DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and erap1a

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	1048	Identity:	237/1048 - (22%)
Similarity:	401/1048 - (38%)	Gaps:	236/1048 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILVLFCTLLSAKLA-------------------ESFVKPLRYNLTI---LTRLGSEDEQNQFEGI 47
            ::.|||.|.:...|                   ...|||..|:|.|   ||.|       .|.|.
Zfish    12 LVALFCALFAGNHAMTVNKNKTVLPFPWDKMRLPEIVKPQHYDLLIHPNLTSL-------TFTGE 69

  Fly    48 VSIDIEATQPTRVIYLNSLNITISR------------QRTWIYRWASGRKIGALQIKRIIKKTSL 100
            |.|.||..|.||.|.|:|.|:.:|:            |...|..:.:..:|.........:|.|
Zfish    70 VQIQIEVKQDTRAIILHSKNLQVSKALLLGSRQHHHHQDLQISEFEANEQIALFSEGFTFEKGS- 133

  Fly   101 IKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTP---RVFYSATRLEPDYAHTVFPC 162
                          :.:::.|..||..| .:|::.|.|....   |:. ::|:.||.:|...|||
Zfish   134 --------------HVVHLEFYANLSDS-FHGFYKGQYTTNSGEVRML-ASTQFEPTHARAAFPC 182

  Fly   163 FDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKE--IENYVSTTFMGSPPLATQQVMWTLHQL 225
            ||:|.|:..:.|.:..:.:::::||||.:......:  :|:...|....|..|.. .::...|.:
Zfish   183 FDEPAFKANFTIRVRRESRHISISNMPKLRTVELADGILEDQFDTMVKMSTYLVA-FIICDFHSI 246

  Fly   226 EKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLF--AYPLPK-----------GA 277
            .|    .:..|..|:|::.|....:.....:....:...|:..|  .|||||           ||
Zfish   247 SK----KSQHGVEISVYTVPEKISQAEYALDTAVTMLDFYDEYFDIPYPLPKHDLAAIPDFQSGA 307

  Fly   278 --DWGGKVDHVVLPRYTEMYSGQGIMVYGEDIVDSGQNGLESLQETLAELVARQWNGLLVNLEDS 340
              :||       |..|.|    .|::...|....|.:.|   :.:.:|..:|.||.|.||.::..
Zfish   308 MENWG-------LSTYRE----SGLLFDPEKSSSSDKLG---ITKVIAHELAHQWFGNLVTMQWW 358

  Fly   341 DEEYVRNG---INYYLSVQVMAMDKEAYNTTHLSK--TRLDVLYHDSLAKVKSIAT------DVK 394
            ::.::..|   ...|:||.:...:.:. |...|.|  |.|.|   |||:....::|      ::.
Zfish   359 NDLWLNEGFAKFMEYVSVNITHPELQV-NDYFLEKCFTALSV---DSLSSSHPVSTPVENPAEIS 419

  Fly   395 ESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQR---------- 449
            |.......:|..|:| :||:..|..::|..|:..:.|:::..:..:..|||....
Zfish   420 EMFDDVSYRKGACIL-NMLRDFLTPEVFKYGIINYLKKHSYQNTVNSHLWESLTNICTSDGLDSG 483

  Fly   450 -----GARRSHQLPT---------GVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQ- 499
                 |....|...|         .|.:..:|::|..|.||||:||:...  |.||:.|.|:.:
Zfish   484 RLKLDGFCSKHTAETPASKWFKEDSVDVGAIMDTWTLQEGFPLITVEVKG--QEVTLKQERFLKG 546

  Fly   500 KYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPE--DWLLINVDAAVPLR 562
            ....|||:..|.||:.||.......|...|   |..||:..|     ||  :|:..|||......
Zfish   547 AESSNSSSFLWQVPLTYITSGSNAVQRFLL---KTERDVFYL-----PEKVEWIKFNVDLRGYYI 603

  Fly   563 VFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWE 627
            |.|:|.....:.:.||.:.|......|..|:.|...|....::|.:..||:..|||.|:
Zfish   604 VHYESGGWDCLIKQLRMNHTVFSSNDRASLIHDIFQLVSIEKVPLDKALNLSLYLSKES------ 662

  Fly   628 TALLNLEKLQSIMRMTTGF-RIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESS 691
                      .||.:|.|| .:..||  ||:|   |..:..|..:.::..   :....|:....|
Zfish   663 ----------EIMPVTQGFSELVPLY--KLME---KRDMQELENQLKSHL---VKLFQPLIDRQS 709

  Fly   692 GTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIK 756
            .                                       |.:.:.|:..|...|...||.....
Zfish   710 W---------------------------------------SDNGSVSERMLRNYLLLFACVRRYP 735

  Fly   757 ECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNS 821
            .|::.|.|.|....:......:|.::..:|...|.|.  :..|..:.:.:..|.:..|:.::..:
Zfish   736 SCVSTATQLFHKWKESDGKMWLPTDVSLVVYTEGART--DDGWDFLLEKYKRSVSPSEKWMIKAA 798

  Fly   822 LSCTTEYWAMQKLLSWALDSKKVPRTMTA----SLLSAVLRSPLGYYVGKQFLIDHSKEILRSKD 882
            ||    |..:...|.|.|:.......|..    |:|.:|.::|.|:.:...||..:..::::..|
Zfish   799 LS----YSPLAHKLQWLLERSSEGEIMKTQDLPSMLISVSKNPKGFKLAWDFLKSNWGKLVKKFD 859

  Fly   883 -----VKLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFD--- 939
                 :..::....:..|||.....: :....:|.....|||.| ::..|:::. :|.|:.|
Zfish   860 LGSSAISRVVVGVTDQYSTKEMLDEV-ELFFGSLAQDQGSGLRS-IQQALEKIQ-QNILWMDRNV 921

  Fly   940 -LLKAIRD 946
             ||||..|
Zfish   922 PLLKAWLD 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	119/521 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	75/387 (19%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	102/433 (24%)
		M1_APN_2	52..525	CDD:189008	119/520 (23%)
		ERAP1_C	592..909	CDD:288671	75/387 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850