DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and anpepa

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001038326.1	Gene:	anpepa / 558452	ZFINID:	ZDB-GENE-030131-4781	Length:	946	Species:	Danio rerio

Alignment Length:	959	Identity:	211/959 - (22%)
Similarity:	392/959 - (40%)	Gaps:	190/959 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SAKLAESFVKPLRYNLTILTRL-----GSEDEQNQ-FEGIVSIDIEATQPTRVIYLNSLNITISR 72
            |.:|.:|.: |..||:.:...|     .:..||:. |.|..::.:..|:.:..::|:..||.::.
Zfish    61 SLRLPDSLI-PESYNVFLQPYLYAAITNNYTEQSYLFTGNSTVRVNCTKTSSRVFLHVHNINVTA 124

  Fly    73 QRTWIYRWASGRKIGALQIKRIIK-KTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAG 136
            ..  :.:..:..|: .|:..:|.| :|:.:.|.:|:.::....|.:...|.|.| .....|::|.
Zfish   125 VE--VRKSDTNEKL-PLKGYQIFKNETNFLDIHLEVAIKENGTYDIFTEFEGEL-LEDLTGFYAS 185

  Fly   137 YY------DKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKP 195
            .|      |:....|.:.:.|:|..|.|||||||:|..:..:.||::|..:..|.||    |:..
Zfish   186 RYTGKGTDDEDEERFLATSLLQPTDARTVFPCFDEPAMKAVFTITIIHRPEIRARSN----EDGD 246

  Fly   196 YKEIE----NYVSTTFMGSPPLATQQ---VMWTLHQLEKVYSGPAAAGENITVWSRP------HL 247
            .:.|:    :::.|||..:..:::..   :::..|....|..|...   .|.|..|.      |.
Zfish   247 PRTIQINGTDWIRTTFKPTKKMSSYLLGFIIYDTHTFSYVSKGTRT---KIHVHGRSEAIDAGHA 308

  Fly   248 AEKLAKVPEMTPNLFSKYETLFA--YPLPKGADWGGKVDHVVLPRY-TEMYSGQGIMVYGEDIVD 309
            ...|    |.|..:.|.||.:|.  ||:       .|:|.:.||.: .......|.:.|.|
Zfish   309 DYAL----ETTETILSHYENIFGLRYPM-------SKIDQIALPDFGVRAMENWGFISYQE---- 358

  Fly   310 SGQNGL------------ESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLS---VQVMA 359
               :||            |.:...:|..:|.||.|.||.:...::.:::.|...|:|   |:.:.
Zfish   359 ---SGLLYDKETASTFDEEQVTTLIAHELAHQWFGNLVTMSWWNDLWLKEGFATYMSYKGVEAVG 420

  Fly   360 MD---------------KEAYNTTH-LSKTRLDVLYHDSLAKVKSIATDVKESGHQKLRKKKMCL 408
            .|               .::.||:| ||....||   .:.:::..:..|:..|        |...
Zfish   421 WDLKDLIVLREIQTAFQMDSLNTSHPLSMNAYDV---QTSSQISELFDDITYS--------KGAA 474

  Fly   409 LIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQ 473
            ::.||...:|:..|:||::.:..::...:...|:|||        ...:.|.:.:...|::|.::
Zfish   475 VLRMLATRMGENEFMKGVKMYLSKFQFENTVPKDLWE--------CLNMDTHIKVDEFMKTWTEE 531

  Fly   474 PGFPLLTVQRDDAKQIVTITQSRYYQKYL---DNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNS 535
            .|:|:||        |:|.|.....:::|   :...:..|.:|:.|:.....:.:.......|..
Zfish   532 VGYPVLT--------IITDTGDTSQEQFLLKKEGGHDSLWHIPIKYMTLKAGVKEFPNFFTDKGP 588

  Fly   536 RDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLS 600
            ..|.:..  ...::|||.|::.....||.||..|...::..|:::...||.::|.||:|||.:|:
Zfish   589 DPIPDFK--IGKDNWLLANINCTGFYRVNYDEENWNRLTAQLQKNHRIIPLINRGQLIDDAFNLA 651

  Fly   601 WSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTL 665
            .:.||...:.||:..||.|:...:.||:||.||:....:...:..:.....|::.|:.|.::..
Zfish   652 RAHRLNVTIALNLTKYLINDLEYIPWESALKNLDFFTLMFDRSEVYGPIMKYLRNLVTPLYEEY- 715

  Fly   666 NSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTT 730
                      .|..||...|:                      ...|:..|
Zfish   716 ----------EEYTINGTIPI----------------------EKYTDQCN-------------- 734

  Fly   731 ESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSS-IPEEIREIVLCRGIRNG 794
                      .::||  .:||...:.||:|.|:..|.   |.|:.|: |...:|..|.|..:.:|
Zfish   735 ----------QVNAI--TVACSNGLPECITMAKDLFS---DYKNGSNPIHPNLRRAVYCSAVASG 784

  Fly   795 LEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRS 859
            .|..|..|.:.:.::....|:..|..:||||.|.|.:.:.|.:.|:..|:.:....|.:|.:.::
Zfish   785 DEDDWEYVWEEYQKATVAAEKDKLRYALSCTKEIWLLNRYLQYTLEPSKIRKMDMVSTISYIAQN 849

  Fly   860 PLGYYVGKQFLIDHSKEILRSKDVKLI-----LTPFINAMSTKAEFSAL 903
            ..|..:...|:..|...|.:.....:|     |.......||:.|...|
Zfish   850 VAGQPLAWDFIRGHWSYITQEYGAGIISLGSLLDVVTKRFSTEVELEEL 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	111/511 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	83/359 (23%)
anpepa	NP_001038326.1	Peptidase_M1	63..472	CDD:279741	99/449 (22%)
		M1_APN_2	71..535	CDD:189008	111/511 (22%)
		ERAP1_C	602..923	CDD:288671	83/359 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010