DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG31233

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001303538.1	Gene:	CG31233 / 42557	FlyBaseID:	FBgn0051233	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	202/969 - (20%)
Similarity:	378/969 - (39%)	Gaps:	187/969 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTR--VIYLNSL----------NITISRQRTW 76
            |..|.:::.|.:.:.|  ..|.|.|:|.:.....|.  |::...|          .:|.:..:..
  Fly    64 PSHYAVSLSTNVHTGD--TVFNGTVAITLSVLNTTTKIVVHARQLENFTASIIQQGVTEAVAQEL 126

  Fly    77 IYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKT 141
            :|.:.:.|:.      ....||.|     ..|..:..|.|:|  :.|:|.......|.:.|.|:.
  Fly   127 VYEYEAEREF------LTFSKTGL-----TFPEDTTWILTIN--YQGHLRTDNGGFYLSTYTDEE 178

  Fly   142 PRVFYSA-TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVST 205
            ....|.| |:.|...|...|||:|:|..|..:.||:.||..|.|:||| ||:......:..:..|
  Fly   179 GNTKYLATTQFESTDARHAFPCYDEPSKRAEFTITIKHDPSYNAISNM-PVDSSSTSGVTVFQKT 242

  Fly   206 TFMGSPPLA--TQQVMWTLHQL----EKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSK 264
            ..|.|..:|  ..:.:::..:|    ::|:|......|.....:...|.||         .|...
  Fly   243 VNMPSYLVAFIVSEFVFSEGELNGLPQRVFSRNGTEHEQEWALTTGMLVEK---------RLSGY 298

  Fly   265 YETLFAYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGED-IVDSGQNGLESLQETLAELVA 327
            ::..||.|         |:|...:|.:.. .....|:..|.|: ::.:.:|...|.|..:|.:.|
  Fly   299 FDVPFALP---------KLDQAGIPDFAAGAMENWGLATYREEYLLYNTENSTTSTQTNIATIEA 354

  Fly   328 RQ----WNGLLVNLEDSDEEYVRNG---INYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAK 385
            .:    |.|.||.:|.....:::.|   :...|:|.:...:.:.:.|.|....: ..|.:|:.|.
  Fly   355 HEDAHMWFGDLVAIEWWSFLWLKEGFATLFENLAVDLAYPEWDIFQTFHAGSYQ-SALVNDASAN 418

  Fly   386 VKSIATDVKESG-----HQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWE 445
            .:.::..|::..     :..:...|...::.|.:.||.:.:|.:||..:......::|:..:|:|
  Fly   419 ARPMSHFVQKPSEIALLYDSVSYAKAGSVLDMWRHALTNTVFQRGLHNYLVDNQFTAANPSKLFE 483

  Fly   446 EFQRGA-RRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDC 509
            ...:.| ..::::.  .::|.:|.||..|.|.|||||.|:......|:.|| .|....|.:::..
  Fly   484 AIAKAAVEENYEVK--ATVPDMMGSWTNQGGVPLLTVTRNYDNGSFTVKQS-VYTNDKDYTNDKL 545

  Fly   510 WWVPVAYI-VRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLI 573
            |:||:.|. .:|......|......|..:|...|.: :..:||::|..:....||.||:.|.|||
  Fly   546 WYVPINYAESKNPDFRNTEATHYLLNQSEITIYSDL-DQTNWLILNKKSTGYYRVLYDAQNYQLI 609

  Fly   574 SEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQS 638
            :.||.....:|...:|.||::|....:.|||:|:...|.:::||..|.....|......:..|..
  Fly   610 TSALITRPHKIDPRNRAQLINDLYRFATSGRVPHATLLELLTYLPQEDQYSPWSATNTVITLLNR 674

  Fly   639 IMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESP 703
            .:.....:..|:.|:::|:...|                           :..|..::
  Fly   675 YLSGDADYGNFQFYVRELVSLQF---------------------------DKFGVNDN------- 705

  Fly   704 DTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQA 768
                                  ..|....|.|..       :|..|||...::.|||:...:..|
  Fly   706 ----------------------KGDHHLVPFTRN-------VLINLACLAGLENCLTETTAKLTA 741

  Fly   769 AMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQK 833
            .:::  .:.|...::..|.|.|::...:..:..|.:....|.:..||.:|:::|.|:.....::|
  Fly   742 LVEE--GTKIEPNLQSQVYCNGLKQADDKTFDFVFNKLLNSTDQAERRLLISALGCSQNTAQLEK 804

  Fly   834 LLSWALDSKKVPRTMTASLLSAVL-RSPLGYYVGKQFLIDHSKEILRSKDVKLILTPFINAMSTK 897
            .:..:::.:.:......::||.|. |..:|..|..:||                       ....
  Fly   805 FVYSSIEPEGLRDQERITVLSPVYSRGEVGLLVAIEFL-----------------------QKNW 846

  Fly   898 AEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLLKAIRDFTLDDGPKNS 956
            .::..||                    ||...|   |.||.|:: .|..:|::|..|::
  Fly   847 EKYGQLN--------------------SGFGGV---NPLYSDIV-GISAYTVNDKQKDA 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	104/485 (21%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	67/378 (18%)
CG31233	NP_001303538.1	Peptidase_M1	57..443	CDD:279741	88/413 (21%)
		M1_APN_2	65..514	CDD:189008	104/485 (21%)
		ERAP1_C	587..905	CDD:288671	76/407 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940