DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG14516

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	991	Identity:	214/991 - (21%)
Similarity:	393/991 - (39%)	Gaps:	187/991 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRK- 85
            ::||:||:||..:|..   ...|.|.|.|.|...:....|.:::..:.|||....::|..:..:
  Fly   118 IRPLKYNITIEPQLSG---NFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEP 179

  Fly    86 ------------IGALQIKRIIKKTSLIKIVIEL--PLRSGEIYTLNMLFSGNLDRSQQYGYFAG 136
                        :||.|.           .||||  .|.....|.:::.|.|.::     .|..|
  Fly   180 EGDGLRIHKQYLVGAKQF-----------FVIELYDKLLKDVEYVVHLRFDGIIE-----DYLQG 228

  Fly   137 YYDKTPRV-----FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPY 196
            :|..:..|     :.::|:.:...|...|||||:|..:..:.:.:...|....:||||.|....:
  Fly   229 FYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDH 293

  Fly   197 KEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNL 261
            ..:.:||...|..|.|::|..|.:.:.....:.||      |..||:|....:.......:.|.:
  Fly   294 ATMPSYVWDHFAESLPMSTYLVAYAISDFTHISSG------NFAVWARADAIKSAEYALSVGPRI 352

  Fly   262 FSKYETLF--AYPLPKGADWGGKVDHVVLPRYTEMYSGQ----GIMVYGED--IVDSG---QNGL 315
            .:..:..|  .:|||       |:|.:.||   |..:|.    |::.:.|.  :.|.|   .|..
  Fly   353 LTFLQDFFNVTFPLP-------KIDMIALP---EFQAGAMENWGLITFRETAMLYDPGVATANNK 407

  Fly   316 ESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSK---TRLDV 377
            :.:...:...:|.||.|.||......:.::..|...|:  :.:..|..|.....|.:   ..|..
  Fly   408 QRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYM--EYLTADAVAPEWKQLDQFVVNELQA 470

  Fly   378 LYH-DSLAKVKSIATDV---KESGH--QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANS 436
            ::. |:|:....|:.:|   :|...  .::...|...:|.|:...|.:.:|.:||.::.:..|.:
  Fly   471 VFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYN 535

  Fly   437 SASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKY 501
            ||:..:||......|:.|..|....|:..:|::|..|.|:|::.|.|.....::.:.|.|:.  |
  Fly   536 SATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFV--Y 598

  Fly   502 LDNSSND---CWWVPVAYIVRN-----LTLPQVEWLGCQKNSRDILELSHIANPE----DWLLIN 554
            .:.:..|   .|::|:.:...:     .|.| ..|:...|       |..:.|.|    .|.:.|
  Fly   599 TNTTREDESLLWYIPITFTTDSELNFANTRP-TTWMPRTK-------LYELENRELSLAKWFIFN 655

  Fly   555 VDAAVPLRVFYDSYNLQLISEALR--QDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYL 617
            |......||.||..|...|:|.|.  .:|..|...:|.||:||.::|:....|.|...:|:..||
  Fly   656 VQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYL 720

  Fly   618 SNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINT 682
            .:|...:.|:.|:.|...:.|:...:..:.:.|.|:.|.::..:
  Fly   721 GHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVY--------------------- 764

  Fly   683 KSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLS---A 744
                  :..|..:|.|.:|                                     |:.:.   |
  Fly   765 ------DQVGFKDSQDESE-------------------------------------DILVKLKRA 786

  Fly   745 ILYRLACQFEIKECLTDAQQRFQAAM---DQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMF 806
            .:..:||....:||:.:|.:.||..|   :..|::.|...:|.:|.|..|:.|.|..|....:.|
  Fly   787 DILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERF 851

  Fly   807 FESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLI 871
            .::....|:.:|||:|.|:.|.|.:.:.|...:..:.:.:.....:.:||..:.:|..:...||.
  Fly   852 LKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLR 916

  Fly   872 DHSKEI--LRSKDVKLILTPF------INAMSTKAEFS--ALNDHLHRNLPSSMVSGLSSTLESG 926
            ::.:||  .....:..|.|.|      .|:.....||.  ..:.|...:.|   |..:...:|:.
  Fly   917 NNWQEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDRP---VQQIVEHIETS 978

  Fly   927 LDRVNWRNNLYFDLLK 942
            :|   |.|..|..:::
  Fly   979 VD---WMNKNYKSIVR 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	111/491 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	81/395 (21%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	92/423 (22%)
		M1_APN_2	121..576	CDD:189008	111/491 (23%)
		ERAP1_C	652..974	CDD:288671	80/388 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462075
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850