DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and SP1029

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster

Alignment Length:	1019	Identity:	259/1019 - (25%)
Similarity:	464/1019 - (45%)	Gaps:	166/1019 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKILVLFCTLLSAKLA------------------ESFVKPLRYNLTILTRLGSEDEQNQFEGIVS 49
            :|..:||...|...||                  .:.::|.:|:|.|||.| ...|..:|.|.|.
  Fly     1 MKWFLLFVAALGLGLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLL-ENPEDLRFSGSVK 64

  Fly    50 IDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELP------ 108
            |.|||.:.|:.:.|:|.|:||...:..:      |:||...     ||.:.:......|
  Fly    65 ILIEALENTKNVTLHSKNLTIDESQITL------RQIGGEG-----KKENCVSSTAVNPSHDFYI 118

  Fly   109 ------LRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRV--FYSATRLEPDYAHTVFPCFDD 165
                  |.:|..|.|.|.|:.:|:|..:..|.:.|.|....:  :.|.|:.||..|...|||||:
  Fly   119 LNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDE 183

  Fly   166 PRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQL-EKVY 229
            |.|:.|:.:||.:.:||.|:||||..|.||::.:.:|:...|..|.|::|..|.::::.. .|..
  Fly   184 PDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPS 248

  Fly   230 SGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFA--YPLPKGADWGGKVDHVVLPRYT 292
            :.|.:|  ....|:||:..::.....:..|.:...||..|.  :|||       |:|.:.:|.::
  Fly   249 TLPNSA--LFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLP-------KIDQIAVPDFS 304

  Fly   293 E-MYSGQGIMVYGED--IVDSGQNGLESLQ---ETLAELVARQWNGLLVNLEDSDEEYVRNGINY 351
            . .....|::.|.|.  :..:..:.|...|   ..:|..:|.||.|.||.::...:.::..|...
  Fly   305 AGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFAT 369

  Fly   352 Y--------LSVQVMAMDKEAYNTTHLSKTRLDVLYHD-SLAKVKSIATDVKESGHQKLRKKKMC 407
            |        ::.:..:|::|:.:.. |:..|.|.|... .:::...:.:::.||..| :..:|..
  Fly   370 YVASLGVENINPEWRSMEQESLSNL-LTIFRRDALESSHPISRPIQMVSEISESFDQ-ISYQKGS 432

  Fly   408 LLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMK 472
            .::.|:.:.||::.|..|||.:.::::..:|....|||...:.|.:...||....:.::|:||..
  Fly   433 TVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTL 497

  Fly   473 QPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSS------NDCWWVPVAYIVR-----NLTLPQV 526
            |.|:|::.|.||.|.:...:.|.|    ||.|:.      ..|||||::|..:     |.|.|:.
  Fly   498 QTGYPVINVTRDYAARTAKLNQER----YLLNTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKA 558

  Fly   527 EWLGCQKNSRDILE-LSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQ-DFTQIPELSR 589
             |:.|.||...:.: :..:..|:.|::.|...:...:|.||:.|.:|:.|.|.. ||.:|..::|
  Fly   559 -WMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINR 622

  Fly   590 IQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQ 654
            .||:||||.|:|:|...|.:.:.:|.||..|...|.|::|..||:::..|:|.|..|..||.||:
  Fly   623 AQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMK 687

  Fly   655 KLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTE 719
            |||.|.:: .||.::.   |.|.||
  Fly   688 KLILPIYE-HLNGIND---TFSAIP---------------------------------------- 708

  Fly   720 SPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDA-----QQRFQAAMDQKSSSSIP 779
                            .:..:.|..::...|||:::.:|:..|     ..|.:|..|:|  :.:|
  Fly   709 ----------------QQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEK--NPVP 755

  Fly   780 EEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKV 844
            ..:|..|.|..|::|.:..|..:...:.:|....|:..:|.:|.|:.|.|.:|:.|....|.|:.
  Fly   756 INVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEA 820

  Fly   845 PRTMTAS-LLSAVLRSPLGYYVGKQFLIDHSKEILR-----SKDVKLILTPFINAMSTKAEFSAL 903
            .|...:. ...||..:.:|:.:.|::.:|:...|.:     :||:..:|:|....:.|.::|:..
  Fly   821 IRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEF 885

  Fly   904 NDHLHRNLPS--SMVSGLSSTLESGLDRVNWRNNLYFDLLKAIR 945
            .|.::.:..|  .:...:..|||..|..|.|:...|..:.::|:
  Fly   886 KDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQMSRSIQ 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	127/483 (26%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	96/391 (25%)
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	108/420 (26%)
		M1_APN_2	43..502	CDD:189008	127/481 (26%)
		ERAP1_C	583..908	CDD:288671	93/386 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850