DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG42335

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	1059	Identity:	198/1059 - (18%)
Similarity:	393/1059 - (37%)	Gaps:	292/1059 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFCTLL------SAKLAESFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRV----IY 62
            |.|:||      :....|..|.|..|||||.. |.:..|...|:|.|||.:.......|    ::
  Fly    11 LLCSLLICVTNAADYRLEGSVVPSHYNLTIGV-LRNSVEPTIFDGEVSITLRVVGTLEVQQIILH 74

  Fly    63 LNSLNITISRQRTWIYRWASGRKIGALQIKRIIKK--TSLIKIVIELPLRSGEIYTLNMLFSGNL 125
            .::|:||    ..|:.. |:|.::.|:.|.|:|.:  |..:::.:....:.|:.|||...::|::
  Fly    75 ADTLDIT----ECWLLD-AAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHI 134

  Fly   126 DRSQQYGYF-AGYYDKTPRV--FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSN 187
             |:...|:| |.|.::...|  :.:.|:::...|..|.||||:|..:..:.:.:|....|.:::|
  Fly   135 -RTDMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIAN 198

  Fly   188 MPPVEEKPYKE---IENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAE 249
            ....|.|...:   ::::..|..|.:..||.....::....|..::          |.:||...:
  Fly   199 TKLKETKALSQDRFVDHFKETPVMSTYLLAFMVANYSARGNESEFA----------VLTRPEFYD 253

  Fly   250 KLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKV-DHVVLPRYTEMYSGQ---GIMVYGEDIV-- 308
            .......:...:.|.|..||..|.   |:.|..| .:...||:.  ::|.   |:::|.:|::
  Fly   254 NTEFSYHVGQQVVSAYGELFQSPY---AELGNDVLQYASSPRFP--HNGMENWGLIIYSDDVLIQ 313

  Fly   309 DSGQNGLESLQETLAELVARQ----WNGLLVNLEDS-----------DEEYVRNGINYYLSVQVM 358
            :.|.:...|.:|....::|.:    |.|      ||           :|.:.|. ..|:::.|:
  Fly   314 EPGYSDDWSDKEFAIRIIAHETSHMWFG------DSVTFSWWSYFWLNEAFARY-YEYFMAHQL- 370

  Fly   359 AMDKEAYNTTHLSK----TRLDVLYHDSLAKVKSIATDVKESGHQKLRK---------------- 403
                  |...||.:    .::.:::          .||. ::|.|.:..
  Fly   371 ------YPDYHLDEQFVVRQMQLIF----------GTDA-QNGTQPMTSPESEIQTPSQIAYKFS 418

  Fly   404 -----KKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKEL-------WEEFQRGARRSHQ 456
                 |..| ::.|.:..:|.:.|...::.:.::|..::.....|       |.:.|
  Fly   419 GIAYAKGAC-IVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWPKNQ-------- 474

  Fly   457 LPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDC--WWVPVAYIVR 519
               .|.|...:..:.:|.|:|::.|:.....::||:.|||:... .|:.||..  :.||:.:...
  Fly   475 ---DVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLN-KDDGSNATLKYTVPITFTTN 535

  Fly   520 ------NLT-------LPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQ 571
                  |||       ...|.||             ...:|.||:|.|:..:...|||||
  Fly   536 LERDFYNLTPYKYLHKTVNVLWL-------------DFTSPIDWILFNLRQSNYQRVFYD----- 582

  Fly   572 LISEALRQ---------DFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWE 627
               :.||:         :.:.||..:|.|::||..:.:.:..:.|......:.||:.|...:.|.
  Fly   583 ---DTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWY 644

  Fly   628 TALLNLEKLQSIMRMTTGFRI--FKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTES 690
            ..   .|.|.::.:..|..::  |::|:..:....|                           |.
  Fly   645 AV---YENLNTVAKRLTPEQLPDFRIYLSSITAAVF---------------------------EK 679

  Fly   691 SGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEI 755
            .|.                    ..|..::|                .|::....|.:..|:::.
  Fly   680 LGV--------------------GWNAQDTP----------------LDVANRNKLIKWLCRYQA 708

  Fly   756 KECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVH-WIMVRDMFFESENDKERSILL 819
            ..|......:|....:..|     .:.||...|..  :|.:.: :.|:...::......|:::|.
  Fly   709 SNCRPKVNVQFVTGHEVPS-----PDYRETFYCAA--SGADYNSYTMLWGQYYLENRTSEKNMLW 766

  Fly   820 NSLSCTTEYWA-MQKLL---SWALDSKKVPRTM----TASLLSAVLRSPLGYYVGKQFLIDHSKE 876
            .::|||.:|.. ..|::   :.:::.||:....    ...|:.|:.          :.:.::..|
  Fly   767 AAISCTRDYETHYHKMIISGTESVEQKKIGIARMYEENPDLVQAIF----------EMITENIME 821

  Fly   877 ILRS----KDVKLILTPFINAMSTKAEFSALNDHLHRN----------LPSSMVSGLSSTLESGL 927
            :..:    .|...::.......:|:.:...|.:..:.|          |..|:|     |:|..|
  Fly   822 LAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLV-----TVEKNL 881

  Fly   928 DRVNWRNNLYFDLLKAIRD 946
               ||.......|:|.:.|
  Fly   882 ---NWAETHLEGLVKYLAD 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	102/516 (20%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	63/411 (15%)
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	92/445 (21%)
		M1_APN_2	34..492	CDD:189008	102/516 (20%)
		ERAP1_C	567..874	CDD:288671	58/397 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020