DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG8773

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster

Alignment Length:	916	Identity:	209/916 - (22%)
Similarity:	367/916 - (40%)	Gaps:	192/916 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            :||..|:|.:...:    |..:|.|..:|.|...:.|..|.|:|||:.||.        .|....
  Fly   127 LKPTHYDLYLFPNI----ETGEFSGQETITITVEEATDQIVLHSLNLNISS--------VSIMNT 179

  Fly    87 GALQIKRIIKKTSLIK--IVIEL--PLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY---DKTPRV 144
            |:..::.:......::  ::.:|  ||..|....|::.|.|:: .::..|.::..|   |:| |.
  Fly   180 GSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSM-ANKIVGLYSSSYVKEDET-RK 242

  Fly   145 FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVH--DRKYVALSNM---PPVEEKPYKEIENYVS 204
            :.:.::.||.||...|||||:|..:..:.|||||  ...|.|||||   ..|.:..::|:
  Fly   243 WIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQEV----- 302

  Fly   205 TTFMGSPPLATQQVMWTLHQL--EKVYSGPAAAGE--NITVWSRPHLAEKLAKVPEMTPNLFSKY 265
             ||..|.|::|....:.:...  ::|.......||  :::|::.|...:|:.....:...:...|
  Fly   303 -TFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYY 366

  Fly   266 ETLF--AYPLPKGADWGGKVDHVVLPRYTEMYSGQ----GIMVYGE-----DIVDSGQNGLESLQ 319
            ...|  |||||       |:|...:|   :..||.    |::.|.|     |...|.....:.:.
  Fly   367 IDYFQIAYPLP-------KLDMAAIP---DFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIA 421

  Fly   320 ETLAELVARQWNGLLVNLEDSDEEYVRNGIN---YYLSVQVM-----AMDKEAYNTTHLSKTRLD 376
            ..:|...|..|.|.||.:...::.::..|..   .||.|..:     ..|:...:|.| |...||
  Fly   422 SVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLH-SVLTLD 485

  Fly   377 -----------VLYHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFF 430
                       |...|.:.::....|..|.|.           |:.||:..||:..|.:.:..:.
  Fly   486 GTLGSHPIIQTVENPDQITEIFDTITYSKGSS-----------LVRMLEDFLGETTFRQAVTNYL 539

  Fly   431 KRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQS 495
            ..|..|:|.:...:.|..:       |..|.::..:|.:|..|.|.|::|:::      |:.|:.
  Fly   540 NEYKYSTAETGNFFTEIDK-------LELGYNVTEIMLTWTVQMGLPVVTIEK------VSDTEY 591

  Fly   496 RYYQKYLDNSSNDC------------WWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPE 548
            :..||...::.||.            |.:|:.|...:.::.|..|.     ..|..|:: :..|.
  Fly   592 KLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWF-----YHDQSEIT-VTVPA 650

  Fly   549 --DWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTL 611
              :|:..|.|.....||.||:.....:::.|....:....:.|..|::||.:|:.|.:|||....
  Fly   651 AVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAF 715

  Fly   612 NVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGS 676
            .:..||..||..:.|..|...|..|:..:..|:.:..:|.|...||||.: |.|      ..|..
  Fly   716 ELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIY-TAL------TWTVG 773

  Fly   677 EIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLS 741
            |..::.:..||                                                     :
  Fly   774 EDHLDNRLRVT-----------------------------------------------------A 785

  Fly   742 LSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRN-GLEVHWIMVRDM 805
            |||     ||...::.|||:|.::|.|.: .|.......::||.|...||:: |.:..|..|.::
  Fly   786 LSA-----ACSLGLESCLTEAGEQFNAWL-AKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWEL 844

  Fly   806 FFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFL 870
            |....:..|:|.|:..||.....|.:|:.:..|.:.:.|......:.|:.:..:|    ||:..:
  Fly   845 FVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANP----VGESLV 905

  Fly   871 IDHSKE 876
            .|:.:|
  Fly   906 WDYVRE 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	117/497 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	73/327 (22%)
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	101/418 (24%)
		M1_APN_2	130..579	CDD:189008	117/497 (24%)
		ERAP1_C	655..969	CDD:288671	73/327 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850