DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Lvrn

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	940	Identity:	221/940 - (23%)
Similarity:	405/940 - (43%)	Gaps:	120/940 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTILTRLGSEDEQN---QFEGIVSIDIEATQPTRVIYLNSLNITISRQRTW--IYRWASG 83
            ||.|:|.:..||..::...   .|.|.|:|.:..|..|..:.|:|..:...:...|  :......
  Rat   101 PLHYDLELWPRLQPDNLSTPSLTFTGRVNITVRCTVATSTLLLHSFFLNYKQVEVWGPLAPDTRN 165

  Fly    84 RKIGALQIKRIIKKTSLIKIVIEL--PLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY-DKTPRVF 145
            ..:|.:.::.:.....:..:|::|  .|..|..|.||..|||.:.:....|.|...| |:.....
  Rat   166 ATVGRVPLENVWFALDMQYVVLDLGQSLDPGSSYELNFDFSGQVLQEGSEGLFLNLYTDEDQLRA 230

  Fly   146 YSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEI--ENYVSTTFM 208
            ..||::||.:|..||||||:|..:..:|||::|...||||||||.:.:....::  ..:..|:|.
  Rat   231 LIATQMEPTFARHVFPCFDEPALKATFNITIIHHPGYVALSNMPQLGQSHRIDVNGSRWTVTSFH 295

  Fly   209 GSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSR-PHLAE-KLAKVPEMTPNLFSKYETLF-- 269
            .:|.:.|..|...:...:  |......|:.|.||:| ..:|: .|......|..:||..|.||
  Rat   296 TTPRMPTYLVALVICDFD--YVSRTERGKEIRVWARKDDIADGYLDFAANHTGPVFSFLEDLFNI 358

  Fly   270 AYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGEDIV----DSGQNGLESLQETLAELVARQ 329
            :||||       |.|.:.||.:.. .....|:|::...::    |........:...|:..|..|
  Rat   359 SYPLP-------KTDIIALPTFVNGAMENWGLMIFDASLLLELDDDLPEKRAMILSILSHEVGHQ 416

  Fly   330 WNGLLVNLEDSDEEYVRNGINYYLSVQV--MAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATD 392
            |.|.||.:...:..::..|...|..|.:  ....|...|.........|:|..|...:.::::|.
  Rat   417 WFGNLVTMSWWNNIWLNEGFASYFEVGLTNYFYPKVPRNMIFFLTVLHDILEDDHSLESRAVSTP 481

  Fly   393 VKE-SGHQKLRK-------KKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQR 449
            |:. :..:::.:       ||...:..||...|...||:..|:.:.:.::.|:|...:||...|.
  Rat   482 VENFTETREINRLFDIYTYKKGACMAWMLAGFLSQHLFINALKSYLETFSYSNAEQDDLWRHIQM 546

  Fly   450 GARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNS---SNDCWW 511
            .......:....::..:|:||..|.|||::|:.....    .:.|..:|.:.::|.   |::.|.
  Rat   547 AIDEQSIIHLPATVKRIMDSWTHQSGFPVITLNASTG----VVKQEPFYLERVENQTLLSHNTWI 607

  Fly   512 VPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEA 576
            ||:.::...:|.|.| ||  .|:|.....:....:..||:::|.:.....||.||....:.:::.
  Rat   608 VPIFWMKNGITQPLV-WL--DKSSMIFPGMKLSDSDSDWVILNFNVTGYYRVNYDKLGWKKLNQQ 669

  Fly   577 LRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMR 641
            |.:|...||.::|:|||.||.:||.:..:.....|::..|::.|..:|||...|:||...:.:
  Rat   670 LEKDPKAIPVINRLQLVSDAFALSKNNYIEIETALDLTKYIAKEDEILVWFEVLVNLINREVV-- 732

  Fly   642 MTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTA 706
                :.:...|:..|::..|...|||:.|           ..|.:..|:..:.:
  Rat   733 ----YDVKNYYLYPLLKKYFLKRLNSIWT-----------IYSAIIRENMASLQ----------- 771

  Fly   707 ESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMD 771
                                       |...|.|.|.. .:..||...:::||..:::.|:..|
  Rat   772 ---------------------------DNFLSLLPLKK-FFETACWLGLEDCLQLSRELFRKWM- 807

  Fly   772 QKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFF-ESENDKERSILLNSLSCTTEYWAMQKLL 835
            ....::||.:|.::|||..|..|....|..:.:::. ::|..::...|::::.|:.:...:.:.:
  Rat   808 AHPETAIPPQIEKVVLCNAIALGSNKDWDFLFNLYINKTEEQEDLFHLVHAMGCSKDPRTLNRFM 872

  Fly   836 SWALDSKKVP-RTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSKDVKLILTP-FINAMSTKA 898
            .:  |....| |....:|:..|..|.:|.||.|.|||::...:..|..:..:|.. |::..:|.|
  Rat   873 EY--DITVFPSRFNETNLIEVVAESEVGRYVAKDFLINNWVAVYESPSLSPLLQQYFVSVWTTIA 935

  Fly   899 EFSALN---DHLHRN-------LPSSMVSG 918
            |.|:::   |..||:       :|...|.|
  Rat   936 EHSSVHLREDCQHRSAGYGVAAVPQHCVGG 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	118/480 (25%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	83/381 (22%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	116/475 (24%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	71/330 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950