DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and AgaP_AGAP001881

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_001689317.2	Gene:	AgaP_AGAP001881 / 5667739	VectorBaseID:	AGAP001881	Length:	957	Species:	Anopheles gambiae

Alignment Length:	1008	Identity:	229/1008 - (22%)
Similarity:	410/1008 - (40%)	Gaps:	236/1008 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIGA 88
            |:.|:|.:.|.:  .:...||.|.|.:..|..:||..:.|::..:|:  ||.:::..|.|...||
Mosquito    72 PIHYHLALRTAI--HENSRQFSGTVKVLFEVLEPTTTVTLHNRRLTV--QRAFLHEEAVGGGAGA 132

  Fly    89 LQIKRIIKK----TSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY--DKTPRVFYS 147
             ||:::...    |..:.:.:...|.:|..|.|.:.|.|.|..:...|:||..|  :...|.:.:
Mosquito   133 -QIEQVAHSTDPDTEHLTLAVSQLLPAGSRYYLRVEFEGALQNNNNMGFFASSYLDNSGNRRYLA 196

  Fly   148 ATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIEN--YVSTTFMGS 210
            :::.||.:|.:.|||:|:|..:..:.:.|.|.::|.|::|| |:...|..:.:|  ||::.|..:
Mosquito   197 SSKFEPTHARSAFPCYDEPLLKATFELELTHYKEYNAVANM-PLAGTPTPDSDNADYVTSRFEVT 260

  Fly   211 PPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPK 275
            |.::|..:.:.      |........:..||::||::.|                ||  ||||..
Mosquito   261 PLMSTYLLAFA------VTDFTIRTADRQTVYARPNVFE----------------ET--AYPLEA 301

  Fly   276 G---------------ADWGGKVDHVVLP-RYTEMYSGQGIMVYGEDI------VDSGQNGLESL 318
            |               .|:..|:..:.:| |.|......|::.|||.:      :::.:| .:|:
Mosquito   302 GNRILDALSDYMDISYYDYMPKMTQIAIPDRGTGAMENWGLVAYGEPVLLFNPAINTYRN-RKSV 365

  Fly   319 QETLAELVARQWNGLLVNLEDSDEEYVRNGI----NYY--------------LSVQVM--AMDKE 363
            ...:|...|.||.|.||:....:..::..|.    .||              .:|:|:  |...:
Mosquito   366 TTIIAHEYAHQWFGNLVSPHWWEYIWLNEGFATLYEYYAAQLAYPEGEYWELFTVEVIHSAFGAD 430

  Fly   364 AYNTTH------LSKTRLDVLYHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLF 422
            |..|..      .:.:.:..|: |::|..||.:                  :::|.:..|||.::
Mosquito   431 ASETVRPMNWNAATPSEIAALF-DTVAYDKSGS------------------VLNMFRAVLGDPVW 476

  Fly   423 LKGLQEFFKRYANSSASSKELWEEFQRG--ARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRD- 484
            ..||:.:........|::..|:...|..  :.....||..|::..:|:||..:||||:|||.|.
Mosquito   477 RYGLKTYMTARQLDGATADHLYGGLQEALVSLAPTLLPATVTVRQLMDSWTSEPGFPVLTVYRTY 541

  Fly   485 DAKQIVTITQSRYY-QKYLDNSSNDCWWVPVAYIVRNLTLPQVE-------WLGCQKNSRDILEL 541
            ..:|...::|.|:. .|.|  .|...::||  |.......|..|       ||..:.:.
Mosquito   542 GERQEAILSQERFLSSKRL--PSGHVYYVP--YDFTGGHAPDFEPTPAGYGWLAAKADK------ 596

  Fly   542 SHIAN--PED-WLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSG 603
              ||.  |.| |::.|.......||.||::|.:|:.|||..|..||...:|.|||:||.:|:.:.
Mosquito   597 --IATGVPNDQWIIFNRQQNGYYRVNYDAHNWELLIEALHNDPAQIHHRNRAQLVNDAYNLARAE 659

  Fly   604 RLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKT-TLNS 667
            .|.:.|.|.::|||..||....|..|...|..|.:.:|.|..:..|::|...|:...:.| .::|
Mosquito   660 WLDFAVPLRLMSYLRKETQYAPWTAAGSALTYLYNKLRGTAHYAHFQVYANHLLIDIYPTLAIDS 724

  Fly   668 LSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTES 732
            ::.:
Mosquito   725 VAAQ------------------------------------------------------------- 728

  Fly   733 PDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEV 797
              .|...|.|...:...||:....:||...:|...||  .::.:.:..:|...|.|.|:.:..:.
Mosquito   729 --ETLLQLYLKQFITTWACRVGHGDCLAKTKQALAAA--YQARTPVHPDIATAVYCNGLVDASDE 789

  Fly   798 HWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDS----KKVPRTMTASLLSAVL- 857
            .::.|.:.|..|.|...|::|:::|:|:.:...::..|:.||.|    ..:..|....::|||.
Mosquito   790 IFVWVYEQFKSSRNQAHRTVLIDALACSRQPAQLESFLTTALGSGAEFDALLATERTRIVSAVYG 854

  Fly   858 RSPLGYYVGKQFLIDHSKEILRSKDVKLILTPFINAMSTKAEFSALND----------------- 905
            .|..|......||:..|:           :|.|:..:...|..||:::
Mosquito   855 ASREGVDAVLDFLMVPSR-----------VTEFVQRLGQSALNSAVSNIASRTNNQPELDRLNAL 908

  Fly   906 --HLHRNLPSSMVSGLSSTLESGLDRVNWRNNL 936
              .|...:|.|:.:...||:::..   ||.|.|
Mosquito   909 LVSLGSQIPESVATSARSTVQNNF---NWFNTL 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	116/509 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	84/402 (21%)
AgaP_AGAP001881	XP_001689317.2	Peptidase_M1	65..460	CDD:279741	98/419 (23%)
		M1_APN_2	73..533	CDD:189008	116/509 (23%)
		ERAP1_C	607..909	CDD:288671	79/377 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820