DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and trhde.2

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	938	Identity:	237/938 - (25%)
Similarity:	416/938 - (44%)	Gaps:	151/938 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            ::|..|:|    ||....|...|.|.|:|:.|....|::|.|:|..:.:.:    :..::..:|.
Zfish   114 LRPRHYDL----RLTVHMENFSFSGEVNIEFECVNSTKLIVLHSDRLELDK----VLVFSDSKKA 170

  Fly    87 GALQIKRII----KKTSLIKIVIEL-PLRSGEIYTLNMLFSGNLDRSQQYGYF-AGYYDKTPRVF 145
            ||::|:|..    |:..:|.:..|: |||:   |.:|:.|:.:::. :..|:| :.|.....|.|
Zfish   171 GAMRIQRRFHYQPKQVYVIALHREMKPLRT---YKINITFTAHIEH-ELLGFFRSSYMLNGERRF 231

  Fly   146 YSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGS 210
            .:.|:..|.:|...|||||:|.::..:.::|.|:..|.:|||| |||.....| :.:|:..|..:
Zfish   232 LAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESSYQSLSNM-PVEATTSDE-DGWVTNHFSRT 294

  Fly   211 PPLATQQVMWTLHQLEKVYSGPAAAGEN---ITVWSRPHLAEKLA--KVPEMTPNLFSKYETLF- 269
            |.::|..:.|.:..    ::...|..:|   |.:::||...:..:  ....:|..|...|:..|
Zfish   295 PRMSTYYLAWAVCN----FTYKEAVADNGVLIRLYARPDAIQSGSGDYALRITKRLLQFYQDYFK 355

  Fly   270 -AYPLPKGADWGGKVDHVVLPR--YTEMYS-GQGIMVYGEDIVDSGQNGLE---SLQETLAELVA 327
             .|.||       |:|.:.:|:  |..|.: |..:.|..:.::|...:...   .|...:...:.
Zfish   356 VKYSLP-------KLDLLAVPKHPYAAMENWGLSVFVEQKILLDPDVSSFSYQMELTMVVVHEIC 413

  Fly   328 RQWNGLLVNLEDSDEEYVRNGINYYLS-------VQVMAMDKEAYNTTHLSKTRLDVLYHDSLAK 385
            .||.|.||.....::.:::.|..:|..       .....|:|:.:.|..|.    :|:..|.||.
Zfish   414 HQWFGDLVTPVWWEDVWLKEGFAHYFEYIGTDFLFPKWNMEKQRFLTDVLH----EVMLLDGLAS 474

  Fly   386 VKSI------ATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELW 444
            ...|      |||: :.....:..||...||.||...:|..||.:.|.::...:...:|:..:||
Zfish   475 SHPISQQVFEATDI-DRVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLW 538

  Fly   445 EEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDA-KQIVTITQSRY--------YQK 500
            .:.....:|..:   .:::..||:.|..|.|:|::|:.::|: ...:||:|..:        ...
Zfish   539 NKLSEAMQREGK---DINITQVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYDTDAKIQNP 600

  Fly   501 YLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFY 565
            .|.|.|.. |.:|:...|.|.:....|.:....|..:...:.|:.. |.|||.|::.....||.|
Zfish   601 ELFNKSFQ-WQIPLTLAVGNASHISTETIIWVTNKSEAHRVGHVVG-ETWLLGNINQTGYFRVNY 663

  Fly   566 DSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETAL 630
            |.:|.:|:.:.|.::.|.|...:|..|:||..:|:.:|.||.||.|.:|||||.||..|.|..|.
Zfish   664 DLHNWKLLIQQLTRNPTIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQETEFLPWHAAS 728

  Fly   631 LNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTE 695
            ..|.:|..::..|....:|..|:.:.:||.:.          :.|        .|.|
Zfish   729 RALYQLDKLLDRTLDHSLFSDYVLRQVEPKYH----------KLG--------WPAT-------- 767

  Fly   696 SPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLT 760
                  |||.:    ...|:..||                   :|....|:  |||.|..|.|
Zfish   768 ------SPDGS----LMHSAYQTE-------------------ELQREVIM--LACSFGNKHC-- 799

  Fly   761 DAQQRFQAAMDQKSSSS--IPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLS 823
             .:|......|..||:.  ||..:|:||.|.|:....|..|..:...|..|....|:.:||.:|:
Zfish   800 -HRQAVSLISDWISSNKNRIPPNVRDIVYCTGVSLMDEDVWEFIWMKFHSSTAVSEKKVLLEALT 863

  Fly   824 CTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSK------- 881
            |:...:.:.:||:.:|.|..||......::..|.|:|||.::..::..: ..:||.|:
Zfish   864 CSDNIFLLNRLLNLSLTSDLVPDQDVIDVIIHVARNPLGRHLAWRYFRE-KWDILNSRYGEALFM 927

  Fly   882 DVKLI--LTPFINAMSTKAEFSALNDHL 907
            :.|||  :|.|:|   |:||.:.|.:.:
Zfish   928 NSKLISGVTEFLN---TEAELNELKEFI 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	117/483 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	101/368 (27%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	100/415 (24%)
		M1_APN_2	118..568	CDD:189008	117/482 (24%)
		ERAP1_C	649..968	CDD:288671	101/368 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590520
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940