DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6071 and RNPEPL1

DIOPT Version :9

Sequence 1:NP_648488.1 Gene:CG6071 / 39308 FlyBaseID:FBgn0036186 Length:962 Species:Drosophila melanogaster
Sequence 2:NP_060696.4 Gene:RNPEPL1 / 57140 HGNCID:10079 Length:725 Species:Homo sapiens


Alignment Length:526 Identity:107/526 - (20%)
Similarity:173/526 - (32%) Gaps:151/526 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 HTV-----FPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQ 216
            |:|     |||||.|..:..|:..:   :....:..:.......|.|.|....  |....|:...
Human   198 HSVCNRSFFPCFDTPAVKCTYSAVV---KAPSGVQVLMSATRSAYMEEEGVFH--FHMEHPVPAY 257

  Fly   217 QVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNL-------FSKYETLFAYPLP 274
            .|......|:     ||..|....||:.|.|      :|..|..|       .|..|.|:     
Human   258 LVALVAGDLK-----PADIGPRSRVWAEPCL------LPTATSKLSGAVEQWLSAAERLY----- 306

  Fly   275 KGADWGGKVDHVVLPRYTEMYSGQG-IMVYGEDIVDSGQNGLESLQETLAELVARQWNGLLVNLE 338
             |....|:.|.|.||....:.:.:. .:.:   |:.|.....|.|...:...||..|.|..|...
Human   307 -GPYMWGRYDIVFLPPSFPIVAMENPCLTF---IISSILESDEFLVIDVIHEVAHSWFGNAVTNA 367

  Fly   339 DSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDVKESGHQ-KLR 402
            ..:|.::..|:..|...::......|..|...:..|||.|:.    ::|.:..|...|..| ||.
Human   368 TWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHR----QMKLLGEDSPVSKLQVKLE 428

  Fly   403 --------------KKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWE-------- 445
                          :|..|.:.::.::....:.|...|:.:.::|..:|..:::|.:        
Human   429 PGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPE 493

  Fly   446 ------------EFQRGARRS------HQLPTGVSLPTVMES----WMKQP-------------- 474
                        ||:|....:      ..|..|.||...:|:    |..:|              
Human   494 LKEQSVDCRAGLEFERWLNATGPPLAEPDLSQGSSLTRPVEALFQLWTAEPLDQAAASASAIDIS 558

  Fly   475 ----------------GFPLLTVQRDDAKQIVTITQSRYYQKYLD--NSSNDCWWVPVAYIVRNL 521
                            |.||        .|.|.::.|:.|...||  |:.....|:.:  :|||.
Human   559 KWRTFQTALFLDRLLDGSPL--------PQEVVMSLSKCYSSLLDSMNAEIRIRWLQI--VVRND 613

  Fly   522 TLPQVEWLGCQKNSRDILE-----LSHIANPEDWLLINVDAAVPLRVFYDSY-----NL-----Q 571
            ..|.:.      ..|..||     :..|...|| |......:..|.|||.:.     ||     |
Human   614 YYPDLH------RVRRFLESQMSRMYTIPLYED-LCTGALKSFALEVFYQTQGRLHPNLRRAIQQ 671

  Fly   572 LISEAL 577
            ::|:.|
Human   672 ILSQGL 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6071NP_648488.1 GluZincin 25..477 CDD:301352 77/407 (19%)
ERAP1_C 551..929 CDD:288671 10/37 (27%)
RNPEPL1NP_060696.4 M1_LTA4H 29..512 CDD:341062 69/342 (20%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P15144 326..330 0/3 (0%)
Leuk-A4-hydro_C 560..673 CDD:401171 29/129 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..699 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155453
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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