DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and si:ch211-106j24.1

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_021327531.1	Gene:	si:ch211-106j24.1 / 555478	ZFINID:	ZDB-GENE-130530-595	Length:	960	Species:	Danio rerio

Alignment Length:	996	Identity:	218/996 - (21%)
Similarity:	371/996 - (37%)	Gaps:	209/996 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSE-DEQNQFEGIVSIDIEATQPTRVIYL--NSLNITISRQRTWIYRWASG 83
            :.|..||:|:..::..: :....|.||..:.....:.|.:|.:  |.||:|:...|.......||
Zfish    72 LSPQYYNITLWPQMVMDANGMYIFTGISDVMFTCVKKTDLILIHSNKLNLTLFNGRHAKLTGMSG 136

  Fly    84 RKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVFYSA 148
            ....|::...:..:|..:.|.::..|..|:.|.|:..|:|.|....:..|.:.|.:...:...:.
Zfish   137 VTAPAIKSTWLQTQTQYLVIQLKGKLNPGKSYWLHTEFTGELADDLEGFYRSEYMEDGEKKIIAI 201

  Fly   149 TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPP-------VEEKPYKEIENYVSTT 206
            |:::..||...|||||:|..:..:||.|:|||...||||...       ::|.|      ...||
Zfish   202 TQMQATYARKAFPCFDEPGMKAVFNIILIHDRGMTALSNSQEIRTEDVIIDEMP------VTRTT 260

  Fly   207 FMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHL-----AEKLAKVPEMTPNLFSKYE 266
            |..:..::|..|.:.:.....: :....||..:.:|:|...     .:....:.:.....|..|.
Zfish   261 FEPTARMSTYLVAFVVSDFSYI-NNEDKAGVLVRIWARKKAIDDGQGDYALSITQPILEFFESYY 324

  Fly   267 TLFAYPLPKGADWGGKVDHVVLPRYTEMYSGQ----GIMVYGE-----DIVDSGQNGLESLQETL 322
            .. :|||.|.       |.|.||.:.   ||.    |::.|.|     |...|.....:.:...:
Zfish   325 NT-SYPLSKS-------DQVALPDFN---SGAMENWGLVTYRETALLYDPQTSANGNKQRIATVV 378

  Fly   323 AELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKT---RLDVLYHDSLA 384
            :..:|..|.|.||.|:..::.::..|...|  |:.:..|       |...|   :..::.:|
Zfish   379 SHELAHMWFGNLVTLKWWNDLWLNEGFASY--VEYLGAD-------HAEPTWNIKDQIILYD--- 431

  Fly   385 KVKSIATDVKESGHQKLRKK-------------------KMCLLIHMLKVALGDKLFLKGLQEFF 430
            ..::.|.|...|.|...||:                   |...::.||...|.:.:|.|||..:.
Zfish   432 MQRAFAVDSLTSSHPLSRKEEEVNTPAEISEMFSTISYSKGAAVLKMLSEFLTEPVFAKGLSNYL 496

  Fly   431 KRYANSSASSKELWEEFQRGARRSHQLPTGVSLP----TVMESWMKQPGFPLLTVQRDDA----- 486
            |::|..|:...:||:..|:..   .|.| |:.||    .:|..|:.|.|||::|:.....
Zfish   497 KQFAFGSSVHSDLWDHLQKSL---DQAP-GMKLPRSIHEIMSRWILQMGFPVITIDTRTGNVSQK 557

  Fly   487 -----KQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIAN 546
                 |..|...:|.:         |..|:||:.::.:.....|: ||         |:.|.|..
Zfish   558 HFLVEKDAVVERKSEF---------NYEWFVPIKWMKKGQVQDQM-WL---------LQKSAIHK 603

  Fly   547 P-----EDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLP 606
            |     .:|:|.|...:...||.||..|.:.:...|..:...||.::|.|::|||.:|:.:..:.
Zfish   604 PMKVSKGEWVLANHKVSGYFRVNYDHGNWERLLSQLETNHQTIPVVNRAQILDDAFNLARASIIN 668

  Fly   607 YNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTK 671
            ..:.|....||..|...:.||.||.:|.....:......:...:.|::|.::|.|
Zfish   669 ITLALRTTKYLVREREYIPWEAALRSLNYFFQLFDRNEVYGALQAYLKKQVKPLF---------- 723

  Fly   672 ARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTT 736
                             |..||.                   |||.|:.|:             .
Zfish   724 -----------------EHFGTI-------------------SSNWTKVPN-------------G 739

  Fly   737 KSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIM 801
            .:|.....|...|||...::.|....:..|:..|.....:.|...:|..|.|..|..|....|..
Zfish   740 HTDQFTQIIALSLACGTGVEGCREITKSWFKKWMQNPRVNPIHPNLRSTVYCNAIAAGGADEWNF 804

  Fly   802 VRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTAS----LLSAVLRSPLG 862
            ...||.::....|...|..:|:||...|.:.:.|.::::.:|:.:....|    :.|.|:..||.
Zfish   805 GWQMFQKATVAAEAVKLRAALACTKVPWLLNRYLEYSINPEKIRKQDATSTIGYIASNVIGQPLA 869

  Fly   863 Y-------------YVGKQFLIDHSKEILRSKDVKLILTPFINAMSTKAEFSALNDHLHRNLPSS 914
            :             |....|........:.||    ..|||        |.|.|......|..:.
Zfish   870 WDFVRANWDYFFKVYGTGSFTFSRLISDITSK----FCTPF--------ELSQLKRFQKDNAETG 922

  Fly   915 MVSG---LSSTLESGLDRVNW 932
            ..||   |...:|....::.|
Zfish   923 FGSGTQALQQAIERTTAKIKW 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	116/501 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	82/397 (21%)
si:ch211-106j24.1	XP_021327531.1	M1_APN_2	77..543	CDD:189008	116/499 (23%)
si:ch211-106j24.1	XP_021327531.1	PepN	170..943	CDD:223385	195/896 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590568
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950