|.|.|.:.......|.::|
Human   402 GVDPDDTYNETPYEKGFCFVSYLAHL-VGDQ---DQFDSFLKAYVHEFKFRSILADDFLDFYLEY 462

  Fly   448 --QRGARRSHQLPTGVSLPTVMESWMKQPGFP---------------------LLTVQRDDAKQI 489
              :...:|...:| |..    .:.|:..||:|                     |...:..|.|.|
Human   463 FPELKKKRVDIIP-GFE----FDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAI 522

  Fly   490 --VTITQSRYYQ--KYLDNSSNDCWWVPVAYIVRNLTLP--QVEWLGCQKNSRDILELSHIANPE 548
              |.|:..:.||  .:||.            |::...||  .|:.||....|     :|:..|.|
Human   523 EAVAISPWKTYQLVYFLDK------------ILQKSPLPPGNVKKLGDTYPS-----ISNARNAE 570

  Fly   549 DWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTL-N 612
                        ||:.:...   ::....::||.::.|....|           |:..|.:.| :
Human   571 ------------LRLRWGQI---VLKNDHQEDFWKVKEFLHNQ-----------GKQKYTLPLYH 609

  Fly   613 VISYLSNETSVLVWETALLNLEKLQS-IMRMTTGFRIFKLYMQKLIEP 659
            .:...|.....|..||......:|.| ::.          |:|:::.|
Human   610 AMMGGSEVAQTLAKETFASTASQLHSNVVN----------YVQQIVAP 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	64/355 (18%)
		ERAP1_C	551..929	CDD:288671	18/111 (16%)
RNPEP	NP_064601.3	leuko_A4_hydro	24..634	CDD:274120	98/543 (18%)
		M1_LTA4H	24..484	CDD:189006	62/350 (18%)
		Substrate binding. /evidence=ECO:0000250	298..302		2/4 (50%)
		Leuk-A4-hydro_C	504..644	CDD:286244	37/192 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740