DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	967	Identity:	216/967 - (22%)
Similarity:	379/967 - (39%)	Gaps:	161/967 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTILTRLGSED-EQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIG 87
            |..||:|:..||..:| ....|.|...:.....:.|.:|.::|.|:..|......:....|  :|
Zfish    76 PEYYNITLWPRLTKDDLGMYIFTGKSGVAFLCVKETDLILIHSSNLNYSLTAEKHHAELMG--LG 138

  Fly    88 ALQIKRIIK-----KTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVFYS 147
            ..:...|:|     :|..:.|.:...|:.|:.|.|...|.|.|.......|.:.|.:.......:
Zfish   139 GTRAPVILKTWFQDQTEFMVIQLRENLQVGKSYWLYTEFQGELADDLGGFYRSEYVENGVEKVVA 203

  Fly   148 ATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSN-MPPVEEKPYKEIENYVSTTFMGSP 211
            .|:::|..|.|.|||||:|..:..:::||:|....|||:| |....|....|.:..:.|.|..:.
Zfish   204 TTQMQPTAARTAFPCFDEPSMKAVFHLTLIHPPGTVALANGMETGTENITIENQQVLQTRFEPTE 268

  Fly   212 PLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEK------LAKVPEMTPNLFSKYETLFA 270
            .::|..:.:.:.:...:.|...|....:.:|.|....|.      |.....:...|.|.|.|  .
Zfish   269 KMSTYLLAFVISEFPSIQSPLGANKILVRIWGRREAIENGEGDYALNVTFPVLKYLESYYNT--T 331

  Fly   271 YPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGEDIV-----DSGQNGLESLQETLAELVARQ 329
            |||.|.       |.:.||.::. .....|::.|.|..:     .|.....|.:...::..:|..
Zfish   332 YPLSKS-------DQIALPDFSAGAMENWGLVTYRETFLFYEPKVSSHEDKEGVITVISHELAHM 389

  Fly   330 WNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDVK 394
            |.|.||.:...::.::..|...|:|.......:..:|...|..  |..:|       ::...|..
Zfish   390 WFGNLVTMRWWNDLWLNEGFASYVSYLAADYAEPTWNIKELMV--LQQVY-------RAFTVDAL 445

  Fly   395 ESGH------------QKLRK-------KKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASS 440
            .|.|            |::.:       .|...::.||...|.:.:|.|||..:.:.:|.|:...
Zfish   446 VSSHPLSSREDAVNTPQQIEELFDAVTYSKGAAVLRMLSEFLSESVFAKGLHNYLQEHAYSNTVY 510

  Fly   441 KELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYL--- 502
            .:||::.|..|.....:....|:..:|..|:.|.|||::|:.        |.|.|...|.:|
Zfish   511 TDLWKKLQEVADSDGNVHLPASIEEIMNRWILQAGFPVVTID--------THTGSISQQHFLIDP 567

  Fly   503 ---DNSSNDC---WWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPL 561
               .|..:|.   |:||:.::.....:.| .||..:..|.::::     ...:|:|.|::.....
Zfish   568 EAVVNKPSDYNYEWFVPITWMKNGRNMGQ-HWLLNKSTSYELMK-----TETNWILANLNVTGYY 626

  Fly   562 RVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVW 626
            ||.|||.|.:.:.:.|..|...||.|:|.|::|||.:|:.:..|...:.|....|||||...:.|
Zfish   627 RVNYDSQNWERLIKQLTSDHQAIPVLNRGQIIDDAFTLARAKILNITMALRTTQYLSNEKEYIPW 691

  Fly   627 ETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPA---FKTTLNSLSTKARTGSEIPINTKSPVTT 688
            |:|:.|||....:...|......:.|:::.:||.   ||..
Zfish   692 ESAIRNLEYFFLMFDRTEVRGPLEAYLRRKVEPLFHYFKVI------------------------ 732

  Fly   689 ESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQF 753
                                     :||.|..|  |...|...         .|:||  .:||:.
Zfish   733 -------------------------TSNWTRKP--TRHMDQYN---------QLNAI--TMACKT 759

  Fly   754 EIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSIL 818
            .:|.|.......::..|...:.:.:|.:::.:|.|..|..|....|.....||..|....|...|
Zfish   760 RVKACSELTSMWYRQWMKDPNVNPVPSDLKTVVYCNAIAAGGVEEWDFGWAMFKNSTVAAEAEKL 824

  Fly   819 LNSLSCTTEYWAMQKLLSWALDSKKV-PRTMTASLL---SAVLRSPLGYYVGKQFLIDHSKEILR 879
            :..||||.|.|.:.:.|.:|:|...: .:.:|..::   |.|:..||.:    .|.  .:|..|.
Zfish   825 MYGLSCTKEPWLLNRYLHYAIDPNLIRKQDVTYPIVYIASNVIGQPLAW----DFF--RAKWQLM 883

  Fly   880 SKDVKLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDR----VNW 932
            :.:.::::...:...||:.:...| ......:..|.||..:..:|..:::    |.|
Zfish   884 TTEFRVLILGIVKTFSTEFQLQQL-QRFQEEVAESGVSLGTHAIEQAIEQTKANVKW 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	108/489 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	87/384 (23%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	108/487 (22%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	88/388 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920