DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG5849

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_650979.1	Gene:	CG5849 / 42556	FlyBaseID:	FBgn0038897	Length:	968	Species:	Drosophila melanogaster

Alignment Length:	1060	Identity:	227/1060 - (21%)
Similarity:	405/1060 - (38%)	Gaps:	241/1060 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILVLFCTLLSAKLAE--------SFVKPLRYNLTILTRLGSEDEQNQ--FEGIVSIDIEATQPTR 59
            :||....|:|..:.|        :...||.|.|    .:.|:..:.|  |.|..:||:...|.|.
  Fly    10 VLVTLGLLVSGSMGERERSLRLPNATYPLFYQL----HISSDIHKGQLLFSGNATIDVAIRQSTN 70

  Fly    60 VIYLNSLNITISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIEL----PLRSGEIYTLNML 120
            .|.|::.|:| ..|.|.....|.|.:| ...:...:..|:.:.|:..:    ....|:.|.|.:|
  Fly    71 EIVLHAKNLT-DIQITVHRLMAEGSEI-VDDLTHTLHPTAALLIIHPIENYQAFEEGQQYRLEIL 133

  Fly   121 FSGNLDRSQQYGYFAGYYDK--TPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYV 183
            ::..:.......|:..|.|:  ...|:.:||:.||.|...:|||:|:|.|::.::|.:.|...:.
  Fly   134 YTAIMASRPAGLYYMDYRDEENNHTVYVAATQCEPTYGRLIFPCYDEPGFKSNFSIKITHGSSHS 198

  Fly   184 ALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLH---QLEKVYSGPAAAGENIT--VWS 243
            |:||||..|...:.:::   :|:|..:||::|..|.:.:.   .:.:.|.|       ||  :::
  Fly   199 AISNMPVKEVLAHGDLK---TTSFHTTPPISTYLVAFVISDFGSISETYRG-------ITQSIYT 253

  Fly   244 RPHLAEKLAKVPEMTPNLFSKYETLF--AYPLPKGADWGGKVDHVVLPR-YTEMYSGQGIMVYGE 305
            .|...||.....:......:..|..|  :||||       |:|||.|.: |.......|::.|.:
  Fly   254 SPTSKEKGQVALKNAVRTVAALEDYFGVSYPLP-------KLDHVALKKNYGAAMENWGLITYKD 311

  Fly   306 -----DIVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQV-------- 357
                 :|...||.....| .|....:|.||.|.||:.|.....::..|...|.|..:
  Fly   312 VNLLKNISSDGQKRKLDL-ITQNHEIAHQWFGNLVSPEWWTYTWMNEGFATYFSYVITDLIYPND 375

  Fly   358 ----MAMDKEA-----YNT-------THLSKTRLDVLYHDSLAKVKSIATDVKESGHQKLRKKKM 406
                |.|..||     ||:       :|..:...|::.          ..|:       :..|:.
  Fly   376 KMMDMFMTHEADSAYSYNSFFDVHPMSHYVEGEKDIMG----------VFDI-------ISYKRG 423

  Fly   407 CLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWE----EFQRGARRSHQLPTGVSLPTVM 467
            ..:|.|...|...|||::|:..|.::|..|.|:...|::    |.|.....||| |....:..:|
  Fly   424 ACVIKMFHHAFRQKLFVRGISHFLEKYRYSVANELNLFDALHSELQDDEYFSHQ-PWASRIREIM 487

  Fly   468 ESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVR---NLTLPQVE-W 528
            .||......|:|.|.|:.....:|.||...:.|      ::.||:|:.:...   |....||: :
  Fly   488 LSWTHSEWLPILVVTRNYENNTITFTQRSVHMK------DELWWIPINFATTQSPNFEDTQVDMF 546

  Fly   529 LGCQKNSRDILE-LSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQL 592
            :..|......|| |:...:..||:::|........|.||:.||..|:..|:.:.:.|..::|:.|
  Fly   547 MPPQPQYTVSLEDLNIHVSGRDWIMVNKQHTGFYLVRYDTDNLMAIARQLQTNHSVIHPINRLGL 611

  Fly   593 VDDALSLSWSGRLPYN------VTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKL 651
            ..|...|     :.:|      |...::.||..|..||.|......:|.|...:..|:...:|..
  Fly   612 FRDLGPL-----IEHNEIEQVEVVFELLKYLELEEDVLTWNQLQDTIECLTRNLHGTSSQSLFNE 671

  Fly   652 YMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSN 716
            ::::|:.|.|:          |...|..:|                       .||
  Fly   672 FVRRLVGPTFR----------RVYVEQGVN-----------------------LAE--------- 694

  Fly   717 TTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQK---SSSSI 778
                                  |.....|| .:||..::.|||...::..:..:..|   ...|.
  Fly   695 ----------------------DGMFRGIL-EIACSADLPECLEYTRRLAKEHIIDKIYFKDGSD 736

  Fly   779 PEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSI----LLNSLSCTTEYWAMQKLLSWAL 839
            ...|.:.|||.|:|...:..:..:.||..|.:   ..|:    ::.:|.||..:..:...|...:
  Fly   737 YHAIIDSVLCMGVRYLSDQDFQRIIDMMQEID---RASVYYDDIIYALRCTQSHRHLLYYLEGLM 798

  Fly   840 DSKKVPRTMT-------------ASLLSAVLRSPLGYYVGKQF--------LIDHSKEILRSKDV 883
            ........::             ::|.|   |..:..|:.:.:        .::|.|:
  Fly   799 GENSTHMVLSEFEDLMYLLYIYKSNLAS---RPVIWQYIERNYKVLCRAPNFLEHFKQ------- 853

  Fly   884 KLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSST-----LESGL--DRVNWRNNLYFDLL 941
               |..|: ....::.|..|...:..::   |..||::.     ::|.|  .::....|......
  Fly   854 ---LAGFV-PRHQRSHFERLRQTIANHM---MQEGLNTNQTLIEVDSPLVGKKMKITENFQDKFE 911

  Fly   942 KAIRDFTLDDGPKNSSDSDS 961
            :.|..:.|::.|:.:|.||:
  Fly   912 QQIHKWLLNELPQATSRSDA 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	122/500 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	72/418 (17%)
CG5849	NP_650979.1	Peptidase_M1	30..423	CDD:279741	102/433 (24%)
		M1_APN_2	38..497	CDD:189008	122/500 (24%)
		ERAP1_C	570..>841	CDD:288671	61/346 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850