DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and Npepps

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_536320.1	Gene:	Npepps / 50558	RGDID:	619962	Length:	920	Species:	Rattus norvegicus

Alignment Length:	942	Identity:	215/942 - (22%)
Similarity:	378/942 - (40%)	Gaps:	186/942 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            |.|:.|:|.:...|    ....|||.:....:..|.|..|.:|..:|.|.   |..|......:|
  Rat    59 VSPINYSLCLKPDL----LDFTFEGKLEAAAQVRQATNQIVMNCADIDII---TASYAPEGDEEI 116

  Fly    87 GALQIKRIIKKTSLIKIVIELP--LRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVFYSA- 148
            .|....   .:....|:.:..|  |::| ..||.:.|.|.|:...:..|.:.|......|.|:|
  Rat   117 HATGFN---YQNEDEKVTLSFPSTLQTG-TGTLKIDFVGELNDKMKGFYRSRYTTPAGEVRYAAV 177

  Fly   149 TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPL 213
            |:.|...|...|||:|:|..:..::|:||..:..||||||..::.|||.:.||.|...|..:|.:
  Rat   178 TQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVM 242

  Fly   214 ATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLF--AYPLPKG 276
            :|..|.:.:.:.:.|.: .:..|..:.|::....||:.....|:.......|:..|  .||||
  Rat   243 STYLVAFVVGEYDFVET-RSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLP-- 304

  Fly   277 ADWGGKVDHVVLPRYTE-MYSGQGIMVYGED--IVDSGQNGLESLQETLAELV----ARQWNGLL 334
                 |:|.:.:..:.. .....|::.|.|.  ::|. :|...|.::.:|.:|    |.||.|.|
  Rat   305 -----KIDLIAIADFAAGAMENWGLVTYRETALLIDP-KNSCSSSRQWVALVVGHELAHQWFGNL 363

  Fly   335 VNLEDSDEEYVRNGI--------------NYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAK 385
            |.:|.....::..|.              .|.:..|.::.|          .||...|  |:|..
  Rat   364 VTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSAD----------YTRAQEL--DALDN 416

  Fly   386 VKSIATDVKESGH--------QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKE 442
            ...|...|   ||        ..:...|...:|.||...:|||.|.||:..:..::...:|::::
  Rat   417 SHPIEVSV---GHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATED 478

  Fly   443 LWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAK--QIVTITQSRYYQK--YLD 503
            |||..:..        :|..:..||.:|.||.||||:.|:.:..:  :::.::|.::...  |:
  Rat   479 LWESLESA--------SGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYV- 534

  Fly   504 NSSNDC--WWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHI---ANPEDWLLINVDAAVPLRV 563
              ..||  |.||:.  :.....|....|   |...|..|:|.:   ..|:.|:.:|:......|.
  Rat   535 --GEDCPQWMVPIT--ISTSEDPNQAKL---KILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRT 592

  Fly   564 FYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWET 628
            .|.|..|:.:...:|.  ..:|.:.|:.|.:|..||:.:|.:.....|.|:....||.:..||..
  Rat   593 QYSSAMLESLLPGIRD--LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSD 655

  Fly   629 ALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGT 693
            ...||..|.:::..|.    |...:|:.::..|                      ||: .|..|.
  Rat   656 LSCNLGILSTLLSHTD----FYEEIQEFVKDVF----------------------SPI-GERLGW 693

  Fly   694 TESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLAC----QFE 754
            ...|                                        .:..|.|:|..|..    :..
  Rat   694 DPKP----------------------------------------GEGHLDALLRGLVLGKLGKAG 718

  Fly   755 IKECLTDAQQRFQAAMDQKS--SSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSI 817
            .|..|.:|::||:..::.|.  |:.:...:...||..|....|:   ||:: :..:::..:|::.
  Rat   719 HKATLEEARRRFKEHVEGKQILSADLRSPVYLTVLKHGDGTTLD---IMLK-LHKQADMQEEKNR 779

  Fly   818 LLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVL-RSPLGYYVGKQFLIDHSKEI---- 877
            :...|..|.....:||:|::||..:..|:. |.|::..|. .|..|.....:|:.|:.:|:
  Rat   780 IERVLGATLSPELIQKVLTFALSEEVRPQD-TVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRY 843

  Fly   878 ----LRSKDVKLILTPF-INAMS--TKAEFSA 902
                |.|:.:||.:..| ::.|:  .||.|.:
  Rat   844 QGGFLISRLIKLSVEGFAVDKMAGEVKAFFES 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	120/485 (25%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	74/370 (20%)
Npepps	NP_536320.1	Peptidase_M1	54..442	CDD:279741	101/417 (24%)
		M1_APN_2	62..505	CDD:189008	120/485 (25%)
		ERAP1_C	580..891	CDD:288671	74/370 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820